Browsing by Subject "Core genome"

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Comparative pangenomics : analysis of 12 microbial pathogen pangenomes reveals conserved global structures of genetic and functional diversity

Hyun, Jason C.; Monk, Jonathan; Pálsson, Bernhard Örn (2022-01-04)

Background: With the exponential growth of publicly available genome sequences, pangenome analyses have provided increasingly complete pictures of genetic diversity for many microbial species. However, relatively few studies have scaled beyond single ...
Genomic Analyses of >3,100 Nasopharyngeal Pneumococci Revealed Significant Differences Between Pneumococci Recovered in Four Different Geographical Regions

van Tonder, Andries J.; Bray, James E.; Jolley, Keith A.; Jansen van Rensburg, Melissa; Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Maiden, Martin; Bentley, Stephen D.; Haraldsson, Ásgeir; Erlendsdóttir, Helga; Kristinsson, Karl G.; Brueggemann, Angela B. (Frontiers Media SA, 2019-02-25)

Understanding the structure of a bacterial population is essential in order to understand bacterial evolution. Estimating the core genome (those genes common to all, or nearly all, strains of a species) is a key component of such analyses. The size and ...

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