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Browsing by Subject "Lyfjagjöf"

Browsing by Subject "Lyfjagjöf"

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  • Cesta, Carolyn E; Cohen, Jacqueline M; Pazzagli, Laura; Bateman, Brian T; Bröms, Gabriella; Einarsdottir, Kristjana; Furu, Kari; Havard, Alys; Heino, Anna; Hernandez-Diaz, Sonia; Huybrechts, Krista F; Karlstad, Øystein; Kieler, Helle; Li, Jiong; Leinonen, Maarit K; Gulseth, Hanne L; Tran, Duong; Yu, Yongfu; Zoega, Helga; Odsbu, Ingvild (BMJ, 2019-11-01)
    Objective Diabetes in pregnancy and consequently the need for treatment with antidiabetic medication (ADM) has become increasingly prevalent. The prevalence and patterns of use of ADM in pregnancy from 2006 onward in seven different countries was ...
  • Udumyan, Ruzan; Montgomery, Scott; Duberg, Ann-Sofi; Fang, Fang; Valdimarsdottir, Unnur; Ekbom, Anders; Smedby, Karin E.; Fall, Katja (Informa UK Limited, 2020-05-03)
    Background: β-adrenergic signaling has been implicated in the pathology of hepatocellular carcinoma (HCC), but the evidence from clinical studies is limited. In this national population-based cohort study, we investigated the possible association of ...
  • Lorenzo Veiga, Blanca (University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2020-10-26)
    Ocular drug delivery is very challenging due to the anatomical and physiological barriers of the eye. Poor aqueous solubility of many drugs and short retention time at ocular surfaces makes the formulation of topical dosage forms even more challenging. ...
  • Michelsen, Brigitte; Lindström, Ulf; Codreanu, Catalin; Ciurea, Adrian; Zavada, Jakub; Loft, Anne Gitte; Pombo-Suarez, Manuel; Onen, Fatos; Kvien, Tore K; Rotar, Ziga; Santos, Maria Jose; Iannone, Florenzo; Hokkanen, Anna-Mari; Gudbjornsson, Bjorn; Askling, Johan; Ionescu, Ruxandra; Nissen, Michael J; Pavelka, Karel; Sanchez-Piedra, Carlos; Akar, Servet; Sexton, Joseph; Tomsic, Matija; Santos, Helena; Sebastiani, Marco; Österlund, Jenny; Geirsson, Arni Jon; Macfarlane, Gary; van der Horst-Bruinsma, Irene; Georgiadis, Stylianos; Brahe, Cecilie Heegaard; Ørnbjerg, Lykke Midtbøll; Hetland, Merete Lund; Østergaard, Mikkel (BMJ, 2020-09-01)
    OBJECTIVES: To explore 6-month and 12-month secukinumab effectiveness in patients with axial spondyloarthritis (axSpA) overall, as well as across (1) number of previous biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs), (2) ...
  • Kharlamova, Nastya; Hermanrud, Christina; Dunn, Nicky; Ryner, Malin; Hambardzumyan, Karen; Vivar Pomiano, Nancy; Marits, Per; Gjertsson, Inger; Saevarsdottir, Saedis; Pullerits, Rille; Fogdell-Hahn, Anna (Frontiers Media SA, 2020-07-21)
    A subgroup of patients treated with infliximab lose response to the treatment and one reason for this is the development of anti-drug antibodies (ADA). If used optimally, measuring drug and ADA level could lead to a more personalized and efficient ...
  • Erdő, Franciska; Bors, Luca Anna; Farkas, Dániel; Bajza, Ágnes; Gizurarson, Sveinbjorn (Elsevier BV, 2018-10)
    The acute or chronic drug treatments for different neurodegenerative and psychiatric disorders are challengingfrom several aspects. The low bioavailability and limited brain exposure of oral drugs, the rapid metabolism,elimination, the unwanted side ...
  • Schepsky, Alexander; Traustadóttir, Gunnhildur Ásta; Jóelsson, Jón Pétur; Ingþórsson, Sævar; Kricker, Jennifer; Bergthorsson, Jon Thor; Ásbjarnarson, Árni; Gudjonsson, Thorkell; Nupponen, Nina; Slipicevic, Ana; Lehmann, Fredrik; Gudjonsson, Thorarinn (Wiley, 2020-07-27)
    Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide-conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells, where it is ...
  • Palsson, Olafur; Löve, Þorvarður Jón; Gunnarsdóttir, Anna Ingibjörg; Gunnarsson, Pétur Sigurður; Rúnarsdóttir, Eydís Erla; Krogh, Niels Steen; Gudbjornsson, Bjorn (BMJ, 2019-07)
    Objectives To determine in a retrospective cohort whether patients with psoriatic arthritis (PsA) who would not have fulfilled the inclusion criteria for randomised controlled trials (RCTs) for the TNF inhibitor (TNFi) chosen for their treatment (excl) ...
  • Cohen, Jacqueline M.; Cesta, Carolyn E.; Furu, Kari; Einarsdóttir, Kristjana; Gissler, Mika; Havard, Alys; Hernandez‐Diaz, Sonia; Huybrechts, Krista F.; Kieler, Helle; Leinonen, Maarit K.; Li, Jiong; Reutfors, Johan; Schaffer, Andrea; Selmer, Randi; Yu, Yongfu; Zoega, Helga; Karlstad, Øystein (Wiley, 2020-06-03)
    Purpose: To describe recent international trends in antiepileptic drug (AED) use during pregnancy and individual patterns of use including discontinuation and switching. Methods: We studied pregnancies from 2006 to 2016 within linked population-based ...