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Fletta eftir efnisorði "Lyfjafræði"
Atriði 1-20 af 35
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2-Hydroxypropyl-β-Cyclodextrin Aggregates: Identification and Development of Analytical Techniques (MDPI AG, 2018-10-13)It is extremely important for pharmaceutical formulators to have analytical methodology that provides efficient detection and quantification of HPβCD aggregates. Five different methods were then evaluated for their potential to detect these aggregates ... -
(MDPI AG, 2018-11-08)An UPLC-qTOF-MS-based dereplication study led to the targeted isolation of seven bromoindole alkaloids from the sub-Arctic sponge Geodia barretti. This includes three new metabolites, namely geobarrettin A–C (1–3) and four known compounds, barettin ...
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(Elsevier BV, 2019-04)The club moss family Lycopodiaceae produces a diverse array of bioactive lycopodium alkaloids (LAs). In particular, the alkaloid huperzine A (hupA) has grasped attention since it is a potent acetylcholinesterase inhibitor of medical interest in Alzheimer's ...
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(Wiley, 2019-07-07)Aims: We investigated anticholinergic medicines use among older adults initiating dementia medicines. Methods: We used Pharmaceutical Benefits Scheme dispensing claims to identify patients who initiated donepezil, rivastigmine, galantamine or memantine ...
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(MDPI AG, 2018-08-04)Diatoms are a major group of unicellular algae that are rich in lipids and carotenoids. However, sustained research efforts are needed to improve the strain performance for high product yields towards commercialization. In this study, we generated a ...
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(Elsevier, 2022-02)A new synthesis method was developed and optimized by a full factorial design for conjugating hydroxycinnamic acids (HCA-s) to chitosan. Cinnamic acid and tert-butyldimethylsilyl protected HCA-s were converted to their corresponding acyl chlorides ...
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(Rockefeller University Press, 2019-04-15)γ-aminobutyric acid type A receptors (GABAARs), the major inhibitory neurotransmitter receptors in the mammalian central nervous system, are arguably the most challenging member of the pentameric Cys-loop receptors to study due to their heteromeric ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2019-06)In the course of a nearly century-long global effort to discover new bacterialderived drugs from the environment, there have been few innovations to the way that researchers have collected samples and subsequently created microbial libraries sourced ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2020-11)Background: Age-related macular degeneration (AMD) causes vision loss in elderly people due to neovascularization. The first line treatments are intravitreal injections which can induce severe pain. Oral administration still produces side effects. ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2020-10-26)Ocular drug delivery is very challenging due to the anatomical and physiological barriers of the eye. Poor aqueous solubility of many drugs and short retention time at ocular surfaces makes the formulation of topical dosage forms even more challenging. ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2022-02)Sýklódextrín eru hjálparefni sem notuð eru lyfjaform svo sem vatnslausnir (t.d. stungulyf) og föst lyfjaform (t.d. töflur), til að auka leysanleika, stöðugleika og aðgengi lyfjanna. Í þessu verkefni var notkun sýklódextrína sem hjálparefni í augndropum ...
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(MDPI AG, 2019-05-15)Natamycin is the only drug approved for fungal keratitis treatment, but its low water solubility and low ocular penetration limit its efficacy. The purpose of this study was to overcome these limitations by encapsulating the drug in single or mixed ...
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(MDPI AG, 2018-12-13)Fluoropyrimidine-based chemotherapy is extensively used for the treatment of solid cancers, including colorectal cancer. However, fluoropyrimidine-driven toxicities are a major problem in the management of the disease. The grade and type of the ...
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(Wiley, 2020-02-17)Objectives: The aim of the present superiority study was to determine the effect of systemic antibiotics primarily on patient-reported outcome measures (PROMs) and post-surgical complications in patients undergoing oral implant therapy with simultaneous ...
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(2021-06)BACKGROUND: Emu Oil (EO) previously demonstrated therapeutic potential in a mouse model of colitis-associated CRC (CA-CRC). Saireito, a traditional Japanese medicine, has not been investigated in CA-CRC. AIM: To determine whether EO and Saireito could ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2018-12)The ocean represents a tremendous source of biologically active metabolites with great potential for the development of new pharmaceuticals. Marine sponges and their microbial associates are known as the most prolific source of structurally diverse and ...
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(University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2022-09)gamma-Cyclodextrin (gCD) has been recently used as pharmaceutical excipient in topical formulation for ocular delivery. The high corticosteroid concentration in various ocular tissues has been reported after topical application of aqueous eye drops, ...
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(Georg Thieme Verlag KG, 2015-07-17)The genus Diphasiastrum includes at least 23 species distributed primarily across the northern temperate and subarctic areas of the world. These plants produce an array of lycopodium alkaloids, and some species such as Diphasiastrum complanatum have ...
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(Georg Thieme Verlag KG, 2018-10-05)The alkaloids huperzine A and huperzine B were originally isolated from the Chinese club moss Huperzia serrata. They are known inhibitors of acetylcholinesterase, and especially huperzine A shows pharmaceutical potential for the treatment of Alzheimerʼs ...
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(Springer Nature, 2017-05-11)Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as ...
Atriði 1-20 af 35