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Browsing by Subject "Efnaskipti"

Browsing by Subject "Efnaskipti"

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  • Schwendner, Petra; Bohmeier, Maria; Rettberg, Petra; Beblo-Vranesevic, Kristina; Gaboyer, Frédéric; Moissl-Eichinger, Christine; Perras, Alexandra K.; Vannier, Pauline; Marteinsson, Viggó; Garcia-Descalzo, Laura; Gómez, Felipe; Malki, Moustafa; Amils, Ricardo; Westall, Frances; Riedo, Andreas; Monaghan, Euan P.; Ehrenfreund, Pascale; Cabezas, Patricia; Walter, Nicolas; Cockell, Charles (Frontiers Media SA, 2018-02-27)
    Growth in sodium chloride (NaCl) is known to induce stress in non-halophilic microorganisms leading to effects on the microbial metabolism and cell structure. Microorganisms have evolved a number of adaptations, both structural and metabolic, to ...
  • Sigmarsdóttir, Þóra; McGarrity, Sarah; Rolfsson, Óttar; Yurkovich, James T.; Sigurjónsson, Ólafur E. (Frontiers Media SA, 2020-03-31)
    Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct ...
  • Bordbar, Aarash; Yurkovich, James T.; Paglia, Giuseppe; Rolfsson, Óttar; Sigurjónsson, Ólafur E.; Palsson, Bernhard O. (Springer Nature, 2017-04-07)
    The increasing availability of metabolomics data necessitates novel methods for deeper data analysis and interpretation. We present a flux balance analysis method that allows for the computation of dynamic intracellular metabolic changes at the cellular ...
  • Hrolfsdottir, Laufey (University of Iceland, School of Health Sciences, Faculty of Food Science and Nutrition, 2018-01)
    Aim: The aim of this Ph.D. thesis is to enhance understanding of the relation between maternal diet, gestational weight gain (GWG), and offspring’s cardio-metabolic factors. Moreover, the objective is to identify dietary predictors for excessive GWG. ...
  • Zhou, Wei; Brumpton, Ben; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Josh; Zawistowski, Matthew; Nielsen, Jonas B.; Chaker, Layal; Medici, Marco; Teumer, Alexander; Naitza, Silvia; Sanna, Serena; Schultheiss, Ulla T.; Cappola, Anne; Karjalainen, Juha; Kurki, Mitja; Oneka, Morgan; Taylor, Peter; Fritsche, Lars G.; Graham, Sarah E.; Wolford, Brooke N.; Overton, William; Rasheed, Humaira; Haug, Eirin B.; Gabrielsen, Maiken E.; Skogholt, Anne Heidi; Surakka, Ida; Davey Smith, George; Pandit, Anita; Roychowdhury, Tanmoy; Hornsby, Whitney E.; Jonasson, Jon G.; Senter, Leigha; Liyanarachchi, Sandya; Ringel, Matthew D.; Xu, Li; Kiemeney, Lambertus A.; He, Huiling; Netea-Maier, Romana T.; Mayordomo, Jose I.; Plantinga, Theo S.; Hrafnkelsson, Jon; Hjartarson, Hannes; Sturgis, Erich M.; Palotie, Aarno; Daly, Mark; Citterio, Cintia E.; Arvan, Peter; Brummett, Chad M.; Boehnke, Michael; de la Chapelle, Albert; Stefansson, Kari; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav (Springer Science and Business Media LLC, 2020-08-07)
    Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to 119,715 individuals and identify ...
  • Einarsdóttir, Eydís; Magnúsdóttir, Manuela; Astarita, Giuseppe; Köck, Matthias; Ögmundsdóttir, Helga M.; Þorsteinsdóttir, Margrét; Rapp, Hans; Omarsdottir, Sesselja; Paglia, Giuseppe (MDPI AG, 2017-02-22)
    Twenty-eight sponge specimens were collected at a shallow water hydrothermal vent site north of Iceland. Extracts were prepared and tested in vitro for cytotoxic activity, and eight of them were shown to be cytotoxic. A mass spectrometry (MS)-based ...
  • Halldorsson, Skarphedinn; Rohatgi, Neha; Magnúsdóttir, Manuela; Choudhary, Kumari Sonal; Gudjonsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdóttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild M.; Guðmundsson, Steinn; Rolfsson, Óttar (Elsevier BV, 2017-06)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
  • Skúladóttir, Guðrún Valgerður; Óskarsdóttir, Harpa; Pisanu, Claudia; Sjödin, Marcus; Lindberg, Johan; Mwinyi, Jessica; Schiöth, Helgi B (Dove Medical Press Ltd., 2018-10)
    Purpose: Dietary macronutrient composition, stearoyl-CoA desaturase (SCD) activity indices, and primary bile acid (BA) concentrations are among the factors that have been associated with lipid metabolism and contributed to obesity. We investigated the ...
  • Vavitsas, Konstantinos; Rue, Emil Østergaard; Stefánsdóttir, Lára Kristín; Gnanasekaran, Thiyagarajan; Blennow, Andreas; Crocoll, Christoph; Guðmundsson, Steinn; Jensen, Poul Erik (Springer Nature, 2017-08-15)
    Background There are an increasing number of studies regarding genetic manipulation of cyanobacteria to produce commercially interesting compounds. The majority of these works study the expression and optimization of a selected heterologous pathway, ...
  • Yurkovich, James; Bordbar, Aarash; Sigurjonsson, Olafur; Palsson, Bernhard O. (Springer Nature, 2018-03-07)
    Blood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of transfusion medicine has started to benefit from the “omic” data revolution and corresponding ...
  • Rohatgi, Neha (University of Iceland, School of Health Sciences, Faculty of Medicine, 2016-12)
    Studying human metabolism is crucial for the understanding of diseases and improvement of therapy as metabolic alterations are central to a number of human diseases. A variety of experimental disciplines, such as biochemistry, biophysics and systems ...
  • Buchweitz, Lea F.; Yurkovich, James T.; Blessing, Christoph; Kohler, Veronika; Schwarzkopf, Fabian; King, Zachary A.; Yang, Laurence; Jóhannsson, Freyr; Sigurjónsson, Ólafur E.; Rolfsson, Óttar; Heinrich, Julian; Dräger, Andreas (Springer Science and Business Media LLC, 2020-04-03)
    Background: New technologies have given rise to an abundance of-omics data, particularly metabolomic data. The scale of these data introduces new challenges for the interpretation and extraction of knowledge, requiring the development of innovative ...