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Browsing by Subject "Lífefnafræði"

Browsing by Subject "Lífefnafræði"

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  • Xu, Maonian; Eiriksson, Finnur Freyr; Thorsteinsdóttir, Margrét; Heiðmarsson, Starri; Omarsdottir, Sesselja; Olafsdottir, Elin Soffia (Elsevier BV, 2019-04)
    The club moss family Lycopodiaceae produces a diverse array of bioactive lycopodium alkaloids (LAs). In particular, the alkaloid huperzine A (hupA) has grasped attention since it is a potent acetylcholinesterase inhibitor of medical interest in Alzheimer's ...
  • Eysteinsson, Thor; Guðmundsdóttir, Hrönn; Harðarson, Arnar Össur; Berrino, Emanuela; Selleri, Silvia; Supuran, Claudiu; carta, fabrizio (MDPI AG, 2019-01-22)
    Carbonic anhydrase inhibitors (CAIs), such as dorzolamide (DZA), are used as anti-glaucoma drugs to lower intraocular pressure, but it has been found that some of these drugs act as vasodilators of retinal arteries. The exact mechanism behind the ...
  • Ara, Kazi Zubaida Gulshan; Månberger, Anna; Gabriško, Marek; Linares-Pastén, Javier A.; Jasilionis, Andrius; Friðjónsson, Ólafur H.; Hreggvidsson, Gudmundur Oli; Janeček, Štefan; Karlsson, Eva Nordberg (Springer Science and Business Media LLC, 2020-01-28)
    The genome of Rhodothermus marinus DSM 4253 encodes six glycoside hydrolases (GH) classified under GH family 3 (GH3): RmBgl3A, RmBgl3B, RmBgl3C, RmXyl3A, RmXyl3B and RmNag3. The biochemical function, modelled 3D-structure, gene cluster and evolutionary ...
  • Ron, Emanuel Y. C.; Plaza, Merichel; Kristjánsdóttir, Þórdís; Sardari, Roya R. R.; Björnsdóttir, Snædís; Guðmundsson, Steinn; Hreggvidsson, Gudmundur Oli; Turner, Charlotta; van Niel, Ed W. J.; Nordberg-Karlsson, Eva (Wiley-Blackwell, 2017-10-17)
    Rhodothermus marinus, a marine aerobic thermophile, was first isolated from an intertidal hot spring in Iceland. In recent years, the R. marinus strain PRI 493 has been genetically modified, which opens up possibilities for targeted metabolic engineering ...
  • Hjörleifsson, Jens G; Ásgeirsson, Bjarni (Wiley, 2018-12-21)
    Most enzymes are homodimers or higher order multimers. Cold‐active alkaline phosphatase from Vibrio splendidus (VAP) transitions into a dimer with very low activity under mild denaturation conditions. The desire to understand why this dimer fails to ...
  • Hjörleifsson, Jens G; Ásgeirsson, Bjarni (Elsevier BV, 2016-07)
    Alkaline phosphatase is a homodimeric metallo-hydrolase where both Zn2+ and Mg2+ are important for catalysis and stability. Cold-adapted alkaline phosphatase variants have high activity at low temperatures and lower thermal stability compared with ...
  • Sigmarsdóttir, Þóra; McGarrity, Sarah; Rolfsson, Óttar; Yurkovich, James T.; Sigurjónsson, Ólafur E. (Frontiers Media SA, 2020-03-31)
    Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct ...
  • Kapralova, Kalina; Guðbrandsson, Jóhannes; Reynisdottir, Sigrun; Santos, Cristina B.; Baltanás, Vanessa C; Maier, Valerie H. untranslated; Snorrason, Sigurður S.; Palsson, Arnar (Public Library of Science (PLoS), 2013-07-24)
    Northern freshwater fish may be suitable for the genetic dissection of ecological traits because they invaded new habitats after the last ice age (∼10.000 years ago). Arctic charr (Salvelinus alpinus) colonizing streams and lakes in Iceland gave rise ...
  • Chakraborty, Sandeep; Rendón-Ramírez, Adela; Ásgeirsson, Bjarni; Dutta, Mouparna; Ghosh, Anindya S.; Oda, Masataka; Venkatramani, Ravindra; Rao, Basuthkar J.; Dandekar, Abhaya M.; Goñi, Félix M. (F1000Research, 2015-01-29)
    The long term side effects of any newly introduced drug is a subject of intense research, and often raging controversies. One such example is the dipeptidyl peptidase-IV (DPP4) inhibitor used for treating type 2 diabetes, which is inconclusively ...
  • Bordbar, Aarash; Yurkovich, James T.; Paglia, Giuseppe; Rolfsson, Óttar; Sigurjónsson, Ólafur E.; Palsson, Bernhard O. (Springer Nature, 2017-04-07)
    The increasing availability of metabolomics data necessitates novel methods for deeper data analysis and interpretation. We present a flux balance analysis method that allows for the computation of dynamic intracellular metabolic changes at the cellular ...
  • Stefánsson, Bjarki; Sandholt, Gunnar Birgir; Guðmundsdóttir, Ágústa (Elsevier BV, 2017-01)
    Trypsins from Atlantic cod (Gadus morhua), consisting of several isoenzymes, are highly active cold-adapted serine proteases. These trypsins are isolated for biomedical use in an eco-friendly manner from underutilized seafood by-products. Our group has ...
  • Salazar, Alejandro; Rousk, Kathrin; Jónsdóttir, Ingibjörg Svala; Bellenger, Jean‐Philippe; Andrésson, Ólafur (Wiley, 2019-12-31)
    Warming can alter the biogeochemistry and ecology of soils. These alterations can be particularly large in high northern latitude ecosystems, which are experiencing the most intense warming globally. In this meta‐analysis, we investigated global trends ...
  • Chades, Theo; Scully, Sean; Ingvadóttir, Eva María; Orlygsson, Johann (Frontiers Media SA, 2018-08-20)
    Mannitol-containing macro algae biomass, such as Ascophyllum nodosum and Laminaria digitata, are a potential feedstock for the production of biofuels such as bioethanol. The purpose of this work was to evaluate the ability of thermophilic anaerobes ...
  • Ludwig, Michael Z; Palsson, Arnar; Alekseeva, Elena; Bergman, Casey M; Nathan, Janaki; Kreitman, Martin (Public Library of Science (PLoS), 2005-03-15)
    Lack of knowledge about how regulatory regions evolve in relation to their structure–function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences. To address this we applied reverse genetics to carry out a ...
  • Gargallo-Garriga, Albert; Ayala-Roque, Marta; Sardans, Jordi; Bartrons, Mireia; Granda, Victor; Sigurdsson, Bjarni D.; Leblans, Niki; Oravec, Michal; Urban, Otmar; Janssens, Ivan; Penuelas, Josep (MDPI AG, 2017-08-23)
    Climate change is stronger at high than at temperate and tropical latitudes. The natural geothermal conditions in southern Iceland provide an opportunity to study the impact of warming on plants, because of the geothermal bedrock channels that induce ...
  • Hjörleifsson, Jens G (Jens Guðmundur Hjörleifsson, 2018-06-06)
    Protein quaternary structures are fundament for life. Proteins have evolved towards large assemblies of subunits needed for the execution of complex chemistry, for building structural components or for compartmentalization. Most oligomeric enzymes ...
  • Óskarsson, Kristinn Ragnar (University of Iceland, School of Engineering and Natural Sciences, Faculty of Physical Sciences, 2020-10)
    Life on earth is found everywhere where water is found, meaning that life has adapted to extremely varied environments. Thus, protein structures must adapt to a myriad of environmental stressors while maintaining their functional forms. In the case ...
  • Wesolowska, Natalia; Reynisdóttir, Sigrún; Ludwig, Michael Z.; Kreitman, Martin; Palsson, Arnar (Public Library of Science (PLoS), 2014-05-01)
    Changes in regulatory DNA contribute to phenotypic differences within and between taxa. Comparative studies show that many transcription factor binding sites (TFBS) are conserved between species whereas functional studies reveal that some mutations ...
  • Hjörleifsson, Jens G; Ásgeirsson, Bjarni (American Chemical Society (ACS), 2017-09-07)
    The effect of ionic strength on enzyme activity and stability varies considerably between enzymes. Ionic strength is known to affect the catalytic activity of some alkaline phosphatases (APs), such as Escherichia coli AP, but how ions affect APs is ...
  • Gudmundsdottir, Bjorg; Gudmundsson, Kristbjorn Orri; Klarmann, Kimberly D.; Singh, Satyendra K.; Sun, Lei; Singh, Shweta; Du, Yang; Coppola, Vincenzo; Stockwin, Luke; Nguyen, Nhu; Tessarollo, Lino; Thorsteinsson, Leifur; Sigurjonsson, Olafur; Gudmundsson, Sveinn Vidar; Rafnar, Thorunn; Tisdale, John F.; Keller, Jonathan R. (Elsevier BV, 2018-06-12)
    Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia. We identified a zinc-finger ...