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Fletta eftir efnisorði "Proteomics"

Fletta eftir efnisorði "Proteomics"

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    Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer 
    Karvelsson, Sigurður Trausti; Wang, Qiong; Hilmarsdóttir, Bylgja; Sigurðsson, Arnar; Moestue, Siver Andreas; Mælandsmo, Gunhild Mari; Halldórsson, Skarphédinn; Guðmundsson, Steinn; Rolfsson, Óttar (2021-09-17)
    Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic phenotypes ...
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    The complexity of kidney disease and diagnosing it - cystatin C, selective glomerular hypofiltration syndromes and proteome regulation 
    Malmgren, Linnea; Öberg, Carl; den Bakker, Emil; Leion, Felicia; Siódmiak, Joanna; Åkesson, Anna; Lindström, Veronica; Herou, Erik; Dardashti, Alain; Xhakollari, Liana; Grubb, Gabriel; Strevens, Helena; Abrahamson, Magnus; Helmersson-Karlqvist, Johanna; Magnusson, Martin; Björk, Jonas; Nyman, Ulf; Ärnlöv, Johan; Ridefelt, Peter; Åkerfeldt, Torbjörn; Hansson, Magnus; Sjöström, Anna; Mårtensson, Johan; Itoh, Yoshihisa; Grubb, David; Tenstad, Olav; Hansson, Lars-Olov; Ólafsson, Ísleifur; Campos, Araceli Jarquin; Risch, Martin; Risch, Lorenz; Larsson, Anders; Nordin, Gunnar; Pottel, Hans; Christensson, Anders; Bjursten, Henrik; Bökenkamp, Arend; Grubb, Anders (2023-03)
    Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)-markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new ...
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    The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland : A Large-Scale Proteomics Scan in Iceland 
    Styrkarsdottir, Unnur; Lund, S.H.; Saevarsdottir, S.; Magnusson, M.I.; Gunnarsdottir, K.; Norddahl, Gudmundur L.; Frigge, Michael L.; Ivarsdottir, E.V.; Bjornsdottir, Gyda; Holm, Hilma; Thorgeirsson, Guðmundur; Rafnar, T.; Jonsdottir, I.; Ingvarsson, T.; Jonsson, H.; Sulem, P.; Thorsteinsdottir, U.; Gudbjartsson, Daniel Fannar; Stefansson, K.; Thorgeirsson, Gudmundur; Ingvarsson, Þorvaldur (2021-11)
    Objective: Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods: Using ...
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    Exploratory Investigation of the Plasma Proteome Associated with the Endotheliopathy of Trauma 
    Krocker, Joseph D.; Lee, Kyung Hyun; Henriksen, Hanne H.; Wang, Yao Wei Willa; Schoof, Erwin M.; Karvelsson, Sigurdur T.; Rolfsson, Óttar; Johansson, P. I.; Pedroza, Claudia; Wade, Charles E. (2022-06-01)
    Background: The endotheliopathy of trauma (EoT) is associated with increased mortality following injury. Herein, we describe the plasma proteome related to EoT in order to provide insight into the role of the endothelium within the systemic response ...
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    Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset 
    Sævarsdóttir, Sædís; Stefansdottir, Lilja; Sulem, P.; Thorleifsson, G.; Ferkingstad, E.; Rutsdottir, G.; Glintborg, B.; Westerlind, H.; Gröndal, Gerður María; Loft, I.C.; Sorensen, S.B.; Lie, B.A.; Brink, M.; Arlestig, L.; Arnthorsson, A.O.; Baecklund, E.; Banasik, K.; Bank, S.; Bjorkman, L.I.; Ellingsen, T.; Erikstrup, C.; Frei, O.; Gjertsson, I.; Gudbjartsson, D.F.; Gudjonsson, S.A.; Halldorsson, G.H.; Hendricks, O.; Hillert, J.; Hogdall, E.; Jacobsen, Sø; Jensen, D.V.; Jonsson, Helgi; Kastbom, A.; Kockum, I.; Kristensen, S.; Kristjansdottir, Helga; Larsen, M.H.; Linauskas, A.; Hauge, E.-M.; Loft, A.G.; Lúðvíksson, Björn Rúnar; Lund, S.H.; Markusson, Þorsteinn; Masson, G.; Melsted, P.; Moore, K.H.S.; Munk, H.; Nielsen, K.R.; Norddahl, G.L.; Oddsson, A.; Olafsdottir, T.A.; Olason, P.I.; Olsson, T.; Ostrowski, S.R.; Hørslev-Petersen, K.; Rognvaldsson, S.; Sanner, H.; Silberberg, G.N.; Stefansson, H.; Sørensen, E.; Sørensen, I.J.; Turesson, C.; Bergman, T.; Alfredsson, L.; Kvien, T.K.; Brunak, Sø; Steinsson, K.; Andersen, V.; Andreassen, O.A.; Rantapää-Dahlqvist, S.; Hetland, M.L.; Klareskog, L.; Askling, J.; Padyukov, L.; Pedersen, O.B.V.; Thorsteinsdottir, U.; Jonsdottir, I.; Stefánsson, Kári (2022-04-25)
    Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and ∼1 million ...
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    Multiomics study of nonalcoholic fatty liver disease 
    DBDS Genomic Consortium (2022-10-24)
    Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and integrated the findings with expression and proteomic data. For NAFL, we ...
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    Predicting the probability of death using proteomics 
    Eiriksdottir, Thjodbjorg; Ardal, Steinthor; Jonsson, Benedikt A.; Lund, Sigrun H.; Ivarsdottir, Erna V.; Norland, Kristjan; Ferkingstad, Egil; Stefansson, Hreinn; Jónsdóttir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Þorgeirsson, Guðmundur; Gudbjartsson, Daniel F.; Sulem, Patrick; Thorsteinsdottir, Unnur; Stefansson, Kari; Úlfarsson, Magnús Örn (2021-06-18)
    Predicting all-cause mortality risk is challenging and requires extensive medical data. Recently, large-scale proteomics datasets have proven useful for predicting health-related outcomes. Here, we use measurements of levels of 4,684 plasma proteins ...
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    S-nitrosylation in Neuropathic pain and Autophagy 
    Scheving, Reynir (Johann Wolfgang Goethe University, Frankfurt am Main, 2013)
    Neuropathic pain is a maladaptive form of chronic pain caused by a primary injury or lesions in the central or peripheral nervous systems. Recently nitric oxide (NO) has emerged as important pro-nociceptive signaling molecule in pain signaling and ...
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    Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans 
    Ravindra, Kodihalli C; Vaidya, Vishal S; Wang, Zhenyu; Federspiel, Joel D; Virgen-Slane, Richard; Everley, Robert A; Grove, Jane I; Stephens, Camilla; Ocana, Mireia F; Robles-Díaz, Mercedes; Isabel Lucena, M; Andrade, Raul J; Atallah, Edmond; Gerbes, Alexander L; Weber, Sabine; Cortez-Pinto, Helena; Fowell, Andrew J; Hussaini, Hyder; Björnsson, Einar Stefán; Patel, Janisha; Stirnimann, Guido; Verma, Sumita; Elsharkawy, Ahmed M; Griffiths, William J H; Hyde, Craig; Dear, James W; Aithal, Guruprasad P; Ramaiah, Shashi K (2023-03-03)
    Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of ...
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    UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines 
    Wang, Qiong; Karvelsson, Sigurdur Trausti; Johannsson, Freyr; Vilhjalmsson, Arnar Ingi; Hagen, Lars; de Miranda Fonseca, Davi; Sharma, Animesh; Slupphaug, Geir; Rolfsson, Ottar (2022-05)
    Metabolic rewiring is one of the indispensable drivers of epithelial–mesenchymal transition (EMT) involved in breast cancer metastasis. In this study, we explored the metabolic changes during spontaneous EMT in three separately established breast EMT ...