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Browsing by Subject "Polymorphism, Single Nucleotide/genetics"

Browsing by Subject "Polymorphism, Single Nucleotide/genetics"

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    Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis : a genome-wide study 
    Regeneron Genetics Center (2023-06-01)
    AIMS: Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype ...
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    Mapping genomic loci implicates genes and synaptic biology in schizophrenia 
    Indonesia Schizophrenia Consortium; Sigurðsson, Engilbert (2022-04-08)
    Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant ...
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    The sequences of 150,119 genomes in the UK Biobank 
    DBDS Genetic Consortium (2022-07-20)
    Detailed knowledge of how diversity in the sequence of the human genome affects phenotypic diversity depends on a comprehensive and reliable characterization of both sequences and phenotypic variation. Over the past decade, insights into this relationship ...