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Browsing by Subject "DNA methylation"

Browsing by Subject "DNA methylation"

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    CpG promoter hypo-methylation and up-regulation of microRNA-190b in hormone receptor-positive breast cancer 
    Frick, Elisabet; Gudjonsson, Thorkell; Eyfjörð, Jórunn Erla; Jonasson, Jon; Tryggvadóttir, Laufey; Stefansson, Olafur; Sigurdsson, Stefan (Impact Journals, LLC, 2019-07-23)
    Estrogen receptor-positive breast cancer is subdivided into subtypes LuminalA and LuminalB, based on different expression patterns. MicroRNA-190b has been reported to be up-regulated in estrogen receptor-positive breast cancers. In this study we aimed ...
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    DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis 
    Kular, Lara; Liu, Yun; Ruhrmann, Sabrina; Zheleznyakova, Galina; Marabita, Francesco; Gomez-Cabrero, David; James, Tojo; Ewing, Ewoud; Lindén, Magdalena; Górnikiewicz, Bartosz; Aeinehband, Shahin; Stridh, Pernilla; Link, Jenny; Andlauer, Till F. M.; Gasperi, Christiane; Wiendl, Heinz; Zipp, Frauke; Gold, Ralf; Tackenberg, Björn; Weber, Frank; Hemmer, Bernhard; Strauch, Konstantin; Heilmann-Heimbach, Stefanie; Rawal, Rajesh; Schminke, Ulf; Schmidt, Carsten O.; Kacprowski, Tim; Franke, Andre; Laudes, Matthias; Dilthey, Alexander T.; Celius, Elisabeth G.; Søndergaard, Helle B.; Tegnér, Jesper; Harbo, Hanne F.; Oturai, Annette B.; Sigurgeir Ólafsson; Eggertsson, Hannes; Halldórsson, Bjarni; Hjaltason, Haukur; Elías Ólafsson; Jonsdottir, Ingileif; Stefansson, Kari; Olsson, Tomas; Piehl, Fredrik; Ekström, Tomas J.; Kockum, Ingrid; Feinberg, Andrew P.; Jagodic, Maja (Springer Science and Business Media LLC, 2018-06-19)
    The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated ...
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    Fathers' preconception smoking and offspring DNA methylation 
    Kitaba, Negusse Tadesse; Knudsen, Gerd Toril Mørkve; Johannessen, Ane; Rezwan, Faisal I; Malinovschi, Andrei; Oudin, Anna; Benediktsdóttir, Bryndís; Martino, David; González, Francisco Javier Callejas; Gómez, Leopoldo Palacios; Holm, Mathias; Jõgi, Nils Oskar; Dharmage, Shyamali C; Skulstad, Svein Magne; Watkins, Sarah H; Suderman, Matthew; Gómez-Real, Francisco; Schlünssen, Vivi; Svanes, Cecilie; Holloway, John W (2023-08-31)
    Background: Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify epigenetic ...
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    Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns 
    Czamara, Darina; Sigurdsson, Engilbert; Stefansson, Kari (Springer Science and Business Media LLC, 2019-06-11)
    Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions ...
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    MicroRNA-190b in breast and ovarian cancer 
    Frick, Elísabet Alexandra (University of Iceland, School of Health Sciences, Faculty of Medicine, 2023-03-30)
    Breast cancer is the most frequently diagnosed cancer today, with approximately 2.3 million new cases for the year 2020. Regardless of gender, these diagnoses represent 11.7% of all cases. For women, breast cancer falls under roughly one-third of cancer ...