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Browsing by Subject "Geðklofi"

Browsing by Subject "Geðklofi"

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  • Ingimarsson, Oddur (University of Iceland, School of Health Sciences, Faculty of Medicine, 2018-04-10)
    Background: Schizophrenia is a chronic serious mental disorder with prevalence close to 0.7%. Early symptoms of schizophrenia generally appear in late adolescence or the early twenties. The prognosis is usually worse in cases of early onset. The ...
  • Sigurdsson, Engilbert (Springer Science and Business Media LLC, 2018-07-05)
    Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association ...
  • Vidarsdottir, Olina (University of Iceland, school of health sciences, faculty of medicine, 2020-09)
    Background: Cognitive impairment is a core feature at all stages of the psychotic illness and significantly predicts functional outcomes. Targeting cognition early is theoretically attractive as a means to reverse the functional impairment before ...
  • Andlauer, Till F. M.; Sigurdsson, Engilbert; Stefansson, Kari (Springer Science and Business Media LLC, 2019-11-11)
    Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is ...
  • Sønderby, Ida E; Ulfarsson, Magnus; Walters, G. Bragi; Stefansson, Kari (Springer Science and Business Media LLC, 2018-10-03)
    Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes ...
  • Friðþjófsdóttir, Helga Guðrún; Geirsdottir, Olof; Jónsdóttir, Halldóra; Steingrimsdottir, Laufey; Thorsdottir , Inga; Þorgeirsdóttir, Hólmfríður; Briem, Nanna; Gunnarsdottir, Ingibjorg (Læknafélag Íslands / Icelandic Medical Association, 2017-06-06)
    Tilgangur: Tíðni lífsstílssjúkdóma er hærri meðal einstaklinga með geð- rofssjúkdóma en almennings. Tilgangur rannsóknarinnar var að kanna fæðuval ungs fólks með geðrofssjúkdóma, en fæðuval þessa hóps hefur aldrei verið kannað hérlendis áður. Efniviður ...
  • Ingimarsson, Oddur; MacCabe, James; Haraldsson, Magnús; Jónsdóttir, Halldóra; Sigurdsson, Engilbert (Springer Nature, 2016-12)
    Background Data on the haematological outcomes of patients who continue clozapine treatment following neutropenia are very rare as even mild neutropenia results in mandatory discontinuation of clozapine in most countries. However, in Iceland where ...
  • Hess, Jonathan L.; Sigurdsson, Engilbert; Stefansson, Hreinn; Stefansson, Kari (Springer Science and Business Media LLC, 2019-09-06)
    Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531–538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited the existence of genetic variants ...
  • Reginsson, Gunnar W.; Ingason, Andrés; Euesden, Jack; Bjornsdottir, Gyda; Ólafsson, Sigurgeir; Sigurdsson, Engilbert; Óskarsson, Högni; Tyrfingsson, Þórarinn; Rúnarsdóttir, Valgerður; Hansdóttir, Ingunn; Steinberg, Stacy; Stefánsson, Hreinn; Gudbjartsson, Daniel; Thorgeirsson, Thorgeir; Stefansson, Kari (Wiley, 2017-02-23)
    We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 ...
  • Lu, Donghao; Song, Jie; Lu, Yi; Fall, Katja; Chen, Xu; Fang, Fang; Landén, Mikael; Hultman, Christina M.; Czene, Kamila; Sullivan, Patrick; Tamimi, Rulla M.; Valdimarsdottir, Unnur (Springer Science and Business Media LLC, 2020-09-15)
    An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic ...
  • Marcu, Sara; Pegolo, Elena; Ívarsson, Eysteinn; Jónasson, Aron Dalin; Jónasson, Viktor; Aubonnet, Romain; Gargiulo, Paolo; Banea, Ovidiu Constantin (PAGEPress Publications, 2020-04-01)
    We present preliminary results from the ongoing study entitled "Icelandic AVH-TMS" which aim is to study the effectiveness of repetitive transcranial magnetic stimulation (rTMS) treatment for patients with schizophrenia and with persistent auditory ...