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Browsing by Subject "DNA"

Browsing by Subject "DNA"

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    Dynamics of Nucleic Acids at Room Temperature Revealed by Pulsed EPR Spectroscopy 
    Gränz, Markus; Erlenbach, Nicole; Spindler, Philipp; Gophane, Dnyaneshwar B.; Stelzl, Lukas S.; Sigurdsson, Snorri; Prisner, Thomas F. (Wiley, 2018-08-13)
    The investigation of the structure and conformational dynamics of biomolecules under physiological conditions is challenging for structural biology. Although pulsed electron paramagnetic resonance (like PELDOR) techniques provide long‐range distance ...
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    Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs 
    Framme, Jenny Lingman; Lundqvist, Christina; Lundell, Anna Carin; van Schouwenburg, Pauline A.; Lemarquis, Andri L.; Thörn, Karolina; Lindgren, Susanne; Gudmundsdottir, Judith; Lundberg, Vanja; Degerman, Sofie; Zetterström, Rolf H.; Borte, Stephan; Hammarström, Lennart; Telemo, Esbjörn; Hultdin, Magnus; van der Burg, Mirjam; Fasth, Anders; Oskarsdóttir, Sólveig; Ekwall, Olov (2022-01-26)
    Background: Population-based neonatal screening using T-cell receptor excision circles (TRECs) identifies infants with profound T lymphopenia, as seen in cases of severe combined immunodeficiency, and in a subgroup of infants with 22q11 deletion syndrome ...
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    Noncovalent and site-directed spin labeling of duplex RNA 
    Kamble, Nilesh Ramesh; Gränz, Markus; Prisner, Thomas F.; Sigurdsson, Snorri (Royal Society of Chemistry (RSC), 2016)
    An isoindoline-nitroxide derivative of guanine (G, "G-spin") was shown to bind specifically and effectively to abasic sites in duplex RNAs. Distance measurements on a G-labeled duplex RNA with PELDOR (DEER) showed a strong orientation dependence. Thus, ...
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    Noncovalent spin-labeling of RNA: the aptamer approach 
    Saha, Subham; Hetzke, Thilo; Prisner, Thomas F.; Sigurdsson, Snorri (Royal Society of Chemistry (RSC), 2018)
    In the first example of site-directed spin-labeling of unmodified RNA, a pyrrolidine-nitroxide derivative of tetramethylrosamine (TMR) was shown to bind with high affinity to the malachite green (MG) aptamer, as determined by continuous-wave (CW) ...
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    Noncovalent Spin‐Labeling of DNA and RNA Triplexes 
    Kamble, Nilesh Ramesh; Wolfrum, Manpreet; Halbritter, Thomas; Sigurdsson, Snorri; Richert, Clemens (Wiley, 2020-01-21)
    Studying nucleic acids often requires labeling. Many labeling approaches require covalent bonds between the nucleic acid and the label, which complicates experimental procedures. Noncovalent labeling avoids the need for highly specific reagents and ...
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    Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis 
    Guðmundsdóttir, Judith Amalía; Thorgeirsdottir, Sigridur; Lundbäck, Veroniqa; Göngrich, Christina; Lingman Framme, Jenny; Kindgren, Erik; Rydenman, Karin; Lúðvíksson, Björn Rúnar; Bjarnadóttir, Helga; Runarsdottir, Saga; Nilsson, Staffan; Zetterström, Rolf H.; Ekwall, Olov; Lindgren, Susanne (2023-04)
    Objective: Dysregulated central tolerance predisposes to autoimmune diseases. Reduced thymic output as well as compromised central B cell tolerance checkpoints have been proposed in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of ...
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    Return of genomic results does not motivate intent to participate in research for all : Perspectives across 22 countries 
    Milne, Richard; Morley, Katherine I; Almarri, Mohamed A; Atutornu, Jerome; Baranova, Elena E; Bevan, Paul; Cerezo, Maria; Cong, Yali; Costa, Alessia; Feijao, Carolina; de Freitas, Cláudia; Fernow, Josepine; Goodhand, Peter; Hasan, Qurratulain; Hibino, Aiko; Houeland, Gry; Howard, Heidi C; Hussain Sheikh, Zakir; Malmgren, Charlotta Ingvoldstad; Izhevskaya, Vera L; Jędrzejak, Aleksandra; Jinhong, Cao; Kimura, Megumi; Kleiderman, Erika; Liu, Keying; Mascalzoni, Deborah; Mendes, Álvaro; Minari, Jusaku; Nicol, Dianne; Niemiec, Emilia; Patch, Christine; Prainsack, Barbara; Rivière, Marie; Robarts, Lauren; Roberts, Jonathan; Romano, Virginia; Sheerah, Haytham A; Smith, James; Soulier, Alexandra; Steed, Claire; Stefánsdóttir, Vigdís Fjóla; Tandre, Cornelia; Thorogood, Adrian; Voigt, Torsten H; Wang, Nan; Yoshizawa, Go; Middleton, Anna (2022-05)
    PURPOSE: The aim of this study was to determine how attitudes toward the return of genomic research results vary internationally. METHODS: We analyzed the "Your DNA, Your Say" online survey of public perspectives on genomic data sharing including ...
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    Screening and computational analysis of colorectal associated non-synonymous polymorphism in CTNNB1 gene in Pakistani population 
    Razak, Suhail; Bibi, Nousheen; Dar, Javid Ahmad; Afsar, Tayyaba; Almajwal, Ali; Parveen, Zahida; Jahan, Sarwat (Springer Science and Business Media LLC, 2019-11-07)
    Background: Colorectal cancer (CRC) is categorized by alteration of vital pathways such as β-catenin (CTNNB1) mutations, WNT signaling activation, tumor protein 53 (TP53) inactivation, BRAF, Adenomatous polyposis coli (APC) inactivation, KRAS, dysregulation ...