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Fletta eftir efnisorði "Sýklódextrín"
Atriði 1-11 af 11
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(2021-05-18)The purpose of this study was to evaluate the ocular pharmacokinetics, bio-distribution and local tolerability of γ-cyclodextrin (γCD) based irbesartan 1.5% eye drops and candesartan 0.15% eye drops after single and multiple topical administration in ... -
(MDPI AG, 2020-06-20)Ascorbic acid (AA) is a general antioxidant used in aqueous pharmaceutical formulations. However, in aqueous solutions, AA is unstable and easily oxidized when exposed to air, light and/or heat. Cyclodextrins are well known for their ability to form ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2020-11)Background: Age-related macular degeneration (AMD) causes vision loss in elderly people due to neovascularization. The first line treatments are intravitreal injections which can induce severe pain. Oral administration still produces side effects. ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2020-10-26)Ocular drug delivery is very challenging due to the anatomical and physiological barriers of the eye. Poor aqueous solubility of many drugs and short retention time at ocular surfaces makes the formulation of topical dosage forms even more challenging. ...
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(MDPI AG, 2019-05-15)Natamycin is the only drug approved for fungal keratitis treatment, but its low water solubility and low ocular penetration limit its efficacy. The purpose of this study was to overcome these limitations by encapsulating the drug in single or mixed ...
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(MBPI, 2021-03)Cyclodextrins (CDs) have been widely used as pharmaceutical excipients for formulation purposes for different delivery systems. Recent studies have shown that CDs are able to form complexes with a variety of biomolecules, such as cholesterol. This has ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2022-09)gamma-Cyclodextrin (gCD) has been recently used as pharmaceutical excipient in topical formulation for ocular delivery. The high corticosteroid concentration in various ocular tissues has been reported after topical application of aqueous eye drops, ...
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(MDPI AG, 2020-04-09)The aim of this study was to design and evaluate novel cyclodextrin (CD)-based aggregate formulations to efficiently deliver nepafenac topically to the eye structure, to treat inflammation and increase nepafenac levels in the posterior segment, thus ...
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(MDPI AG, 2019-01-11)The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2022-11-01)Fyrir marga lyfjaflokka þykir staðbundin lyfjagjöf í augndropaformi ákjósanlegasta leiðin vegna einfaldleika við lyfjagjöf. Eru augndropar algengasta aðferðin til að meðhöndla augnsjúkdóma í fremri hluta augans. Staðbundin lyfjagjöf í augndropaformi ...
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(Elsevier, 2020)Tacrolimus is a macrolide lactone and potent immunosuppressant. It is highly lipophilic and has very limited aqueous solubility. Tacrolimus is highly susceptible to hydrolysis which results in very limited stability in aqueous solutions. Besides this, ...
Atriði 1-11 af 11