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Browsing by Subject "Brjóstakrabbamein"

Browsing by Subject "Brjóstakrabbamein"

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  • Þorvaldsdóttir, Birna (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-11)
    Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is involved in maintaining genomic stability through its roles in DNA double strand break repair and protection of stalled replication forks. The BRCA2 gene ...
  • Stefansson, Olafur; Hermanowicz, Stefan; van der Horst, Jasper; Hilmarsdóttir, Hólmfríður; Staszczak, Zuzanna; Jónasson, Jón Gunnlaugur; Tryggvadottir, Laufey; Guðjónsson, Þorkell; Sigurðsson, Stefán (Springer Nature, 2017-07-05)
    Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E. coli AlkB homologs ...
  • Haraldsdottir, Alfheidur; Torfadottir, Johanna; Valdimarsdottir, Unnur; Adami, Hans-Olov; Aspelund, Thor; Tryggvadottir, Laufey; Þórðardóttir, Maríanna; Birgisdottir, Bryndis Eva; Harris, Tamara B.; Launer, Lenore J.; Gudnason, Vilmundur; Steingrimsdottir, Laufey (Public Library of Science (PLoS), 2018-05-30)
    Recent studies indicate that lifestyle factors in early life affect breast cancer risk. We therefore explored the association of high consumption of meat, milk, and whole grain products in adolescence and midlife, on breast cancer risk. We used data ...
  • Stefánsdóttir, Vigdís (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-09)
    The overall aim of this PhD thesis was to cohesively assess the availability and use of electronic genealogy databases and information from cancer registries to construct electronically generated pedigrees for risk assessment in genetic counselling. ...
  • Hermanowicz, Stefan (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-05)
    The DNA damage response is crucial to maintaining the integrity of DNA and the health of a cell. Unrepaired lesions within the DNA can lead to genomic instability and potentially aid in the formation of diseases such as cancer. Some cancers possess ...
  • Briem, Eiríkur (University of Iceland, School of Health Sciences, Faculty of Medicine, 2018)
    Brjóstkirtillinn er myndaður af greinóttum kirtilgöngum sem umluktir eru æðaþelsríkum bandvef. Brjóstakrabbamein á upptök í kirtilþekjufrumum í endum kirtilganga. Brjóstakrabbameinsfrumur nýta sér ferli sem kallast bandvefsumbreyting þekjuvefjar til ...
  • Kristbjornsdottir, Adalbjorg (University of Iceland, School of Health Sciences, Faculty of Medicine, 2016-12)
    Background and aims: Previous studies in geothermal and volcanic areas have shown high risk of certain types of cancers. The aim was to study the association between residence in geothermal areas and the incidence and mortality of cancer in ...
  • Steinhaeuser, Sarah Sophie (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-08)
    The microenvironment is increasingly being recognized as a key player in supporting cancer progression. Therefore, investigating heterotypic interactions between cancer cells and their microenvironment is important for improving our understanding ...
  • Hilmarsdóttir, Bylgja; Briem, Eiríkur; Halldórsson, Skarphéðinn; Kricker, Jennifer; Ingthorsson, Saevar; Gústafsdóttir, Sigrún; Mælandsmo, Gunhild M; Magnusson, Magnus Karl; Gudjonsson, Thorarinn (Springer Nature, 2017-05-11)
    Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as ...
  • Halldorsson, Skarphedinn; Rohatgi, Neha; Magnúsdóttir, Manuela; Choudhary, Kumari Sonal; Gudjonsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdottir, Bylgja; Perander, Maria; Mælandsmo, Gunhild M.; Guðmundsson, Steinn; Rolfsson, Óttar (Elsevier BV, 2017-06)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
  • Rafnar, Thorunn; Bjarni Gunnarsson; Ólafur A. Stefánsson; Sulem, Patrick; Ingason, Andres; Frigge, Michael L.; Lilja Stefánsdóttir; Jón K. Sigurðsson; Tragante, Vinicius; Steinthorsdottir, Valgerdur; Styrkarsdottir, Unnur; Stacey, Simon N.; Gudmundsson, Julius; Guðný Anna Árnadóttir; Oddsson, Asmundur; Zink, Florian; Gísli Halldórsson; Garðar Sveinbjörnsson; Kristjansson, Ragnar; Ólafur B. Davíðsson; Anna Þórhildur Salvarsdóttir; Ásgeir Thoroddsen; Elísabet A. Helgadottir; Katrín Kristjánsdóttir; Orri Ingþórsson; Valur Guðmundsson; Geirsson, Reynir T.; Ragnheiður Árnadottir; Gudbjartsson, Daniel F.; Masson, Gisli; Asselbergs, Folkert W.; Jón Gunnlaugur Jónasson; Karl Ólafsson; Thorsteinsdottir, Unnur; Halldorsson, Bjarni V.; Thorleifsson, Gudmar; Stefansson, Kari (Springer Science and Business Media LLC, 2018-09-07)
    Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of leiomyoma in European women (16,595 cases and 523,330 controls), uncovering 21 variants at 16 loci that associate with ...