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Fletta eftir efnisorði "Cell Line, Tumor"

Fletta eftir efnisorði "Cell Line, Tumor"

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    ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma 
    Mensali, Nadia; Köksal, Hakan; Joaquina, Sandy; Wernhoff, Patrik; Casey, Nicholas P.; Romecin, Paola; Panisello, Carla; Rodriguez, René; Vimeux, Lene; Juzeniene, Asta; Myhre, Marit R.; Fåne, Anne; Ramírez, Carolina Castilla; Maggadottir, Solrun Melkorka; Duru, Adil Doganay; Georgoudaki, Anna Maria; Grad, Iwona; Maturana, Andrés Daniel; Gaudernack, Gustav; Kvalheim, Gunnar; Carcaboso, Angel M.; de Alava, Enrique; Donnadieu, Emmanuel; Bruland, Øyvind S.; Menendez, Pablo; Inderberg, Else Marit; Wälchli, Sébastien (2023-06-08)
    Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable ...
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    BRN2 is a non-canonical melanoma tumor-suppressor 
    Hamm, Michael; Sohier, Pierre; Petit, Valérie; Raymond, Jérémy H.; Delmas, Véronique; Le Coz, Madeleine; Gesbert, Franck; Kenny, Colin; Aktary, Zackie; Pouteaux, Marie; Rambow, Florian; Sarasin, Alain; Charoenchon, Nisamanee; Bellacosa, Alfonso; Sanchez-del-Campo, Luis; Mosteo, Laura; Lauss, Martin; Meijer, Dies; Steingrímsson, Eiríkur; Jönsson, Göran B.; Cornell, Robert A.; Davidson, Irwin; Goding, Colin R.; Larue, Lionel (2021-06-17)
    While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling ...
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    Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer 
    Grinde, Maria T; Hilmarsdóttir, Bylgja; Tunset, Hanna Maja; Henriksen, Ida Marie; Kim, Jana; Haugen, Mads H; Rye, Morten Beck; Mælandsmo, Gunhild M; Moestue, Siver A (2019-05-14)
    INTRODUCTION: Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects ...
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    Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial-Mesenchymal Transition and Responds to Oxidative Stress 
    Wang, Qiong; Karvelsson, Sigurdur Trausti; Kotronoulas, Aristotelis; Gudjonsson, Thorarinn; Halldorsson, Skarphedinn; Rolfsson, Ottar (2022-02-01)
    Breast cancer cells that have undergone partial epithelial- mesenchymal transition (EMT) are believed to be more invasive than cells that have completed EMT. To study metabolic reprogramming in different mesenchymal states, we analyzed protein expression ...
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    O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes 
    Barkovskaya, Anna; Seip, Kotryna; Hilmarsdóttir, Bylgja; Maelandsmo, Gunhild M; Moestue, Siver A; Itkonen, Harri M (2019-04-05)
    Post-translational modification of intracellular proteins with a single N-acetylglucosamine sugar (O-GlcNAcylation) regulates signaling, proliferation, metabolism and protein stability. In breast cancer, expression of the enzyme that catalyzes ...
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    UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines 
    Wang, Qiong; Karvelsson, Sigurdur Trausti; Johannsson, Freyr; Vilhjalmsson, Arnar Ingi; Hagen, Lars; de Miranda Fonseca, Davi; Sharma, Animesh; Slupphaug, Geir; Rolfsson, Ottar (2022-05)
    Metabolic rewiring is one of the indispensable drivers of epithelial–mesenchymal transition (EMT) involved in breast cancer metastasis. In this study, we explored the metabolic changes during spontaneous EMT in three separately established breast EMT ...