dc.contributor |
Landbúnaðarháskóli Íslands |
dc.contributor |
Agricultural University of Iceland |
dc.contributor.author |
Xu, Song-Song |
dc.contributor.author |
Gao, Lei |
dc.contributor.author |
Xie, Xing-Long |
dc.contributor.author |
Ren, Yan-Ling |
dc.contributor.author |
Shen, Zhi-Qiang |
dc.contributor.author |
Wang, Feng |
dc.contributor.author |
Shen, Min |
dc.contributor.author |
Eythorsdottir, Emma |
dc.contributor.author |
Hallsson, Jon |
dc.contributor.author |
Kiseleva, Tatyana |
dc.contributor.author |
Kantanen, Juha |
dc.contributor.author |
Li, Meng-Hua |
dc.date.accessioned |
2019-09-24T11:13:48Z |
dc.date.available |
2019-09-24T11:13:48Z |
dc.date.issued |
2018-04-10 |
dc.identifier.citation |
Xu, S. S., Gao, L., Xie, X. L., Ren, Y. L., Shen, Z. Q., Wang, F., ... & Kantanen, J. (2018). Genome-wide association analyses highlight the potential for different genetic mechanisms for litter size among sheep breeds. Frontiers in genetics, 9, 118. |
dc.identifier.issn |
1664-8021 |
dc.identifier.uri |
https://hdl.handle.net/20.500.11815/1260 |
dc.description |
Author Contributions: M-HL conceived and designed the project. FW, Z-QS, Y-LR, MS, EE, JH, JK, and TK collected the samples. X-LX extracted the DNA. JK provided help in Beadchip genotyping. S-SX and LG analyzed the data. S-SX wrote the paper with contributions from M-HL. All authors reviewed and approved the final manuscript. |
dc.description.abstract |
Reproduction is an important trait in sheep breeding as well as in other livestock. However, despite its importance the genetic mechanisms of litter size in domestic sheep (Ovis aries) are still poorly understood. To explore genetic mechanisms underlying the variation in litter size, we conducted multiple independent genome-wide association studies in five sheep breeds of high prolificacy (Wadi, Hu, Icelandic, Finnsheep, and Romanov) and one low prolificacy (Texel) using the Ovine Infinium HD BeadChip, respectively. We identified different sets of candidate genes associated with litter size in different breeds: BMPR1B, FBN1, and MMP2 in Wadi; GRIA2, SMAD1, and CTNNB1 in Hu; NCOA1 in Icelandic; INHBB, NF1, FLT1, PTGS2, and PLCB3 in Finnsheep; ESR2 in Romanov and ESR1, GHR, ETS1, MMP15, FLI1, and SPP1 in Texel. Further annotation of genes and bioinformatics analyses revealed that different biological pathways could be involved in the variation in litter size of females: hormone secretion (FSH and LH) in Wadi and Hu, placenta and embryonic lethality in Icelandic, folliculogenesis and LH signaling in Finnsheep, ovulation and preovulatory follicle maturation in Romanov, and estrogen and follicular growth in Texel. Taken together, our results provide new insights into the genetic mechanisms underlying the prolificacy trait in sheep and other mammals, suggesting targets for selection where the aim is to increase prolificacy in breeding projects. |
dc.description.sponsorship |
This work was supported by grants from the National Natural Science Foundation of China (Grant Nos. 91731309 and 31661143014), the Taishan Scholars Program of Shandong Province (No. ts201511085), the National Transgenic Breeding Project of China (2014ZX0800952B), the Academy of Finland (Grant No. 250633), and the Climate Genomics for Farm Animal Adaptation (ClimGen) Project. |
dc.format.extent |
118 |
dc.language.iso |
en |
dc.publisher |
Frontiers Media SA |
dc.relation.ispartofseries |
Frontiers in Genetics;9 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Sheep |
dc.subject |
Genome-wide association studies |
dc.subject |
Prolificacy |
dc.subject |
Sauðfé |
dc.subject |
Erfðarannsóknir |
dc.title |
Genome-Wide Association Analyses Highlight the Potential for Different Genetic Mechanisms for Litter Size Among Sheep Breeds |
dc.type |
info:eu-repo/semantics/article |
dcterms.license |
Frontiers is fully compliant with open access mandates, by publishing its articles under the Creative Commons Attribution licence (CC-BY). Funder mandates such as those by the Wellcome Trust (UK), National Institutes of Health (USA) and the Australian Research Council (Australia) are fully compatible with publishing in Frontiers. Authors retain copyright of their work and can deposit their publication in any repository. The work can be freely shared and adapted provided that appropriate credit is given and any changes specified. |
dc.description.version |
Peer Reviewed |
dc.identifier.journal |
Frontiers in Genetics |
dc.identifier.doi |
10.3389/fgene.2018.00118 |
dc.relation.url |
http://journal.frontiersin.org/article/10.3389/fgene.2018.00118/full |
dc.contributor.department |
Auðlinda- og umhverfisdeild (LBHÍ) |
dc.contributor.department |
Faculty of Natural Resources and Environmental Sciences (AUI) |