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Browsing by Subject "Immunology"

Browsing by Subject "Immunology"

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    Abatacept in rheumatoid arthritis : Survival on drug, clinical outcomes, and their predictors - Data from a large national quality register 
    Cagnotto, Giovanni; Willim, Minna; Nilsson, Jan Åke; Compagno, Michele; Jacobsson, Lennart T.H.; Saevarsdottir, Saedis; Turesson, Carl (2020-01-22)
    Background: There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inhibition in clinical practice. ...
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    The adjuvants dmLT and mmCT enhance humoral immune responses to a pneumococcal conjugate vaccine after both parenteral or mucosal immunization of neonatal mice 
    Molina Estupiñan, Jenny Lorena; Pind, Auður Anna Aradóttir; Pajoohian, Poorya Foroutan; Jónsdóttir, Ingileif; Bjarnarson, Stefanía P (2023-01-20)
    Immaturity of the neonatal immune system contributes to increased susceptibility to infectious diseases and poor vaccine responses. Therefore, better strategies for early life vaccination are needed. Adjuvants can enhance the magnitude and duration of ...
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    Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells : Implications for a Bacterial Origin in RA Etiology 
    Sherina, Natalia; de Vries, Charlotte; Kharlamova, Nastya; Sippl, Natalie; Jiang, Xia; Brynedal, Boel; Kindstedt, Elin; Hansson, Monika; Mathsson-Alm, Linda; Israelsson, Lena; Stålesen, Ragnhild; Saevarsdottir, Saedis; Holmdahl, Rikard; Hensvold, Aase; Johannsen, Gunnar; Eriksson, Kaja; Sallusto, Federica; Catrina, Anca I.; Rönnelid, Johan; Grönwall, Caroline; Yucel-Lindberg, Tülay; Alfredsson, Lars; Klareskog, Lars; Piccoli, Luca; Malmström, Vivianne; Amara, Khaled; Lundberg, Karin (2022-04-20)
    Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated ...
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    Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritis : results from the SWEFOT trial population 
    for the SWEFOT study group (2019-09-03)
    Objective: Infliximab-treated patients with rheumatoid arthritis (RA) may respond insufficiently due to low serum infliximab (sIFX) levels, caused by anti-drug antibodies (ADAs). However, monitoring of sIFX and ADAs is not routinely implemented, and ...
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    Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39 
    Spiliopoulou, Athina; Colombo, Marco; Plant, Darren; Nair, Nisha; Cui, Jing; Coenen, Marieke J.H.; Ikari, Katsunori; Yamanaka, Hisashi; Saevarsdottir, Saedis; Padyukov, Leonid; Bridges, S. Louis; Kimberly, Robert P.; Okada, Yukinori; Van Riel, Piet L.C.M.; Wolbink, Gertjan; Van Der Horst-Bruinsma, Irene E.; De Vries, Niek; Tak, Paul P.; Ohmura, Koichiro; Canhão, Helena; Guchelaar, Henk Jan; Huizinga, Tom W.J.; Criswell, Lindsey A.; Raychaudhuri, Soumya; Weinblatt, Michael E.; Wilson, Anthony G.; Mariette, Xavier; Isaacs, John D.; Morgan, Ann W.; Pitzalis, Costantino; Barton, Anne; Mckeigue, Paul (2019-08-01)
    Objectives We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness of these ...
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    Autoimmunity, Infections, and the Risk of Monoclonal Gammopathy of Undetermined Significance 
    Sigurbergsdóttir, Aðalbjörg Ýr; Löve, Þorvarður Jón; Kristinsson, Sigurður Yngvi (2022-04-28)
    Various epidemiological studies, including case reports and -series in addition to larger, population-based studies, have reported an increased prevalence of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma in individuals ...
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    Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements : Results From the UK Biobank Resource 
    Styrkarsdottir, Unnur; Lund, Sigrun H; Thorleifsson, Gudmar; Saevarsdottir, Saedis; Gudbjartsson, Daniel F; Thorsteinsdottir, Unnur; Stefansson, Kari (2023-04)
    OBJECTIVE: The level of cartilage acidic protein 1 (CRTAC1) in plasma was recently discovered to be associated with osteoarthritis (OA) risk and progression to joint replacement in Iceland. This study was undertaken to validate these findings in an ...
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    Characterization of MHC class I in a long distance migratory wader, the Icelandic black-tailed godwit 
    Pardal, Sara; Drews, Anna; Alves, Jose; Ramos, Jaime A.; Westerdahl, Helena (Springer Nature, 2017-05-23)
    The major histocompatibility complex (MHC) encodes proteins that are central for antigen presentation and pathogen elimination. MHC class I (MHC-I) genes have attracted a great deal of interest among researchers in ecology and evolution and have been ...
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    Comorbidities and chance of remission in patients with early rheumatoid arthritis receiving methotrexate as first-line therapy : a Swedish observational nationwide study 
    Tidblad, Liselotte; Westerlind, Helga; Delcoigne, Bénédicte; Askling, Johan; Saevarsdottir, Saedis (2023-12-20)
    OBJECTIVES: This study aims to examine whether comorbidities affect the likelihood of reaching primary remission on methotrexate monotherapy as the first disease-modifying antirheumatic drug (DMARD) in early rheumatoid arthritis (RA). METHODS: We used ...
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    Comparative effectiveness of anti-IL5 and anti-IgE biologic classes in patients with severe asthma eligible for both 
    Pfeffer, Paul E; Ali, Nasloon; Murray, Ruth; Ulrik, Charlotte; Tran, Trung N; Maspero, Jorge; Peters, Matthew; Christoff, George C; Sadatsafavi, Mohsen; Torres-Duque, Carlos A; Altraja, Alan; Lehtimäki, Lauri; Papadopoulos, Nikolaos G; Salvi, Sundeep; Costello, Richard W; Cushen, Breda; Heffler, Enrico; Iwanaga, Takashi; Al-Ahmad, Mona; Larenas-Linnemann, Désirée; Kuna, Piotr; Fonseca, João A; Al-Lehebi, Riyad; Rhee, Chin Kook; Perez-de-Llano, Luis; Perng Steve, Diahn-Warng; Mahboub, Bassam; Wang, Eileen; Goh, Celine; Lyu, Juntao; Newell, Anthony; Alacqua, Marianna; Belevskiy, Andrey S; Bhutani, Mohit; Bjermer, Leif; Björnsdóttir, Unnur Steina; Bourdin, Arnaud; Bulow, Anna von; Busby, John; Canonica, Giorgio Walter; Cosio, Borja G; Dorscheid, Delbert R; Muñoz-Esquerre, Mariana; FitzGerald, J Mark; Gil, Esther Garcia; Gibson, Peter G; Heaney, Liam G; Hew, Mark; Hilberg, Ole; Hoyte, Flavia; Jackson, David J; Koh, Mariko Siyue; Ko, Hsin-Kuo Bruce; Lee, Jae Ha; Lehmann, Sverre; Chaves Loureiro, Cláudia; Lúðvíksdóttir, Dóra; Menzies-Gow, Andrew N; Mitchell, Patrick; Papaioannou, Andriana I; Popov, Todor A; Porsbjerg, Celeste M; Salameh, Laila; Sirena, Concetta; Taillé, Camille; Taube, Christian; Tohda, Yuji; Wechsler, Michael E; Price, David B (2023-07)
    BACKGROUND: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients with severe asthma eligible ...
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    A comparative study of adjuvants effects on neonatal plasma cell survival niche in bone marrow and persistence of humoral immune responses 
    Pind, Auður Anna Aradóttir; Thorsdottir, Sigrun; Magnusdottir, Gudbjorg Julia; Meinke, Andreas; Del Giudice, Giuseppe; Jónsdóttir, Ingileif; Bjarnarson, Stefanía P (2022-08-03)
    The neonatal immune system is distinct from the immune system of older individuals rendering neonates vulnerable to infections and poor responders to vaccination. Adjuvants can be used as tools to enhance immune responses to co-administered antigens. ...
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    Component-resolved microarray analysis of IgE sensitization profiles to Culicoides recombinant allergens in horses with insect bite hypersensitivity 
    Novotny, Ella N.; White, Samuel J.; Wilson, A. Douglas; Stefánsdóttir, Sara Björk; Tijhaar, Edwin; Jónsdóttir, Sigríður; Frey, Rebekka; Reiche, Dania; Rose, Horst; Rhyner, Claudio; Schüpbach-Regula, Gertraud; Þorsteinsdóttir, Sigurbjörg; Alcocer, Marcos; Marti, Eliane (2021-04)
    Background: Allergy to bites of blood-sucking insects, including biting midges, can affect both human and veterinary patients. Horses are often suffering from an IgE-mediated allergic dermatitis caused by bites of midges (Culicoides spp). With the aim ...
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    A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis 
    Grönwall, Caroline; Liljefors, Lisa; Bang, Holger; Hensvold, Aase H.; Hansson, Monika; Mathsson-Alm, Linda; Israelsson, Lena; Joshua, Vijay; Svärd, Anna; Stålesen, Ragnhild; Titcombe, Philip J.; Steen, Johanna; Piccoli, Luca; Sherina, Natalia; Clavel, Cyril; Svenungsson, Elisabet; Gunnarsson, Iva; Sævarsdóttir, Sædís; Kastbom, Alf; Serre, Guy; Alfredsson, Lars; Malmström, Vivianne; Rönnelid, Johan; Catrina, Anca I.; Lundberg, Karin; Klareskog, Lars (2021-05-20)
    Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet, other serum anti-modified protein autoantibodies (AMPA), e.g. ...
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    Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells 
    Káradóttir, Harpa; Nikhil Nitin, Kulkarn; Guðjónsson, Þórarinn; Karason, Sigurbergur; Guðmundsson, Guðmundur Hrafn (PeerJ, 2015-12-07)
    Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense ...
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    Detailed Multiplex Analysis of SARS-CoV-2 Specific Antibodies in COVID-19 Disease 
    Brynjólfsson, Siggeir Fannar; Sigurgrímsdóttir, Hildur; Einarsdóttir, Elín D.; Björnsdóttir, Guðrún Ása; Ármannsdóttir, Brynja; Baldvinsdóttir, Guðrún E.; Bjarnason, Agnar; Guðlaugsson, Ólafur; Guðmundsson, Sveinn Viðar; Sigurðardóttir, Sigurveig T.; Löve, Arthur; Kristinsson, Karl Gústaf; Lúðvíksson, Björn Rúnar (2021-06-10)
    A detailed understanding of the antibody response against SARS-CoV-2 is of high importance, especially with the emergence of novel vaccines. A multiplex-based assay, analyzing IgG, IgM, and IgA antibodies against the receptor binding domain (RBD), spike ...
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    Development of classification criteria for hand osteoarthritis : Comparative analyses of persons with and without hand osteoarthritis 
    Haugen, Ida K.; Felson, David T.; Abhishek, Abhishek; Berenbaum, Francis; Bierma-Zeinstra, Sita; Borgen, Tove; Herrero Beaumont, Gabriel; Ishimori, Mariko; Jonsson, Helgi; Kroon, Féline P.B.; Maheu, Emmanuel; Ramonda, Roberta; Ritschl, Valentin; Stamm, Tanja A.; Van Der Heijde, Desirée; Wittoek, Ruth; Greibrokk, Elsie; Smeets, Wilma; Kloppenburg, Margreet (2020-06-25)
    Objectives Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA. Methods In a cross-sectional multi-centre international study, a convenience sample of patients ...
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    Development of radiographic classification criteria for hand osteoarthritis : a methodological report (Phase 2) 
    Haugen, Ida K.; Felson, David; Abhishek, Abhishek; Berenbaum, Francis; Edwards, John James; Herrero Beaumont, Gabriel; Hermann-Eriksen, Merete; Hill, Catherine L.; Ishimori, Mariko; Jónsson, Helgi; Karjalainen, Teemu; Leung, Ying Ying; Maheu, Emmanuel; Mallen, Christian D.; Moe, Rikke Helene; Ramonda, Roberta; Ritschl, Valentin; Stamm, Tanja A.; Szekanecz, Zoltan; van der Giesen, Florus J.; Ritt, Marco J.P.F.; Wittoek, Ruth; Kjeken, Ingvild; Osteras, Nina; van de Stadt, Lotte A.; Englund, Martin; Dziedzic, Krysia S.; Marshall, M.; Bierma-Zeinstra, Sita; Hansen, Paul; Greibrokk, Elsie; Smeets, Wilma; Kloppenburg, Margreet (2022-02-04)
    ObjectivesIn Phase 1 of developing new hand osteoarthritis (OA) classification criteria, features associated with hand OA were identified in a population with hand complaints. Radiographic findings could better discriminate patients with hand OA and ...
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    Dietary Fish Oil Increases the Number of CD11b+CD27− NK Cells at the Inflammatory Site and Enhances Key Hallmarks of Resolution of Murine Antigen-Induced Peritonitis 
    Jensen, Kirstine Nolling; Heijink, Marieke; Giera, Martin; Freysdóttir, Jóna; Harðardóttir, Ingibjörg (2022-01-01)
    Purpose: To determine the effects of dietary omega-3 polyunsaturated fatty acids (PUFAs) on recruitment of natural killer (NK) cells and resolution responses in antigen-induced peritonitis in mice. Methods: Mice were fed fish oil-enriched or control ...
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    Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component? 
    Sysojev, Anton Öberg; Frisell, Thomas; Delcoigne, Bénédicte; Saevarsdottir, Saedis; Askling, Johan; Westerlind, Helga (2022-08-06)
    Objectives: To assess whether persistence to treatment with methotrexate (MTX) in early rheumatoid arthritis (RA) is shared among first-degree relatives with RA and to estimate any underlying heritability. Methods: First-degree relative pairs diagnosed ...
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    Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration 
    Lindström, Ulf; Di Giuseppe, Daniela; Delcoigne, Bénédicte; Glintborg, Bente; Möller, Burkhard; Ciurea, Adrian; Pombo-Suarez, Manuel; Sanchez-Piedra, Carlos; Eklund, Kari; Relas, Heikki; Guðbjörnsson, Björn; Löve, Þorvarður Jón; Jones, Gareth T.; Codreanu, Catalin; Ionescu, Ruxandra; Nekvindova, Lucie; Závada, Jakub; Atas, Nuh; Yolbas, Servet; Fagerli, Karen Minde; Michelsen, Brigitte; Rotar, Ziga; Tomšič, Matija; Iannone, Florenzo; Santos, Maria Jose; Avila-Ribeiro, Pedro; Ørnbjerg, Lykke Midtbøll; Østergaard, Mikkel; Jacobsson, Lennart T.H.; Askling, Johan; Nissen, Michael J. (2021-06-03)
    Background Comedication with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) during treatment with tumour necrosis factor inhibitors (TNFi) is extensively used in psoriatic arthritis (PsA), although the additive benefit remains ...