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Fletta eftir efnisorði "Efnaskipti"
Atriði 1-20 af 23
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(2022-02-24)Metabolomics in human serum samples provide a snapshot of the current metabolic state of an individuum. Metabolite concentrations are influenced by both genetic and environmental factors. Concentrations of certain metabolites can further depend on age, ... -
(2022-02)Background & aims: Intake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a ...
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(Frontiers Media SA, 2018-02-27)Growth in sodium chloride (NaCl) is known to induce stress in non-halophilic microorganisms leading to effects on the microbial metabolism and cell structure. Microorganisms have evolved a number of adaptations, both structural and metabolic, to ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2023-11-16)ATG7, an essential protein for cellular homeostasis, plays a pivotal role in regulating autophagy. The autophagy process ensures the degradation and recycling of cellular components for proper cell function. ATG7 facilitates the lipidation of ATG8 ...
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(Frontiers Media SA, 2020-03-31)Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2022-05-24)Breast cancer is the leading cause of cancer deaths among women in Iceland and worldwide. Epithelial-mesenchymal transition (EMT) is a cellular developmental process where epithelial cells assume mesenchymal-like phenotypes through degradation of the ...
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(Springer Nature, 2017-04-07)The increasing availability of metabolomics data necessitates novel methods for deeper data analysis and interpretation. We present a flux balance analysis method that allows for the computation of dynamic intracellular metabolic changes at the cellular ...
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Examining the link between maternal nutrition, gestational weight gain, and later offspring health (University of Iceland, School of Health Sciences, Faculty of Food Science and Nutrition, 2018-01)Aim: The aim of this Ph.D. thesis is to enhance understanding of the relation between maternal diet, gestational weight gain (GWG), and offspring’s cardio-metabolic factors. Moreover, the objective is to identify dietary predictors for excessive GWG. ...
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(2020-06)Background De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL ...
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(Springer Science and Business Media LLC, 2020-08-07)Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to 119,715 individuals and identify ...
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(2021-09-30)Aims: To present secondary outcome analyses of liraglutide treatment in overweight adults with insulin pump-treated type 1 diabetes (T1D), focusing on changes in body composition and dimensions, and to evaluate changes in food intake to identify potential ...
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(MDPI AG, 2017-02-22)Twenty-eight sponge specimens were collected at a shallow water hydrothermal vent site north of Iceland. Extracts were prepared and tested in vitro for cytotoxic activity, and eight of them were shown to be cytotoxic. A mass spectrometry (MS)-based ...
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(Elsevier BV, 2017-06)Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
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Metabolic systems analysis of breast epithelial cells following epithelial-to-mesenchymal transition (University of Iceland, School of Health Sciences, Faculty of Medicine, 2022-02-25)Breast cancer is a heterogenous disease in which the mechanism for signalling, gene expression, metabolism and growth in breast tissue is deranged. Breast cancer is responsible for the death of over 600,000 people worldwide on a yearly basis. By ...
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(2021-09-10)Á undanförnum árum hafa sviðin endurnýjunar og tilfærslu lækningar vakið sífellt meiri áhuga vegna möguleikanna sem í þeim felast er varða nýjungar í læknavísindum. Innan þeirra má finna ýmis tól sem talin eru vera lykilatriði þegar kemur að því að ...
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(2020-12-28)Monoamine oxidase A (MAO‐A) deficiency is a rare inborn error of metabolism with impaired degradation of biogenic amines including 5‐hydroxytryptamine (5‐HT), resulting in borderline intellectual disability and behavioral abnormalities. Genetic variants ...
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(2021-07)Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. We assess the effects of nicotinamide (a precursor to ...
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(Dove Medical Press Ltd., 2018-10)Purpose: Dietary macronutrient composition, stearoyl-CoA desaturase (SCD) activity indices, and primary bile acid (BA) concentrations are among the factors that have been associated with lipid metabolism and contributed to obesity. We investigated the ...
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(2021-05-26)Living systems formed and evolved under constraints that govern their interactions with the inorganic world. These interactions are definable using basic physico-chemical principles. Here, we formulate a comprehensive set of ten governing abiotic ...
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(Springer Nature, 2017-08-15)Background There are an increasing number of studies regarding genetic manipulation of cyanobacteria to produce commercially interesting compounds. The majority of these works study the expression and optimization of a selected heterologous pathway, ...
Atriði 1-20 af 23