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Browsing by Subject "Brjóstakrabbamein"

Browsing by Subject "Brjóstakrabbamein"

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  • Arason, Adalgeir; Agnarsson, Bjarni A.; Jóhannesdóttir, Gudrún; Jóhannsson, Óskar Þór; Hilmarsdóttir, Bylgja; Reynisdóttir, Inga; Barkardottir, Rosa Bjork (MDPI AG, 2019-11-01)
    Mutations in BRCA1 result in predisposal to breast and ovarian cancers, but many variants exist with unknown clinical significance (VUS). One is BRCA1 c.4096+3A>G, which affects production of the full-length BRCA1 transcript, while augmenting transcripts ...
  • Þorvaldsdóttir, Birna (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-11)
    Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is involved in maintaining genomic stability through its roles in DNA double strand break repair and protection of stalled replication forks. The BRCA2 gene ...
  • Ísberg, Ólöf Gerður; Kim, Jiyoung; Fridriksdottir, Agla; Morsing, Mikkel; Timmermans-Wielenga, Vera; Rønnov-Jessen, Lone; Petersen, Ole W.; Villadsen, René (Springer Science and Business Media LLC, 2019-10-16)
    Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protocol ...
  • Smid, Marcel; Wilting, Saskia M.; Uhr, Katharina; Rodríguez-González, F. Germán; de Weerd, Vanja; Prager-Van der Smissen, Wendy J.C.; van der Vlugt-Daane, Michelle; van Galen, Anne; Nik-Zainal, Serena; Butler, Adam; Martin, Sancha; Davies, Helen R.; Staaf, Johan; van de Vijver, Marc J.; Richardson, Andrea L.; MacGrogan, Gaëten; Salgado, Roberto; van den Eynden, Gert G.G.M.; Purdie, Colin A.; Thompson, Alastair M.; Caldas, Carlos; Span, Paul N.; Sweep, Fred C.G.J.; Simpson, Peter T.; Lakhani, Sunil R.; Van Laere, Steven; Desmedt, Christine; Paradiso, Angelo; Eyfjörð, Jórunn Erla; Broeks, Annegien; Vincent-Salomon, Anne; Futreal, Andrew P.; Knappskog, Stian; King, Tari; Viari, Alain; Børresen-Dale, Anne-Lise; Stunnenberg, Hendrik G.; Stratton, Mike; Foekens, John A.; Sieuwerts, Anieta M.; Martens, John W.M. (Cold Spring Harbor Laboratory, 2019-01-28)
    Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs that does not rely on unmapped ...
  • Frick, Elisabet; Gudjonsson, Thorkell; Eyfjörð, Jórunn Erla; Jonasson, Jon; Tryggvadóttir, Laufey; Stefansson, Olafur; Sigurdsson, Stefan (Impact Journals, LLC, 2019-07-23)
    Estrogen receptor-positive breast cancer is subdivided into subtypes LuminalA and LuminalB, based on different expression patterns. MicroRNA-190b has been reported to be up-regulated in estrogen receptor-positive breast cancers. In this study we aimed ...
  • Stefansson, Olafur; Hermanowicz, Stefan; van der Horst, Jasper; Hilmarsdóttir, Hólmfríður; Staszczak, Zuzanna; Jónasson, Jón Gunnlaugur; Tryggvadottir, Laufey; Guðjónsson, Þorkell; Sigurðsson, Stefán (Springer Nature, 2017-07-05)
    Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E. coli AlkB homologs ...
  • Morera, Erika (University of Iceland, School of Health Sciences, Faculty of Medicine, 2020-12-02)
    Epithelial to mesenchymal transition (EMT) is a developmental trait that is hijacked in some disease conditions such as fibrosis and cancer. In cancer, EMT has been linked to increased invasion and metastasis, and is generally associated with a poor ...
  • Haraldsdottir, Alfheidur; Torfadottir, Johanna; Valdimarsdottir, Unnur; Adami, Hans-Olov; Aspelund, Thor; Tryggvadottir, Laufey; Þórðardóttir, Maríanna; Birgisdottir, Bryndis Eva; Harris, Tamara B.; Launer, Lenore J.; Gudnason, Vilmundur; Steingrimsdottir, Laufey (Public Library of Science (PLoS), 2018-05-30)
    Recent studies indicate that lifestyle factors in early life affect breast cancer risk. We therefore explored the association of high consumption of meat, milk, and whole grain products in adolescence and midlife, on breast cancer risk. We used data ...
  • Pandya, Abhilash D.; Øverbye, Anders; Sahariah, Priyanka; Gaware, Vivek S.; Høgset, Håkon; Másson, Már; Høgset, Anders; Mælandsmo, Gunhild M.; Skotland, Tore; Sandvig, Kirsten; Iversen, Tore-Geir (American Chemical Society (ACS), 2020-02-24)
    In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with different amounts of the photosensitizer ...
  • Stefánsdóttir, Vigdís (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-09)
    The overall aim of this PhD thesis was to cohesively assess the availability and use of electronic genealogy databases and information from cancer registries to construct electronically generated pedigrees for risk assessment in genetic counselling. ...
  • Piqué, Laia; Martinez de Paz, Alexia; Piñeyro, David; Martínez-Cardús, Anna; Castro de Moura, Manuel; Llinàs-Arias, Pere; Setien, Fernando; Gomez-Miragaya, Jorge; Gonzalez-Suarez, Eva; Sigurdsson, Stefan; Jónasson, Jón G.; Villanueva, Alberto; Vidal, August; Davalos, Veronica; Esteller, Manel (Springer Science and Business Media LLC, 2019-08-13)
    Human tumors show altered patterns of protein isoforms that can be related to the dysregulation of messenger RNA alternative splicing also observed in transformed cells. Although somatic mutations in core spliceosome components and their associated ...
  • Hermanowicz, Stefan (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-05)
    The DNA damage response is crucial to maintaining the integrity of DNA and the health of a cell. Unrepaired lesions within the DNA can lead to genomic instability and potentially aid in the formation of diseases such as cancer. Some cancers possess ...
  • Budkova, Zuzana; Sigurðardóttir, Anna Karen; Briem, Eiríkur; Bergthorsson, Jon Thor; Sigurðsson, Snævar; Magnusson, Magnus Karl; Traustadottir, Gunnhildur Asta; Gudjonsson, Thorarinn; Hilmarsdóttir, Bylgja (Frontiers Media SA, 2020-06-16)
    Epithelial-to-mesenchymal transition (EMT) and its reversed process mesenchymal-to-epithelial transition (MET) play a critical role in epithelial plasticity during development and cancer progression. Among important regulators of these cellular processes ...
  • Figlioli, Gisella; Agnarsson, Bjarni A.; Barkardottir, Rosa Bjork (Springer Science and Business Media LLC, 2019-11-01)
    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has ...
  • Briem, Eiríkur (University of Iceland, School of Health Sciences, Faculty of Medicine, 2018)
    Brjóstkirtillinn er myndaður af greinóttum kirtilgöngum sem umluktir eru æðaþelsríkum bandvef. Brjóstakrabbamein á upptök í kirtilþekjufrumum í endum kirtilganga. Brjóstakrabbameinsfrumur nýta sér ferli sem kallast bandvefsumbreyting þekjuvefjar til ...
  • Budková, Zuzana (2021-04)
    A better understanding of normal organ development can give deeper insight into which genes are harnessed by aberrant cells during cancer formation and progression. In my thesis, I have investigated two seemingly different, however, related, developmental ...
  • Ferreira, Manuel A.; Arason, Adalgeir (Springer Science and Business Media LLC, 2019-04-15)
    Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and ...
  • Kristbjornsdottir, Adalbjorg (University of Iceland, School of Health Sciences, Faculty of Medicine, 2016-12)
    Background and aims: Previous studies in geothermal and volcanic areas have shown high risk of certain types of cancers. The aim was to study the association between residence in geothermal areas and the incidence and mortality of cancer in ...
  • Steinhaeuser, Sarah Sophie (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-08)
    The microenvironment is increasingly being recognized as a key player in supporting cancer progression. Therefore, investigating heterotypic interactions between cancer cells and their microenvironment is important for improving our understanding ...
  • Amirfallah, Arsalan; Arason, Adalgeir; Einarsson, Hjörleifur; Guðmundsdóttir, Eydís Þórunn; Freysteinsdóttir, Edda Sigríður; Ólafsdóttir, Kristrún Auður; Jóhannsson, Óskar Þór; Agnarsson, Bjarni A.; Barkardottir, Rosa Bjork; Reynisdottir, Inga (Public Library of Science (PLoS), 2019-08-23)
    Background: Fusion genes result from genomic structural changes, which can lead to alterations in gene expression that supports tumor development. The aim of the study was to use fusion genes as a tool to identify new breast cancer (BC) genes with a ...