Browsing by Subject "Complement"

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Exploratory Investigation of the Plasma Proteome Associated with the Endotheliopathy of Trauma

Krocker, Joseph D.; Lee, Kyung Hyun; Henriksen, Hanne H.; Wang, Yao Wei Willa; Schoof, Erwin M.; Karvelsson, Sigurdur T.; Rolfsson, Óttar; Johansson, P. I.; Pedroza, Claudia; Wade, Charles E. (2022-06-01)

Background: The endotheliopathy of trauma (EoT) is associated with increased mortality following injury. Herein, we describe the plasma proteome related to EoT in order to provide insight into the role of the endothelium within the systemic response ...
Peptidylarginine deiminase and deiminated proteins are detected throughout early halibut ontogeny - Complement components C3 and C4 are post-translationally deiminated in halibut (Hippoglossus hippoglossus L.)

Magnadottir, Bergljot; Bragason, Birkir; Bricknell, Ian; Bowden, Timothy; Nicholas, Anthony P.; Hristova, Mariya; Guðmundsdóttir, Sigríður; Dodds, Alister W.; Lange, Sigrun (Elsevier BV, 2019-03)

Post-translational protein deimination is mediated by peptidylarginine deiminases (PADs), which are calcium dependent enzymes conserved throughout phylogeny with physiological and pathophysiological roles. Protein deimination occurs via the conversion ...

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