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Browsing by Subject "Erfðabreytileiki"

Browsing by Subject "Erfðabreytileiki"

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    Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations 
    Daya, Michelle; Bjarnadóttir, Hrafnhildur (Springer Science and Business Media LLC, 2019-02-20)
    Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true ...
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    Dissecting the regulatory role for a MUC5B polymorphism involved in Idiopathic Pulmonary Fibrosis 
    Armesto Jimenez, Amaranta (University of Iceland, School of Health Sciences, Faculty of Medicine, 2018-08-17)
    Idiopathic pulmonary fibrosis is a severe lung disease with unknown aetiology. The lifespan is approximately 3 to 5 years after diagnosis, and the treatments available such as lung transplant are high risk and are not suitable for all patients. In ...
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    Extensive genetic differentiation between recently evolved sympatric Arctic charr morphs 
    Guðbrandsson, Jóhannes; Kapralova, Kalina; Franzdottir, Sigridur Rut; Bergsveinsdóttir, Þóra Margrét; Hafstað, Völundur; Jónsson, Zophonías Oddur; Snorrason, Sigurður S.; Palsson, Arnar (Wiley, 2019-09-12)
    The availability of diverse ecological niches can promote adaptation of trophic specializations and related traits, as has been repeatedly observed in evolutionary radiations of freshwater fish. The role of genetics, environment, and history in ...
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    Gene expression during early development and genetic variation among recently evolved sympatric Arctic charr (Salvelinus alpinus) morphs in Lake Þingvallavatn, Iceland 
    Guðbrandsson, Jóhannes (University of Iceland, School of Engineering and Natural Sciences, Faculty of Life and Environmental Sciences, 2019-04-26)
    The four morphs of Arctic charr (Salvelinus alpinus) in Lake Þingvallavatn, Iceland, which differ in many phenotypic traits related to morphology, life history, and feeding ecology, are believed to have evolved locally within the lake after the retreat ...
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    Genetic parameters for Icelandic dairy cows using a random regression test-day model 
    Eiríksson, Jón Hjalti; Sigurdsson, Agust; Jóhannesson, Guðmundur; Eythorsdottir, Emma (Agricultural University of Iceland, 2019)
    A total of 480,495 test-day yield records of 33,052 cows were used to estimate the genetic parameters for daily milk yield (MY), fat yield (FY), protein yield (PY) and somatic cell score (SCS) of Icelandic dairy cows in the first three lactations with ...
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    High genetic diversity ofVibrio choleraein the European lake Neusiedler See is associated with intensive recombination in the reed habitat and the long-distance transfer of strains 
    Pretzer, Carina; Druzhinina, Irina S.; Amaro, Carmen; Benediktsdóttir, Eva; Hedenström, Ingela; Hervio-Heath, Dominique; Huhulescu, Steliana; Schets, Franciska M.; Farnleitner, Andreas H.; Kirschner, Alexander K. T. (Wiley-Blackwell, 2017-01)
    Coastal marine Vibrio cholerae populations usually exhibit high genetic diversity. To assess the genetic diversity of abundant V. cholerae non-O1/non-O139 populations in the Central European lake Neusiedler See, we performed a phylogenetic analysis ...
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    Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism 
    Sapkota, Yadav; Steinthorsdottir, Valgerdur; Morris, Andrew P.; Fassbender, Amelie; Rahmioglu, Nilufer; De Vivo, Immaculata; Buring, Julie E.; Zhang, Futao; Edwards, Todd L.; Jones, Sarah; O, Dorien; Peterse, Daniëlle; Rexrode, Kathryn M.; Ridker, Paul M.; Schork, Andrew J.; MacGregor, Stuart; Martin, Nicholas G.; Becker, Christian M.; Adachi, Sosuke; Yoshihara, Kosuke; Enomoto, Takayuki; Takahashi, Atsushi; Kamatani, Yoichiro; Matsuda, Koichi; Kubo, Michiaki; Þorleifsson, Guðmar; Geirsson, Reynir T.; Thorsteinsdottir, Unnur; Wallace, Leanne M.; Werge, Thomas M.; Thompson, Wesley K.; Yang, Jian; Velez Edwards, Digna R.; Nyegaard, Mette; Low, Siew-Kee; Zondervan, Krina T.; Missmer, Stacey A.; D'Hooghe, Thomas; Montgomery, Grant W.; Chasman, Daniel I.; Stefansson, Kari; Tung, Joyce Y.; Nyholt, Dale R. (Springer Nature, 2017-05-24)
    Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association ...
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    Sequence variants associating with urinary biomarkers 
    Benonisdottir, Stefania; Kristjansson, Ragnar P; Oddsson, Asmundur; Steinthorsdottir, Valgerdur; Mikaelsdottir, Evgenia; Kehr, Birte; Jensson, Brynjar O; Arnadottir, Gudny A; Sulem, Gerald; Sveinbjornsson, Gardar; Kristmundsdóttir, Snædís; Ívarsdóttir, Erna V.; Tragante, Vinicius; Gunnarsson, Bjarni; Runolfsdottir, Hrafnhildur Linnet; Arthur, Joseph G; Deaton, Aimee M; Eyjolfsson, Gudmundur I; Davidsson, Olafur B; Asselbergs, Folkert W; Hreidarsson, Astradur B; Rafnar, Thorunn; Thorleifsson, Gudmar; Edvardsson, Vidar; Sigurdsson, Gunnar; Helgadottir, Anna; Halldórsson, Bjarni; Masson, Gisli; Holm, Hilma; Önundarson, Páll Torfi; Indridason, Olafur S; Benediktsson, Rafn; Palsson, Runolfur; Gudbjartsson, Daniel F; Olafsson, Isleifur; Thorsteinsdottir, Unnur; sulem, patrick; Stefansson, Kari (Oxford University Press (OUP), 2018-11-24)
    Urine dipstick tests are widely used in routine medical care to diagnose kidney and urinary tract and metabolic diseases. Several environmental factors are known to affect the test results, whereas the effects of genetic diversity are largely unknown. ...
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    Using whole-genome sequence data to discover causes of unexplained rare diseases and miscarriage 
    Árnadóttir, Guðný Anna (University of Iceland, School of Health Sciences, Faculty of Medicine, 2024-04-14)
    Introduction and aims: Although individually, Mendelian disorders are considered rare, collectively they make up a large group of individuals requiring diagnosis and treatment. Because of their individual rarity, many of these disorders are understudied ...
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    Whole genome characterization of sequence diversity of 15,220 Icelanders 
    Jónsson, Hákon; sulem, patrick; Kehr, Birte; Kristmundsdóttir, Snædís; Zink, Florian; Hjartarson, Eiríkur; Hardarson, Marteinn; Hjorleifsson, Kristjan; Eggertsson, Hannes; Guðjónsson, Sigurjón Axel; Ward, Lucas D.; Arnadottir, Gudny; Helgason, Einar A.; Helgason, Hannes; Gylfason, Arnaldur; Jónasdóttir, Aðalbjörg; Jónasdóttir, Áslaug; Rafnar, Thorunn; Besenbacher, Soren; Frigge, Michael L.; Stacey, Simon N.; Magnússon, Ólafur T.; Þorsteinsdóttir, Unnur; Másson, Gísli; Kong, Augustine; Halldórsson, Bjarni; Helgason, Agnar; Gudbjartsson, Daniel; Stefansson, Kari (Springer Nature, 2017-09-21)
    Understanding of sequence diversity is the cornerstone of analysis of genetic disorders, population genetics, and evolutionary biology. Here, we present an update of our sequencing set to 15,220 Icelanders who we sequenced to an average genome-wide ...