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Fletta eftir efnisorði "Metabolism"

Fletta eftir efnisorði "Metabolism"

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    Characterization of ATG7 protein coding isoforms 
    Ostacolo, Kevin (University of Iceland, School of Health Sciences, Faculty of Medicine, 2023-11-16)
    ATG7, an essential protein for cellular homeostasis, plays a pivotal role in regulating autophagy. The autophagy process ensures the degradation and recycling of cellular components for proper cell function. ATG7 facilitates the lipidation of ATG8 ...
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    Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine 
    Sigmarsdóttir, Þóra; McGarrity, Sarah; Rolfsson, Óttar; Yurkovich, James T.; Sigurjónsson, Ólafur E. (Frontiers Media SA, 2020-03-31)
    Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct ...
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    GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer 
    Zhou, Wei; Brumpton, Ben; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Josh; Zawistowski, Matthew; Nielsen, Jonas B.; Chaker, Layal; Medici, Marco; Teumer, Alexander; Naitza, Silvia; Sanna, Serena; Schultheiss, Ulla T.; Cappola, Anne; Karjalainen, Juha; Kurki, Mitja; Oneka, Morgan; Taylor, Peter; Fritsche, Lars G.; Graham, Sarah E.; Wolford, Brooke N.; Overton, William; Rasheed, Humaira; Haug, Eirin B.; Gabrielsen, Maiken E.; Skogholt, Anne Heidi; Surakka, Ida; Davey Smith, George; Pandit, Anita; Roychowdhury, Tanmoy; Hornsby, Whitney E.; Jonasson, Jon G.; Senter, Leigha; Liyanarachchi, Sandya; Ringel, Matthew D.; Xu, Li; Kiemeney, Lambertus A.; He, Huiling; Netea-Maier, Romana T.; Mayordomo, Jose I.; Plantinga, Theo S.; Hrafnkelsson, Jon; Hjartarson, Hannes; Sturgis, Erich M.; Palotie, Aarno; Daly, Mark; Citterio, Cintia E.; Arvan, Peter; Brummett, Chad M.; Boehnke, Michael; de la Chapelle, Albert; Stefansson, Kari; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav (Springer Science and Business Media LLC, 2020-08-07)
    Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to 119,715 individuals and identify ...
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    Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition 
    Halldorsson, Skarphedinn; Rohatgi, Neha; Magnúsdóttir, Manuela; Choudhary, Kumari Sonal; Gudjonsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdóttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild M.; Guðmundsson, Steinn; Rolfsson, Óttar (Elsevier BV, 2017-06)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
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    Modelling metabolomic changes in human bone marrow derived mesenchymal stem cells during oesteogenic differentiation via genome scale metabolic models to further their use in regenerative medicine 
    Sigmarsdóttir, Thora (2021-09-10)
    Á undanförnum árum hafa sviðin endurnýjunar og tilfærslu lækningar vakið sífellt meiri áhuga vegna möguleikanna sem í þeim felast er varða nýjungar í læknavísindum. Innan þeirra má finna ýmis tól sem talin eru vera lykilatriði þegar kemur að því að ...
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    Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction 
    Tribble, James R.; Otmani, Amin; Sun, Shanshan; Ellis, Sevannah A.; Cimaglia, Gloria; Vohra, Rupali; Jöe, Melissa; Lardner, Emma; Venkataraman, Abinaya P.; Domínguez-Vicent, Alberto; Kokkali, Eirini; Rho, Seungsoo; Jóhannesson, Gauti; Burgess, Robert W.; Fuerst, Peter G.; Brautaset, Rune; Kolko, Miriam; Morgan, James E.; Crowston, Jonathan G.; Votruba, Marcela; Williams, Pete A. (2021-07)
    Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. We assess the effects of nicotinamide (a precursor to ...
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    Responses of Synechocystis sp. PCC 6803 to heterologous biosynthetic pathways 
    Vavitsas, Konstantinos; Rue, Emil Østergaard; Stefánsdóttir, Lára Kristín; Gnanasekaran, Thiyagarajan; Blennow, Andreas; Crocoll, Christoph; Guðmundsson, Steinn; Jensen, Poul Erik (Springer Nature, 2017-08-15)
    Background There are an increasing number of studies regarding genetic manipulation of cyanobacteria to produce commercially interesting compounds. The majority of these works study the expression and optimization of a selected heterologous pathway, ...
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    Systems biology as an emerging paradigm in transfusion medicine 
    Yurkovich, James; Bordbar, Aarash; Sigurjonsson, Olafur; Palsson, Bernhard O. (Springer Nature, 2018-03-07)
    Blood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of transfusion medicine has started to benefit from the “omic” data revolution and corresponding ...
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    Systems biology of human metabolism - Defining the epithelial to mesenchymal transition and the activity of human gluconokinase 
    Rohatgi, Neha (University of Iceland, School of Health Sciences, Faculty of Medicine, 2016-12)
    Studying human metabolism is crucial for the understanding of diseases and improvement of therapy as metabolic alterations are central to a number of human diseases. A variety of experimental disciplines, such as biochemistry, biophysics and systems ...
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    Visualizing metabolic network dynamics through time-series metabolomic data 
    Buchweitz, Lea F.; Yurkovich, James T.; Blessing, Christoph; Kohler, Veronika; Schwarzkopf, Fabian; King, Zachary A.; Yang, Laurence; Jóhannsson, Freyr; Sigurjónsson, Ólafur E.; Rolfsson, Óttar; Heinrich, Julian; Dräger, Andreas (Springer Science and Business Media LLC, 2020-04-03)
    Background: New technologies have given rise to an abundance of-omics data, particularly metabolomic data. The scale of these data introduces new challenges for the interpretation and extraction of knowledge, requiring the development of innovative ...