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Fletta eftir efnisorði "Mergæxli"
Atriði 1-12 af 12
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(2021-03-26)Multiple myeloma (MM) is characterized by extensive immunoglobulin production leading to an excessive load on protein homeostasis in tumor cells. Aminopeptidases contribute to proteolysis by catalyzing the hydrolysis of amino acids from proteins or ... -
(Public Library of Science (PLoS), 2018-11-01)The etiology of monoclonal gammopathy of undetermined significance (MGUS), the precursor state of multiple myeloma (MM), is mostly unknown and no studies have been conducted on the effect of diet on MGUS or progression from MGUS to MM. We aimed to ...
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(2020-04-01)Multiple myeloma causes lytic bone lesions and fractures. The impact of fractures on multiple myeloma (MM) survival is unclear. The aim of this study was to evaluate the effect of fractures on survival in MM using data from MM patients diagnosed in ...
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(2021-05-17)Monoclonal gammopathy of undetermined significance (MGUS) precedes multiple myeloma (MM). Population-based screening for MGUS could identify candidates for early treatment in MM. Here we describe the Iceland Screens, Treats, or Prevents Multiple Myeloma ...
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(Springer Science and Business Media LLC, 2018-09-13)Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, ...
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(2021-02-01)Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect and isotype M-proteins. Increasing ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-04)Transcriptional regulatory mechanisms drive the maturation of B cells to plasma cells, with a dramatic transcriptional rewiring taking place during the transition. This rewiring is dependent on a number of factors, including the transcription factor B ...
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(2021-12-01)Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2023-10-10)Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic disorder caused by the accumulation of monoclonal immunoglobulin secreting cells in the bone marrow. The main clinical implication of MGUS is that it’s the precursor of multiple ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-02)Background and aim: Multiple myeloma is a malignant chronic B-cell disorder characterized by a monoclonal proliferation of plasma cells in the bone marrow. Almost all multiple myeloma cases are preceded by the premalignant state, monoclonal gammopathy ...
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(Ferrata Storti Foundation (Haematologica), 2017-12-07)Epidemiology and outcome of myeloma are mainly reported from large university centers and collaborative groups, and do not represent ‘real-world’ patients. The Swedish Myeloma Registry is a prospective population-based registry documenting characteristics, ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2021-05-21)Inngangur: Með tilkomu áhrifaríkari lyfja í meðhöndlun sjúklinga með mergæxli síðastliðna áratugi hefur lifun þeirra stóraukist. Þessi aukna lifun hefur leitt til aukinnar áherslu rannsakennda á langtíma afleiðingum í formi þróun annarra krabbameina. ...
Atriði 1-12 af 12