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Fletta eftir efnisorði "Metabolomics"

Fletta eftir efnisorði "Metabolomics"

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    Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort 
    Hernandes, Vinicius Verri; Dordevic, Nikola; Hantikainen, Essi Marjatta; Sigurðsson, Baldur Bragi; Smárason, Sigurður Vidir; Garcia-Larsen, Vanessa; Gögele, Martin; Caprioli, Giulia; Bozzolan, Ilaria; Pramstaller, Peter P.; Rainer, Johannes (2022-02-24)
    Metabolomics in human serum samples provide a snapshot of the current metabolic state of an individuum. Metabolite concentrations are influenced by both genetic and environmental factors. Concentrations of certain metabolites can further depend on age, ...
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    Circulating N-formylmethionine and metabolic shift in critical illness : a multicohort metabolomics study 
    Sigurðsson, Martin Ingi; Kobayashi, Hirotada; Amrein, Karin; Nakahira, Kiichi; Rogers, Angela J.; Pinilla-Vera, Mayra; Baron, Rebecca M.; Fredenburgh, Laura E.; Lasky-Su, Jessica A.; Christopher, Kenneth B. (2022-10-19)
    BACKGROUND: Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N-formylmethionine. We hypothesized that in critically ill adults, the response to N-formylmethionine is associated ...
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    Coupling MALDI-TOF mass spectrometry protein and specialized metabolite analyses to rapidly discriminate bacterial function 
    Clark, Chase M.; Costa, Maria Sofia; Sanchez, Laura M.; Murphy, Brian T. (Proceedings of the National Academy of Sciences, 2018-04-23)
    For decades, researchers have lacked the ability to rapidly correlate microbial identity with bacterial metabolism. Since specialized metabolites are critical to bacterial function and survival in the environment, we designed a data acquisition and ...
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    Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine 
    Sigmarsdóttir, Þóra; McGarrity, Sarah; Rolfsson, Óttar; Yurkovich, James T.; Sigurjónsson, Ólafur E. (Frontiers Media SA, 2020-03-31)
    Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct ...
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    Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics 
    Bordbar, Aarash; Yurkovich, James T.; Paglia, Giuseppe; Rolfsson, Óttar; Sigurjónsson, Ólafur E.; Palsson, Bernhard O. (Springer Nature, 2017-04-07)
    The increasing availability of metabolomics data necessitates novel methods for deeper data analysis and interpretation. We present a flux balance analysis method that allows for the computation of dynamic intracellular metabolic changes at the cellular ...
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    Endothelial Cell Phenotypes Demonstrate Different Metabolic Patterns and Predict Mortality in Trauma Patients 
    Henriksen, Hanne H.; Marín de Mas, Igor; Nielsen, Lars K.; Krocker, Joseph; Stensballe, Jakob; Karvelsson, Sigurður T.; Secher, Niels H.; Rolfsson, Óttar; Wade, Charles E.; Johansson, Pär I. (2023-01-23)
    In trauma patients, shock-induced endotheliopathy (SHINE) is associated with a poor prognosis. We have previously identified four metabolic phenotypes in a small cohort of trauma patients (N = 20) and displayed the intracellular metabolic profile of ...
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    Metabolic Profiling as a Screening Tool for Cytotoxic Compounds: Identification of 3-Alkyl Pyridine Alkaloids from Sponges Collected at a Shallow Water Hydrothermal Vent Site North of Iceland 
    Einarsdóttir, Eydís; Magnúsdóttir, Manuela; Astarita, Giuseppe; Köck, Matthias; Ögmundsdóttir, Helga M.; Þorsteinsdóttir, Margrét; Rapp, Hans; Omarsdottir, Sesselja; Paglia, Giuseppe (MDPI AG, 2017-02-22)
    Twenty-eight sponge specimens were collected at a shallow water hydrothermal vent site north of Iceland. Extracts were prepared and tested in vitro for cytotoxic activity, and eight of them were shown to be cytotoxic. A mass spectrometry (MS)-based ...
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    Metabolic Response in Endothelial Cells to Catecholamine Stimulation Associated with Increased Vascular Permeability 
    Lomana, Adrián López García de; Vilhjálmsson, Arnar Ingi; McGarrity, Sarah; Sigurðardóttir, Rósa S.; Anuforo, Osk U.U.; Viktorsdóttir, Alexía Rós; Kotronoulas, Aris; Bergmann, Andreas; Franzson, Leifur; Halldórsson, Haraldur; Henriksen, Hanne H.; Wade, Charles E.; Johansson, Pär Ingemar; Rolfsson, Óttar (2022-03-15)
    Disruption to endothelial cell homeostasis results in an extensive variety of human pathologies that are particularly relevant to major trauma. Circulating catecholamines, such as adrenaline and noradrenaline, activate endothelial adrenergic receptors ...
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    Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction 
    Tribble, James R.; Otmani, Amin; Sun, Shanshan; Ellis, Sevannah A.; Cimaglia, Gloria; Vohra, Rupali; Jöe, Melissa; Lardner, Emma; Venkataraman, Abinaya P.; Domínguez-Vicent, Alberto; Kokkali, Eirini; Rho, Seungsoo; Jóhannesson, Gauti; Burgess, Robert W.; Fuerst, Peter G.; Brautaset, Rune; Kolko, Miriam; Morgan, James E.; Crowston, Jonathan G.; Votruba, Marcela; Williams, Pete A. (2021-07)
    Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. We assess the effects of nicotinamide (a precursor to ...
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    The quantitative metabolome is shaped by abiotic constraints 
    Akbari, Amir; Yurkovich, James T.; Zielinski, Daniel C.; Pálsson, Bernhard Örn (2021-05-26)
    Living systems formed and evolved under constraints that govern their interactions with the inorganic world. These interactions are definable using basic physico-chemical principles. Here, we formulate a comprehensive set of ten governing abiotic ...
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    Visualizing metabolic network dynamics through time-series metabolomic data 
    Buchweitz, Lea F.; Yurkovich, James T.; Blessing, Christoph; Kohler, Veronika; Schwarzkopf, Fabian; King, Zachary A.; Yang, Laurence; Jóhannsson, Freyr; Sigurjónsson, Ólafur E.; Rolfsson, Óttar; Heinrich, Julian; Dräger, Andreas (Springer Science and Business Media LLC, 2020-04-03)
    Background: New technologies have given rise to an abundance of-omics data, particularly metabolomic data. The scale of these data introduces new challenges for the interpretation and extraction of knowledge, requiring the development of innovative ...