Opin vísindi

Fletta eftir efnisorði "Genome-wide association studies"

Fletta eftir efnisorði "Genome-wide association studies"

Röðun: Raða: Niðurstöður:

  • Icon
    1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function 
    Gorski, Mathias; van der Most, Peter J.; Teumer, Alexander; Chu, Audrey Y.; Li, Man; Mijatovic, Vladan; Nolte, Ilja M.; Cocca, Massimiliano; Taliun, Daniel; Gomez, Felicia; Li, Yong; Tayo, Bamidele; Tin, Adrienne; Feitosa, Mary F.; Aspelund, Thor; Attia, John; Biffar, Reiner; Bochud, Murielle; Boerwinkle, Eric; Borecki, Ingrid; Bottinger, Erwin P.; Chen, Ming-Huei; Chouraki, Vincent; Ciullo, Marina; Coresh, Josef; Cornelis, Marilyn C.; Curhan, Gary C.; d’Adamo, Adamo Pio; Dehghan, Abbas; Dengler, Laura; Ding, Jingzhong; Eiríksdóttir, Guðný; Endlich, Karlhans; Enroth, Stefan; Esko, Tõnu; Franco, Oscar H.; Gasparini, Paolo; Gieger, Christian; Girotto, Giorgia; Gottesman, Omri; Gudnason, Vilmundur; Gyllensten, Ulf; Hancock, Stephen J.; Harris, Tamara B.; Helmer, Catherine; Höllerer, Simon; Hofer, Edith; Hofman, Albert; Holliday, Elizabeth G.; Homuth, Georg; Hu, Frank B.; Huth, Cornelia; Hutri-Kähönen, Nina; Hwang, Shih-Jen; Imboden, Medea; Johansson, Åsa; Kähönen, Mika; König, Wolfgang; Kramer, Holly; Krämer, Bernhard K.; Kumar, Ashish; Kutalik, Zoltán; Lambert, Jean-Charles; Launer, Lenore J.; Lehtimäki, Terho; de Borst, Martin; Navis, Gerjan; Swertz, Morris; Liu, Yongmei; Lohman, Kurt; Loos, Ruth J. F.; Lu, Yingchang; Lyytikäinen, Leo-Pekka; McEvoy, Mark A.; Meisinger, Christa; Meitinger, Thomas; Metspalu, Andres; Metzger, Marie; Mihailov, Evelin; Mitchell, Paul; Nauck, Matthias; Oldehinkel, Albertine J.; Olden, Matthias; WJH Penninx, Brenda; Pistis, Giorgio; Pramstaller, Peter P.; Probst-Hensch, Nicole; Raitakari, Olli T.; Rettig, Rainer; Ridker, Paul M.; Rivadeneira, Fernando; Robino, Antonietta; Rosas, Sylvia E.; Ruderfer, Douglas; Ruggiero, Daniela; Saba, Yasaman; Sala, Cinzia; Schmidt, Helena; Schmidt, Reinhold; Scott, Rodney J.; Sedaghat, Sanaz; Smith, Albert Vernon; Sorice, Rossella; Stengel, Benedicte; Stracke, Sylvia; Strauch, Konstantin; Toniolo, Daniela; Uitterlinden, André G.; Ulivi, Sheila; Viikari, Jorma S.; Völker, Uwe; Vollenweider, Peter; Völzke, Henry; Vuckovic, Dragana; Waldenberger, Melanie; Jin Wang, Jie; Yang, Qiong; Chasman, Daniel I.; Tromp, Gerard; Snieder, Harold; Heid, Iris M.; Fox, Caroline S.; Köttgen, Anna; Pattaro, Cristian; Böger, Carsten A.; Fuchsberger, Christian (Springer Nature, 2017-04-28)
    HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The ...
  • Icon
    Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry 
    Sapkota, Yadav; De Vivo, Immaculata; Steinthorsdottir, Valgerdur; Fassbender, Amelie; Bowdler, Lisa; Buring, Julie E.; Edwards, Todd L.; Jones, Sarah; Dorien, O.; Peterse, Danielle; Rexrode, Kathryn M.; Ridker, Paul M.; Schork, Andrew J.; Thorleifsson, Gudmar; Wallace, Leanne M.; Kraft, Peter; Morris, Andrew P.; Nyholt, Dale R.; Edwards, Digna R. Velez; Nyegaard, Mette; D'Hooghe, Thomas; Chasman, Daniel I.; Stefansson, Kari; Missmer, Stacey A.; Montgomery, Grant W. (Springer Nature, 2017-09)
    Genome-wide association (GWA) studies have identified 19 independent common risk loci for endometriosis. Most of the GWA variants are non-coding and the genes responsible for the association signals have not been identified. Herein, we aimed to assess ...
  • Icon
    Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations 
    Daya, Michelle; Bjarnadóttir, Hrafnhildur (Springer Science and Business Media LLC, 2019-02-20)
    Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true ...
  • Icon
    The effects of sequence variants on cardiac function and disease 
    Þórólfsdóttir, Rósa B. (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-09)
    Introduction and aims: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and its complex pathophysiology is incompletely understood. At the time of beginning of this work, genome-wide association studies (GWAS) on AF had yielded ...
  • Icon
    Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations 
    Ólafsson, Sigurgeir; Stridh, Pernilla; Bos, Steffan Daniël; Ingason, Andrés; Euesden, Jack; sulem, patrick; Thorleifsson, Gudmar; Gústafsson, Ómar; Jóhannesson, Ari; Geirsson, Árni J.; Þórsson, Árni V.; Sigurgeirsson, Bárður; Ludviksson, Bjorn; Ólafsson, Elías; Kristjansdottir, Helga; Jónasson, Jón G.; Ólafsson, Jón Hjaltalín; Örvar, Kjartan B.; Benediktsson, Rafn; Bjarnason, Ragnar Grímur; Kristjánsdóttir, Sjöfn; Gislason, Thorarinn; Valdimarsson, Trausti; Mikaelsdóttir, Evgenía; Sigurðsson, Snævar; Jonsson, Stefan; Rafnar, Thorunn; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Knudsen, Gun Peggy; Celius, Elisabeth G.; Myhr, Kjell-Morten; Gröndal, Gerður; Steinsson, Kristján; Valdimarsson, Helgi; Björnsson, Sigurður; Björnsdóttir, Unnur Steina; Björnsson, Einar Stefán; Nilsson, Bjorn; Andreassen, Ole A.; Alfredsson, Lars; Hillert, Jan; Kockum, Ingrid Skelton; Másson, Gísli; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; Stefansson, Hreinn; Hjaltason, Haukur; Harbo, Hanne F.; Olsson, Tomas; Jonsdottir, Ingileif; Stefansson, Kari (Springer Nature, 2017-08-08)
    A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported ...
  • Icon
    Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium 
    Weng, Lu-Chen; Lunetta, Kathryn L.; Müller-Nurasyid, Martina; Smith, Albert Vernon; Thériault, Sébastien; Weeke, Peter E.; Barnard, John; Bis, Joshua C.; Lyytikäinen, Leo-Pekka; Kleber, Marcus E.; Martinsson, Andreas; Lin, Henry J.; Rienstra, Michiel; Trompet, Stella; Krijthe, Bouwe P.; Dörr, Marcus; Klarin, Derek; Chasman, Daniel I.; Sinner, Moritz F.; Waldenberger, Melanie; Launer, Lenore J.; Harris, Tamara B.; Soliman, Elsayed Z.; Alonso, Alvaro; Paré, Guillaume; Teixeira, Pedro L.; Denny, Joshua C.; Shoemaker, M. Benjamin; Van Wagoner, David R.; Smith, Jonathan D.; Psaty, Bruce M.; Sotoodehnia, Nona; Taylor, Kent D.; Kähönen, Mika; Nikus, Kjell; Delgado, Graciela E.; Melander, Olle; Engström, Gunnar; Yao, Jie; Guo, Xiuqing; Christophersen, Ingrid E.; Ellinor, Patrick T.; Geelhoed, Bastiaan; Verweij, Niek; Macfarlane, Peter; Ford, Ian; Heeringa, Jan; Franco, Oscar H.; Uitterlinden, André G.; Völker, Uwe; Teumer, Alexander; Rose, Lynda M.; Kääb, Stefan; Gudnason, Vilmundur; Arking, Dan E.; Conen, David; Roden, Dan M.; Chung, Mina K.; Heckbert, Susan R.; Benjamin, Emelia J.; Lehtimäki, Terho; März, Winfried; Smith, J. Gustav; Rotter, Jerome I.; van der Harst, Pim; Jukema, J. Wouter; Stricker, Bruno H.; Felix, Stephan B.; Albert, Christine M.; Lubitz, Steven A. (Springer Nature, 2017-09-12)
    It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. ...
  • Icon
    Genome-wide analysis yields new loci associating with aortic valve stenosis 
    Helgadottir, Anna; Thorleifsson, Gudmar; Grétarsdóttir, Sólveig; Stefánsson, Ólafur A.; Tragante, Vinicius; Þórólfsdóttir, Rósa B.; Jonsdottir, Ingileif; Björnsson, Þorsteinn; Steinthorsdottir, Valgerdur; Verweij, Niek; Nielsen, Jonas B.; Zhou, Wei; Folkersen, Lasse; Martinsson, Andreas; Heydarpour, Mahyar; Prakash, Siddharth; Óskarsson, Gylfi; Gudbjartsson, Tomas; Geirsson, Arnar; Olafsson, Isleifur; Sigurðsson, Emil Lárus; Almgren, Peter; Melander, Olle; Franco-Cereceda, Anders; Hamsten, Anders; Fritsche, Lars; Lin, Maoxuan; Yang, Bo; Hornsby, Whitney; Guo, Dongchuan; Brummett, Chad M.; Abecasis, Gonçalo; Mathis, Michael; Milewicz, Dianna; Body, Simon C.; Eriksson, Per; Willer, Cristen J.; Hveem, Kristian; Newton-Cheh, Christopher; Smith, J. Gustav; Danielsen, Ragnar; Thorgeirsson, Gudmundur; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; Holm, Hilma; Stefansson, Kari (Springer Nature, 2018-03-07)
    Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up ...
  • Icon
    Genome-Wide Association Analyses Highlight the Potential for Different Genetic Mechanisms for Litter Size Among Sheep Breeds 
    Xu, Song-Song; Gao, Lei; Xie, Xing-Long; Ren, Yan-Ling; Shen, Zhi-Qiang; Wang, Feng; Shen, Min; Eythorsdottir, Emma; Hallsson, Jon; Kiseleva, Tatyana; Kantanen, Juha; Li, Meng-Hua (Frontiers Media SA, 2018-04-10)
    Reproduction is an important trait in sheep breeding as well as in other livestock. However, despite its importance the genetic mechanisms of litter size in domestic sheep (Ovis aries) are still poorly understood. To explore genetic mechanisms underlying ...
  • Icon
    Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria 
    Teumer, Alexander; Li, Yong; Ghasemi, Sahar; Prins, Bram P.; Wuttke, Matthias; Hermle, Tobias; Giri, Ayush; Sieber, Karsten B.; Qiu, Chengxiang; Kirsten, Holger; Tin, Adrienne; Chu, Audrey Y.; Bansal, Nisha; Feitosa, Mary F.; Wang, Lihua; Chai, Jin-Fang; Cocca, Massimiliano; Fuchsberger, Christian; Gorski, Mathias; Hoppmann, Anselm; Horn, Katrin; Li, Man; Marten, Jonathan; Noce, Damia; Nutile, Teresa; Sedaghat, Sanaz; Sveinbjornsson, Gardar; Tayo, Bamidele O.; van der Most, Peter J.; Xu, Yizhe; Yu, Zhi; Gerstner, Lea; Ärnlöv, Johan; Bakker, Stephan J. L.; Baptista, Daniela; Biggs, Mary L.; Boerwinkle, Eric; Brenner, Hermann; Burkhardt, Ralph; Carroll, Robert J.; Chee, Miao-Li; Chee, Miao-Ling; Chen, Mengmeng; Cheng, Ching-Yu; Cook, James P.; Coresh, Josef; Corre, Tanguy; Danesh, John; de Borst, Martin H.; De Grandi, Alessandro; de Mutsert, Renée; de Vries, Aiko P. J.; Degenhardt, Frauke; Dittrich, Katalin; Divers, Jasmin; Eckardt, Kai-Uwe; Ehret, Georg; Endlich, Karlhans; Felix, Janine F.; Franco, Oscar H.; Franke, Andre; Freedman, Barry I.; Freitag-Wolf, Sandra; Gansevoort, Ron T.; Giedraitis, Vilmantas; Gögele, Martin; Grundner-Culemann, Franziska; Gudbjartsson, Daniel; Gudnason, Vilmundur; Hamet, Pavel; Harris, Tamara B.; Hicks, Andrew A.; Holm, Hilma; Foo, Valencia Hui Xian; Hwang, Shih-Jen; Ikram, M. Arfan; Ingelsson, Erik; Jaddoe, Vincent W. V.; Jakobsdottir, Johanna; Josyula, Navya Shilpa; Jung, Bettina; Kähönen, Mika; Khor, Chiea-Chuen; Kiess, Wieland; Koenig, Wolfgang; Körner, Antje; Kovacs, Peter; Kramer, Holly; Krämer, Bernhard K.; Kronenberg, Florian; Lange, Leslie A.; Langefeld, Carl D.; Lee, Jeannette Jen-Mai; Lehtimäki, Terho; Lieb, Wolfgang; Lim, Su-Chi; Lind, Lars; Lindgren, Cecilia M.; Liu, Jianjun; Loeffler, Markus; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Maranville, Joseph C.; Mascalzoni, Deborah; McMullen, Barbara; Meisinger, Christa; Meitinger, Thomas; Miliku, Kozeta; Mook-Kanamori, Dennis O.; Müller-Nurasyid, Martina; Mychaleckyj, Josyf C.; Nauck, Matthias; Nikus, Kjell; Ning, Boting; Noordam, Raymond; Connell, Jeffrey O’; Olafsson, Isleifur; Palmer, Nicholette D.; Peters, Annette; Podgornaia, Anna I.; Ponte, Belen; Poulain, Tanja; Pramstaller, Peter P.; Rabelink, Ton J.; Raffield, Laura M.; Reilly, Dermot F.; Rettig, Rainer; Rheinberger, Myriam; Rice, Kenneth M.; Rivadeneira, Fernando; Runz, Heiko; Ryan, Kathleen A.; Sabanayagam, Charumathi; Saum, Kai-Uwe; Schöttker, Ben; Shaffer, Christian M.; Shi, Yuan; Smith, Albert Vernon; Strauch, Konstantin; Stumvoll, Michael; Sun, Benjamin B.; Szymczak, Silke; Tai, E-Shyong; Tan, Nicholas Y. Q.; Taylor, Kent D.; Teren, Andrej; Tham, Yih-Chung; Thiery, Joachim; Thio, Chris H. L.; Thomsen, Hauke; Thorsteinsdottir, Unnur; Tönjes, Anke; Tremblay, Johanne; Uitterlinden, André G.; van der Harst, Pim; Verweij, Niek; Vogelezang, Suzanne; Völker, Uwe; Waldenberger, Melanie; Wang, Chaolong; Wilson, Otis D.; Wong, Charlene; Wong, Tien-Yin; Yang, Qiong; Yasuda, Masayuki; Akilesh, Shreeram; Bochud, Murielle; Böger, Carsten A.; Devuyst, Olivier; Edwards, Todd L.; Ho, Kevin; Morris, Andrew P.; Parsa, Afshin; Pendergrass, Sarah A.; Psaty, Bruce M.; Rotter, Jerome I.; Stefansson, Kari; Wilson, James G.; Susztak, Katalin; Snieder, Harold; Heid, Iris M.; Scholz, Markus; Butterworth, Adam S.; Hung, Adriana M.; Pattaro, Cristian; Köttgen, Anna (Springer Science and Business Media LLC, 2019-09-11)
    Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) ...
  • Icon
    Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits 
    van Setten, Jessica; Verweij, Niek; Mbarek, Hamdi; Niemeijer, Maartje N.; Trompet, Stella; Arking, Dan E.; Brody, Jennifer A.; Gandin, Ilaria; Grarup, Niels; Hall, Leanne M.; Hemerich, Daiane; Lyytikäinen, Leo-Pekka; Mei, Hao; Müller-Nurasyid, Martina; Prins, Bram P.; Robino, Antonietta; Smith, Albert Vernon; Warren, Helen R.; Asselbergs, Folkert W.; Boomsma, Dorret I.; Caulfield, Mark J.; Eijgelsheim, Mark; Ford, Ian; Hansen, Torben; Harris, Tamara B.; Heckbert, Susan R.; Hottenga, Jouke-Jan; Iorio, Annamaria; Kors, Jan A.; Linneberg, Allan; MacFarlane, Peter W.; Meitinger, Thomas; Nelson, Christopher P.; Raitakari, Olli T.; Silva Aldana, Claudia T.; Sinagra, Gianfranco; Sinner, Moritz; Soliman, Elsayed Z.; Stoll, Monika; Uitterlinden, Andre; van Duijn, Cornelia M.; Waldenberger, Melanie; Alonso, Alvaro; Gasparini, Paolo; Gudnason, Vilmundur; Jamshidi, Yalda; Kääb, Stefan; Kanters, Jørgen K.; Lehtimäki, Terho; Munroe, Patricia B.; Peters, Annette; Samani, Nilesh J.; Sotoodehnia, Nona; Ulivi, Sheila; Wilson, James G.; de Geus, Eco J. C.; Jukema, J. Wouter; Stricker, Bruno; van der Harst, Pim; de Bakker, Paul I. W.; Isaacs, Aaron (Springer Science and Business Media LLC, 2019-01-24)
    Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR interval). In the current study, ...
  • Icon
    Genome-wide association meta-analysis yields 20 loci associated with gallstone disease 
    Ferkingstad, Egil; Oddsson, Asmundur; Gretarsdottir, Solveig; Benonisdottir, Stefania; Thorleifsson, Gudmar; Deaton, Aimee M.; Jónsson, Stefán; Stefánsson, Ólafur A.; Norðdahl, Guðmundur L.; Zink, Florian; Arnadottir, Gudny; Gunnarsson, Bjarni; Halldorsson, Gisli; Helgadottir, Anna; Jensson, Brynjar Örn; Kristjánsson, Ragnar P.; Sveinbjornsson, Gardar; Sverrisson, Davíð A.; Másson, Gísli; Olafsson, Isleifur; Eyjólfsson, Guðmundur I.; Sigurðardóttir, Ólöf; Holm, Hilma; Jonsdottir, Ingileif; Ólafsson, Sigurður; Steingrimsdottir, Thora; Rafnar, Thorunn; Björnsson, Einar Stefán; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; sulem, patrick; Stefansson, Kari (Springer Science and Business Media LLC, 2018-11-30)
    Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genomewide association studies of gallstone disease in Iceland and the UK, totaling ...
  • Icon
    A genome-wide association study identifies genetic loci associated with specific lobar brain volumes 
    van der Lee, Sven J.; Knol, Maria J.; Chauhan, Ganesh; Satizabal, Claudia L.; Smith, Albert Vernon; Hofer, Edith; Bis, Joshua C.; Hibar, Derrek P.; Hilal, Saima; van den Akker, Erik B.; Arfanakis, Konstantinos; Bernard, Manon; Yanek, Lisa R.; Amin, Najaf; Crivello, Fabrice; Cheung, Josh W.; Harris, Tamara B.; Saba, Yasaman; Lopez, Oscar L.; Li, Shuo; van der Grond, Jeroen; Yu, Lei; Paus, Tomas; Roshchupkin, Gennady V.; Amouyel, Philippe; Jahanshad, Neda; Taylor, Kent D.; Yang, Qiong; Mathias, Rasika A.; Boehringer, Stefan; Mazoyer, Bernard; Rice, Ken; Cheng, Ching Yu; Maillard, Pauline; van Heemst, Diana; Wong, Tien Yin; Niessen, Wiro J.; Beiser, Alexa S.; Beekman, Marian; Zhao, Wanting; Nyquist, Paul A.; Chen, Christopher; Launer, Lenore J.; Psaty, Bruce M.; Ikram, M. Kamran; Vernooij, Meike W.; Schmidt, Helena; Pausova, Zdenka; Becker, Diane M.; De Jager, Philip L.; Thompson, Paul M.; van Duijn, Cornelia M.; Bennett, David A.; Slagboom, P. Eline; Schmidt, Reinhold; Longstreth, W. T.; Ikram, M. Arfan; Seshadri, Sudha; Debette, Stéphanie; Gudnason, Vilmundur; Adams, Hieab H. H.; DeCarli, Charles (Springer Science and Business Media LLC, 2019-08-02)
    Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We ...
  • Icon
    Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume 
    Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon; Bis, Joshua C.; Teumer, Alexander; Scholz, Markus; Armstrong, Nicola J.; Hofer, Edith; Saba, Yasaman; Luciano, Michelle; Bernard, Manon; Trompet, Stella; Yang, Jingyun; Gillespie, Nathan A.; van der Lee, Sven J.; Neumann, Alexander; Ahmad, Shahzad; Andreassen, Ole A.; Ames, David; Amin, Najaf; Arfanakis, Konstantinos; Bastin, Mark E.; Becker, Diane M.; Beiser, Alexa S.; Beyer, Frauke; Brodaty, Henry; Bryan, R. Nick; Bülow, Robin; Dale, Anders M.; De Jager, Philip L.; Deary, Ian J.; DeCarli, Charles; Fleischman, Debra A.; Gottesman, Rebecca F.; van der Grond, Jeroen; Gudnason, Vilmundur; Harris, Tamara B.; Homuth, Georg; Knopman, David S.; Kwok, John B.; Lewis, Cora E.; Li, Shuo; Loeffler, Markus; Lopez, Oscar L.; Maillard, Pauline; El Marroun, Hanan; Mather, Karen A.; Mosley, Thomas H.; Muetzel, Ryan L.; Nauck, Matthias; Nyquist, Paul A.; Panizzon, Matthew S.; Pausova, Zdenka; Psaty, Bruce M.; Rice, Ken; Rotter, Jerome I.; Royle, Natalie; Satizabal, Claudia L.; Schmidt, Reinhold; Schofield, Peter R.; Schreiner, Pamela J.; Sidney, Stephen; Stott, David J.; Thalamuthu, Anbupalam; Uitterlinden, Andre G.; Valdés Hernández, Maria C.; Vernooij, Meike W.; Wen, Wei; White, Tonya; Witte, A. Veronica; Wittfeld, Katharina; Wright, Margaret J.; Yanek, Lisa R.; Tiemeier, Henning; Kremen, William S.; Bennett, David A.; Jukema, J. Wouter; Paus, Tomas; Wardlaw, Joanna M.; Schmidt, Helena; Sachdev, Perminder S.; Villringer, Arno; Grabe, Hans Jörgen; Longstreth, W T; van Duijn, Cornelia M.; Launer, Lenore J.; Seshadri, Sudha; Ikram, M Arfan; Fornage, Myriam (Springer Science and Business Media LLC, 2018-09-26)
    The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic ...
  • Icon
    A genome-wide association study yields five novel thyroid cancer risk loci 
    Guðmundsson, Júlíus; Þorleifsson, Guðmar; Sigurðsson, Jón K.; Stefánsdóttir, Lilja; Jónasson, Jón G.; Guðjónsson, Sigurjón Axel; Gudbjartsson, Daniel; Másson, Gísli; Jóhannsdóttir, Hrefna; Halldórsson, Gísli H.; Stacey, Simon N.; Helgason, Hannes; sulem, patrick; Senter, Leigha; He, Huiling; Liyanarachchi, Sandya; Ringel, Matthew D.; Aguillo, Esperanza; Panadero, Angeles; Prats, Enrique; Garcia-Castaño, Almudena; De Juan, Ana; Rivera, Fernando; Xu, Li; Kiemeney, Lambertus A.; Eyjólfsson, Guðmundur I.; Sigurðardóttir, Ólöf; Ólafsson, Ísleifur; Kristvinsson, Höskuldur; Netea-Maier, Romana T.; Jónsson, Þorvaldur; Mayordomo, Jose I.; Plantinga, Theo S.; Hjartarson, Hannes; Hrafnkelsson, Jón; Sturgis, Erich M.; Þorsteinsdóttir, Unnur; Rafnar, Thorunn; de la Chapelle, Albert; Stefansson, Kari (Springer Nature, 2017-02-14)
    The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European ...
  • Icon
    Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits 
    Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S.; Ahluwalia, Tarunveer S.; Chu, Audrey Y.; Heard-Costa, Nancy L.; Lim, Elise; Perez, Jeremiah; Eicher, John D.; Kutalik, Zoltán; Xue, Luting; Mahajan, Anubha; Renström, Frida; Wu, Joseph; Qi, Qibin; Ahmad, Shafqat; Alfred, Tamuno; Amin, Najaf; Bielak, Lawrence F.; Bonnefond, Amélie; Bragg, Jennifer; Cadby, Gemma; Chittani, Martina; Coggeshall, Scott; Corre, Tanguy; Direk, Nese; Eriksson, Joel; Fischer, Krista; Gorski, Mathias; Neergaard Harder, Marie; Horikoshi, Momoko; Huang, Tao; Huffman, Jennifer E.; Jackson, Anne U.; Justesen, Johanne Marie; Kanoni, Stavroula; Kinnunen, Leena; Kleber, Marcus E.; Komulainen, Pirjo; Kumari, Meena; Lim, Unhee; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Middelberg, Rita P. S.; Müller-Nurasyid, Martina; Navarro, Pau; Pérusse, Louis; Pervjakova, Natalia; Sarti, Cinzia; Smith, Albert Vernon; Smith, Jennifer A.; Stančáková, Alena; Strawbridge, Rona J.; Stringham, Heather M.; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W.; van der Most, Peter J.; Van Vliet-Ostaptchouk, Jana V.; Vedantam, Sailaja L.; Verweij, Niek; Vink, Jacqueline M.; Vitart, Veronique; Wu, Ying; Yengo, Loic; Zhang, Weihua; Hua Zhao, Jing; Zimmermann, Martina E.; Zubair, Niha; Abecasis, Gonçalo R.; Adair, Linda S.; Afaq, Saima; Afzal, Uzma; Bakker, Stephan J. L.; Bartz, Traci M.; Beilby, John; Bergman, Richard N.; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L.; Bottinger, Erwin; Braga, Daniele; Buckley, Brendan M.; Buyske, Steve; Campbell, Harry; Chambers, John C.; Collins, Francis; Curran, Joanne E.; de Borst, Gert J.; de Craen, Anton J. M.; de Geus, Eco J. C.; Dedoussis, George; Delgado, Graciela E.; den Ruijter, Hester M.; Eiríksdóttir, Guðný; Eriksson, Anna L.; Esko, Tõnu; Faul, Jessica D.; Ford, Ian; Forrester, Terrence; Gertow, Karl; Gigante, Bruna; Glorioso, Nicola; Gong, Jian; Grallert, Harald; Grammer, Tanja B.; Grarup, Niels; Haitjema, Saskia; Hallmans, Göran; Hamsten, Anders; Hansen, Torben; Harris, Tamara B.; Hartman, Catharina A.; Hassinen, Maija; Hastie, Nicholas D.; Heath, Andrew C.; Hernandez, Dena; Hindorff, Lucia; Hocking, Lynne J.; Hollensted, Mette; Holmen, Oddgeir L.; Homuth, Georg; Jan Hottenga, Jouke; Huang, Jie; Hung, Joseph; Hutri-Kähönen, Nina; Ingelsson, Erik; James, Alan L.; Jansson, John-Olov; Jarvelin, Marjo-Riitta; Jhun, Min A.; Jørgensen, Marit E.; Juonala, Markus; Kähönen, Mika; Karlsson, Magnus; Koistinen, Heikki A.; Kolcic, Ivana; Kolovou, Genovefa; Kooperberg, Charles; Krämer, Bernhard K.; Kuusisto, Johanna; Kvaløy, Kirsti; Lakka, Timo; Langenberg, Claudia; Launer, Lenore J.; Leander, Karin; Lee, Nanette R.; Lind, Lars; Lindgren, Cecilia; Linneberg, Allan; Lobbens, Stephane; Loh, Marie; Lorentzon, Mattias; Luben, Robert; Lubke, Gitta; Ludolph-Donislawski, Anja; Lupoli, Sara; Madden, Pamela A. F.; Männikkö, Reija; Marques-Vidal, Pedro; Martin, Nicholas G.; McKenzie, Colin A.; McKnight, Barbara; Mellström, Dan; Menni, Cristina; Montgomery, Grant W.; Musk, A.W.; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M.; Oldehinkel, Albertine J.; Olden, Matthias; Ong, Ken K.; Padmanabhan, Sandosh; Peyser, Patricia A.; Pisinger, Charlotta; Porteous, David J.; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rasmussen-Torvik, Laura J.; Rawal, Rajesh; Rice, Treva; Ridker, Paul M.; Rose, Lynda M.; Bien, Stephanie A.; Rudan, Igor; Sanna, Serena; Sarzynski, Mark A.; Sattar, Naveed; Savonen, Kai; Schlessinger, David; Scholtens, Salome; Schurmann, Claudia; Scott, Robert A.; Sennblad, Bengt; Siemelink, Marten A.; Silbernagel, Günther; Slagboom, P Eline; Snieder, Harold; Staessen, Jan A.; Stott, David J.; Swertz, Morris A.; Swift, Amy J.; Taylor, Kent D.; Tayo, Bamidele O.; Thorand, Barbara; Thuillier, Dorothée; Tuomilehto, Jaakko; Uitterlinden, André G.; Vandenput, Liesbeth; Vohl, Marie-Claude; Völzke, Henry; Vonk, Judith M.; Waeber, Gérard; Waldenberger, Melanie; Westendorp, R. G. J.; Wild, Sarah; Willemsen, Gonneke; Wolffenbuttel, Bruce H. R.; Wong, Andrew; Wright, Alan F.; Zhao, Wei; Zillikens, M Carola; Baldassarre, Damiano; Balkau, Beverley; Bandinelli, Stefania; Böger, Carsten A.; Boomsma, Dorret I.; Bouchard, Claude; Bruinenberg, Marcel; Chasman, Daniel I.; Chen, Yii-DerIda; Chines, Peter S.; Cooper, Richard S.; Cucca, Francesco; Cusi, Daniele; Faire, Ulf de; Ferrucci, Luigi; Franks, Paul W.; Froguel, Philippe; Gordon-Larsen, Penny; Grabe, Hans Jörgen; Gudnason, Vilmundur; Haiman, Christopher A.; Hayward, Caroline; Hveem, Kristian; Johnson, Andrew D.; Wouter Jukema, J; Kardia, Sharon L. R.; Kivimaki, Mika; Kooner, Jaspal S.; Kuh, Diana; Laakso, Markku; Lehtimäki, Terho; Marchand, Loic Le; März, Winfried; McCarthy, Mark I.; Metspalu, Andres; Morris, Andrew P.; Ohlsson, Claes; Palmer, Lyle J.; Pasterkamp, Gerard; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Psaty, Bruce M.; Qi, Lu; Rauramaa, Rainer; Smith, Blair H.; Sørensen, Thorkild I. A.; Strauch, Konstantin; Tiemeier, Henning; Tremoli, Elena; van der Harst, Pim; Vestergaard, Henrik; Vollenweider, Peter; Wareham, Nicholas J.; Weir, David R.; Whitfield, John B.; Wilson, James F.; Tyrrell, Jessica; Frayling, Timothy M.; Barroso, Inês; Boehnke, Michael; Deloukas, Panagiotis; Fox, Caroline S.; Hirschhorn, Joel N.; Hunter, David J.; Spector, Tim D.; Strachan, David P.; van Duijn, Cornelia M.; Heid, Iris M.; Mohlke, Karen L.; Marchini, Jonathan; Loos, Ruth J. F.; Kilpeläinen, Tuomas O.; Liu, Ching-Ti; Borecki, Ingrid; North, Kari E.; Cupples, L Adrienne (Springer Nature, 2017-04-26)
    Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 ...
  • Icon
    Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults 
    Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renström, Frida; Quaye, Lydia; Eicher, John D.; Hayes, James E.; Cornelis, Marilyn; Kutalik, Zoltán; Lim, Elise; Luan, Jian’an; Huffman, Jennifer E.; Zhang, Weihua; Zhao, Wei; Griffin, Paula J.; Haller, Toomas; Ahmad, Shafqat; Marques-Vidal, Pedro M.; Bien, Stephanie A.; Yengo, Loic; Teumer, Alexander; Smith, Albert Vernon; Kumari, Meena; Harder, Marie Neergaard; Justesen, Johanne Marie; Kleber, Marcus E.; Hollensted, Mette; Lohman, Kurt; Rivera, Natalia V.; Whitfield, John B.; Zhao, Jing Hua; Stringham, Heather M.; Lyytikäinen, Leo-Pekka; Huppertz, Charlotte; Willemsen, Gonneke; Peyrot, Wouter J.; Wu, Ying; Kristiansson, Kati; Demirkan, Ayse; Fornage, Myriam; Hassinen, Maija; Bielak, Lawrence F.; Cadby, Gemma; Tanaka, Toshiko; Mägi, Reedik; van der Most, Peter J.; Jackson, Anne U.; Bragg-Gresham, Jennifer L.; Vitart, Veronique; Marten, Jonathan; Navarro, Pau; Bellis, Claire; Pasko, Dorota; Johansson, Åsa; Snitker, Søren; Cheng, Yu-Ching; Eriksson, Joel; Lim, Unhee; Aadahl, Mette; Adair, Linda S.; Amin, Najaf; Balkau, Beverley; Auvinen, Juha; Beilby, John; Bergman, Richard N.; Bergmann, Sven; Bertoni, Alain G.; Blangero, John; Bonnefond, Amélie; Bonnycastle, Lori L.; Borja, Judith B.; Brage, Søren; Busonero, Fabio; Buyske, Steve; Campbell, Harry; Chines, Peter S.; Collins, Francis S.; Corre, Tanguy; Smith, George Davey; Delgado, Graciela E.; Dueker, Nicole; Dörr, Marcus; Ebeling, Tapani; Eiríksdóttir, Guðný; Esko, Tõnu; Faul, Jessica D.; Fu, Mao; Færch, Kristine; Gieger, Christian; Gläser, Sven; Gong, Jian; Gordon-Larsen, Penny; Grallert, Harald; Grammer, Tanja B.; Grarup, Niels; van Grootheest, Gerard; Harald, Kennet; Hastie, Nicholas D.; Havulinna, Aki S.; Hernandez, Dena; Hindorff, Lucia; Hocking, Lynne J.; Holmen, Oddgeir L.; Holzapfel, Christina; Hottenga, Jouke Jan; Huang, Jie; Huang, Tao; Hui, Jennie; Huth, Cornelia; Hutri-Kähönen, Nina; James, Alan L.; Jansson, John-Olov; Jhun, Min A.; Juonala, Markus; Kinnunen, Leena; Koistinen, Heikki A.; Kolcic, Ivana; Komulainen, Pirjo; Kuusisto, Johanna; Kvaløy, Kirsti; Kähönen, Mika; Lakka, Timo; Launer, Lenore J.; Lehne, Benjamin; Lindgren, Cecilia M.; Lorentzon, Mattias; Luben, Robert; Marre, Michel; Milaneschi, Yuri; Monda, Keri L.; Montgomery, Grant W.; De Moor, Marleen H. M.; Mulas, Antonella; Müller-Nurasyid, Martina; Musk, A.W.; Männikkö, Reija; Männistö, Satu; Narisu, Narisu; Nauck, Matthias; Nettleton, Jennifer A.; Nolte, Ilja M.; Oldehinkel, Albertine J.; Olden, Matthias; Ong, Ken K.; Padmanabhan, Sandosh; Paternoster, Lavinia; Perez, Jeremiah; Perola, Markus; Peters, Annette; Peters, Ulrike; Peyser, Patricia A.; Prokopenko, Inga; Puolijoki, Hannu; Raitakari, Olli T.; Rankinen, Tuomo; Rasmussen-Torvik, Laura J.; Rawal, Rajesh; Ridker, Paul M.; Rose, Lynda M.; Rudan, Igor; Sarti, Cinzia; Sarzynski, Mark A.; Savonen, Kai; Scott, William R.; Sanna, Serena; Shuldiner, Alan R.; Sidney, Steve; Silbernagel, Günther; Smith, Blair H.; Smith, Jennifer A.; Snieder, Harold; Stančáková, Alena; Sternfeld, Barbara; Swift, Amy J.; Tammelin, Tuija; Tan, Sian-Tsung; Thorand, Barbara; Thuillier, Dorothée; Vandenput, Liesbeth; Vestergaard, Henrik; van Vliet-Ostaptchouk, Jana V.; Vohl, Marie-Claude; Völker, Uwe; Waeber, Gérard; Walker, Mark; Wild, Sarah; Wong, Andrew; Wright, Alan F.; Zillikens, M. Carola; Zubair, Niha; Haiman, Christopher A.; Lemarchand, Loic; Gyllensten, Ulf; Ohlsson, Claes; Hofman, Albert; Rivadeneira, Fernando; Uitterlinden, André G.; Pérusse, Louis; Wilson, James F.; Hayward, Caroline; Polasek, Ozren; Cucca, Francesco; Hveem, Kristian; Hartman, Catharina A.; Tönjes, Anke; Bandinelli, Stefania; Palmer, Lyle J.; Kardia, Sharon L. R.; Rauramaa, Rainer; Sørensen, Thorkild I. A.; Tuomilehto, Jaakko; Salomaa, Veikko; Penninx, Brenda W. J. H.; de Geus, Eco J. C.; Boomsma, Dorret I.; Lehtimäki, Terho; Mangino, Massimo; Laakso, Markku; Bouchard, Claude; Martin, Nicholas G.; Kuh, Diana; Liu, Yongmei; Linneberg, Allan; März, Winfried; Strauch, Konstantin; Kivimäki, Mika; Harris, Tamara B.; Gudnason, Vilmundur; Völzke, Henry; Qi, Lu; Järvelin, Marjo-Riitta; Chambers, John C.; Kooner, Jaspal S.; Froguel, Philippe; Kooperberg, Charles; Vollenweider, Peter; Hallmans, Göran; Hansen, Torben; Pedersen, Oluf; Metspalu, Andres; Wareham, Nicholas J.; Langenberg, Claudia; Weir, David R.; Porteous, David J.; Boerwinkle, Eric; Chasman, Daniel I.; Abecasis, Gonçalo R.; Barroso, Inês; McCarthy, Mark I.; Frayling, Timothy M.; O’Connell, Jeffrey R.; van Duijn, Cornelia M.; Boehnke, Michael; Heid, Iris M.; Mohlke, Karen L.; Strachan, David P.; Fox, Caroline S.; Liu, Ching-Ti; Hirschhorn, Joel N.; Klein, Robert J.; Johnson, Andrew D.; Borecki, Ingrid B.; Franks, Paul W.; North, Kari E.; Cupples, L. Adrienne; Loos, Ruth J. F.; Kilpeläinen, Tuomas O. (Public Library of Science (PLoS), 2017-04-27)
    Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference ...
  • Icon
    GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes 
    Smith, Albert Vernon; Gudnason, Vilmundur; Grétarsdóttir, Sólveig; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Stefansson, Kari (Springer Science and Business Media LLC, 2018-12)
    Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in ...
  • Icon
    Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma 
    Gudbjartsson, Daniel; Thorsteinsdottir, Unnur (Springer Science and Business Media LLC, 2018-09-13)
    Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, ...
  • Icon
    Large meta-analysis of genome-wide association studies identifies five loci for lean body mass 
    Zillikens, M. Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M.; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory; Broer, Linda; Johnson, Toby; Koller, Daniel L.; Kutalik, Zoltán; Luan, Jian’an; Malkin, Ida; Ried, Janina S.; Smith, Albert Vernon; Þorleifsson, Guðmar; Vandenput, Liesbeth; Hua Zhao, Jing; Zhang, Weihua; Aghdassi, Ali; Åkesson, Kristina; Amin, Najaf; Baier, Leslie J.; Barroso, Inês; Bennett, David A.; Bertram, Lars; Biffar, Reiner; Bochud, Murielle; Boehnke, Michael; Borecki, Ingrid; Buchman, Aron S.; Byberg, Liisa; Campbell, Harry; Campos Obanda, Natalia; Cauley, Jane A.; Cawthon, Peggy M.; Cederberg, Henna; Chen, Zhao; Cho, Nam H.; Jin Choi, Hyung; Claussnitzer, Melina; Collins, Francis; Cummings, Steven R.; De Jager, Philip L.; Demuth, Ilja; Dhonukshe-Rutten, Rosalie A. M.; Diatchenko, Luda; Eiríksdóttir, Guðný; Enneman, Anke W.; Erdos, Mike; Eriksson, Johan G.; Eriksson, Joel; Estrada, Karol; Evans, Daniel S.; Feitosa, Mary F.; Fu, Mao; Garcia, Melissa; Gieger, Christian; Girke, Thomas; Glazer, Nicole L.; Grallert, Harald; Grewal, Jagvir; Han, Bok-Ghee; Hanson, Robert L.; Hayward, Caroline; Hofman, Albert; Hoffman, Eric P.; Homuth, Georg; Hsueh, Wen-Chi; Hubal, Monica J.; Hubbard, Alan; Huffman, Kim M.; Husted, Lise B.; Illig, Thomas; Ingelsson, Erik; Ittermann, Till; Jansson, John-Olov; Jordan, Joanne M.; Jula, Antti; Karlsson, Magnus; Khaw, Kay-Tee; Kilpeläinen, Tuomas O.; Klopp, Norman; Kloth, Jacqueline S. L.; Koistinen, Heikki A.; Kraus, William E.; Kritchevsky, Stephen; Kuulasmaa, Teemu; Kuusisto, Johanna; Laakso, Markku; Lahti, Jari; Lang, Thomas; Langdahl, Bente L.; Launer, Lenore J.; Lee, Jong-Young; Lerch, Markus M.; Lewis, Joshua R.; Lind, Lars; Lindgren, Cecilia; Liu, Yongmei; Liu, Tian; Liu, Youfang; Ljunggren, Östen; Lorentzon, Mattias; Luben, Robert; Maixner, William; McGuigan, Fiona E.; Medina-Gomez, Carolina; Meitinger, Thomas; Melhus, Håkan; Mellström, Dan; Melov, Simon; Michaëlsson, Karl; Mitchell, Braxton D.; Morris, Andrew P.; Mosekilde, Leif; Newman, Anne; Nielson, Carrie M.; O’Connell, Jeffrey R.; Oostra, Ben A.; Orwoll, Eric S.; Palotie, Aarno; Parker, Stephan; Peacock, Munro; Perola, Markus; Peters, Annette; Polasek, Ozren; Prince, Richard L.; Räikkönen, Katri; Ralston, Stuart H.; Ripatti, Samuli; Robbins, John A.; Rotter, Jerome I.; Rudan, Igor; Salomaa, Veikko; Satterfield, Suzanne; Schadt, Eric E.; Schipf, Sabine; Scott, Laura; Sehmi, Joban; Shen, Jian; Soo Shin, Chan; Sigurdsson, Gunnar; Smith, Shad; Soranzo, Nicole; Stančáková, Alena; Steinhagen-Thiessen, Elisabeth; Streeten, Elizabeth A.; Styrkarsdottir, Unnur; Swart, Karin M. A.; Tan, Sian-Tsung; Tarnopolsky, Mark A.; Thompson, Patricia; Thomson, Cynthia A.; Thorsteinsdottir, Unnur; Tikkanen, Emmi; Tranah, Gregory J.; Tuomilehto, Jaakko; van Schoor, Natasja M.; Verma, Arjun; Vollenweider, Peter; Völzke, Henry; Wactawski-Wende, Jean; Walker, Mark; Weedon, Michael N.; Welch, Ryan; Wichmann, H.-Erich; Widen, Elisabeth; Williams, Frances M. K.; Wilson, James F.; Wright, Nicole C.; Xie, Weijia; Yu, Lei; Zhou, Yanhua; Chambers, John C.; Döring, Angela; van Duijn, Cornelia M.; Econs, Michael J.; Gudnason, Vilmundur; Kooner, Jaspal S.; Psaty, Bruce M.; Spector, Timothy D.; Stefansson, Kari; Rivadeneira, Fernando; Uitterlinden, André G.; Wareham, Nicholas J.; Ossowski, Vicky; Waterworth, Dawn; Loos, Ruth J. F.; Karasik, David; Harris, Tamara B.; Ohlsson, Claes; Kiel, Douglas P. (Springer Nature, 2017-07-19)
    Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) ...
  • Icon
    Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria 
    Day, Felix; Karaderi, Tugce; Jones, Michelle R.; Meun, Cindy; He, Chunyan; Drong, Alex; Kraft, Peter; Lin, Nan; Huang, Hongyan; Broer, Linda; Magi, Reedik; Saxena, Richa; Laisk, Triin; Urbanek, Margrit; Hayes, M. Geoffrey; Thorleifsson, Gudmar; Fernandez-Tajes, Juan; Mahajan, Anubha; Mullin, Benjamin H.; Stuckey, Bronwyn G. A.; Spector, Timothy D.; Wilson, Scott G.; Goodarzi, Mark O.; Davis, Lea; Obermayer-Pietsch, Barbara; Uitterlinden, André G.; Anttila, Verneri; Neale, Benjamin M.; Jarvelin, Marjo-Riitta; Fauser, Bart; Kowalska, Irina; Visser, Jenny A.; Andersen, Marianne; Ong, Ken; Stener-Victorin, Elisabet; Ehrmann, David; Legro, Richard S.; Salumets, Andres; McCarthy, Mark I.; Morin-Papunen, Laure; Thorsteinsdottir, Unnur; Stefansson, Kari; Styrkarsdottir, Unnur; Perry, John R. B.; Dunaif, Andrea; Laven, Joop; Franks, Steve; Lindgren, Cecilia M.; Welt, Corrine K. (Public Library of Science (PLoS), 2018-12-19)
    Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose ...