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Browsing by Subject "Biomarkers"

Browsing by Subject "Biomarkers"

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  • Madsen, Marie T. B.; Bjerregaard, Anne A.; Furtado, Jeremy D.; Halldorsson, Thorhallur; Ström, Marin; Granström, Charlotta; Giovannucci, Edward; Olsen, Sjurdur F. (MDPI AG, 2019-03-06)
    The growing interest in potential health effects of long-chain polyunsaturated fatty acids (PUFAs) makes it important to evaluate the method used to assess the fatty acid intake in nutrition research studies. We aimed to validate the questionnaire-based ...
  • Sigurjónsdóttir, Vaka Kristín; Purington, Natasha; Chaudhuri, Abanti; Zhang, Bing M.; Fernandez-Vina, Marcelo; Pálsson, Runólfur; Kambham, Neeraja; Charu, Vivek; Piburn, Kim; Maestretti, Lynn; Shah, Anika; Gallo, Amy; Concepcion, Waldo; Grimm, Paul C. (2022-03-16)
    Antibody-mediated rejection is a common cause of early kidney allograft loss but the specifics of antibody measurement, therapies and endpoints have not been universally defined. In this retrospective study, we assessed the performance of risk ...
  • Raza, Fahad; Ivanek, Renata; Freer, Heather; Reiche, Dania; Rose, Horst; Torsteinsdóttir, Sigurbjörg; Svansson, Vilhjálmur; Björnsdóttir, Sigríður; Wagner, Bettina (Springer Science and Business Media LLC, 2020-08-10)
    Background: Culicoides hypersensitivity (CH) is induced in horses by salivary allergens of Culicoides midges. In Iceland, the causal Culicoides species for CH are not present. Previous epidemiological data indicated that Icelandic horses are more ...
  • Dowsett, Joseph; Ferkingstad, Egil; Rasmussen, Line Jee Hartmann; Thørner, Lise Wegner; Magnússon, Magnús Karl; Sugden, Karen; Þorleifsson, Guðmar; Frigge, Mike; Burgdorf, Kristoffer Sølvsten; Ostrowski, Sisse Rye; Sørensen, Erik; Erikstrup, Christian; Pedersen, Ole Birger; Hansen, Thomas Folkmann; Banasik, Karina; Brunak, Søren; Tragante, Vinicius; Lund, Sigrún Helga; Stefánsdóttir, Lilja; Gunnarson, Bjarni; Poulton, Richie; Arseneault, Louise; Caspi, Avshalom; Moffitt, Terrie E.; Gudbjartsson, Daníel Fannar; Eugen-Olsen, Jesper; Stefánsson, Hreinn; Stefánsson, Kári; Ullum, Henrik (2021-06-02)
    Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed ...
  • Sammar, Marei; Drobnjak, Tijana; Mandala, Maurizio; Gizurarson, Sveinbjörn; Huppertz, Berthold; Meiri, Hamutal (2019-07-01)
    Galectins regulate cell growth, proliferation, differentiation, apoptosis, signal transduction, mRNA splicing, and interactions with the extracellular matrix. Here we focus on the galectins in the reproductive system, particularly on a group of six ...
  • van der Lee, Sven J.; Knol, Maria J.; Chauhan, Ganesh; Satizabal, Claudia L.; Smith, Albert Vernon; Hofer, Edith; Bis, Joshua C.; Hibar, Derrek P.; Hilal, Saima; van den Akker, Erik B.; Arfanakis, Konstantinos; Bernard, Manon; Yanek, Lisa R.; Amin, Najaf; Crivello, Fabrice; Cheung, Josh W.; Harris, Tamara B.; Saba, Yasaman; Lopez, Oscar L.; Li, Shuo; van der Grond, Jeroen; Yu, Lei; Paus, Tomas; Roshchupkin, Gennady V.; Amouyel, Philippe; Jahanshad, Neda; Taylor, Kent D.; Yang, Qiong; Mathias, Rasika A.; Boehringer, Stefan; Mazoyer, Bernard; Rice, Ken; Cheng, Ching Yu; Maillard, Pauline; van Heemst, Diana; Wong, Tien Yin; Niessen, Wiro J.; Beiser, Alexa S.; Beekman, Marian; Zhao, Wanting; Nyquist, Paul A.; Chen, Christopher; Launer, Lenore J.; Psaty, Bruce M.; Ikram, M. Kamran; Vernooij, Meike W.; Schmidt, Helena; Pausova, Zdenka; Becker, Diane M.; De Jager, Philip L.; Thompson, Paul M.; van Duijn, Cornelia M.; Bennett, David A.; Slagboom, P. Eline; Schmidt, Reinhold; Longstreth, W. T.; Ikram, M. Arfan; Seshadri, Sudha; Debette, Stéphanie; Gudnason, Vilmundur; Adams, Hieab H. H.; DeCarli, Charles (Springer Science and Business Media LLC, 2019-08-02)
    Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We ...
  • Kjellman, Sofia E.; Schomacker, Anders; Thomas, Elizabeth K.; Håkansson, Lena; Duboscq, Sandrine; Cluett, Allison A.; Farnsworth, Wesley; Allaart, Lis; Cowling, Owen C.; McKay, Nicholas P.; Brynjólfsson, Skafti; Ingolfsson, Olafur (Elsevier BV, 2020-07-15)
    Arctic precipitation is predicted to increase in the coming century, due to a combination of enhanced northward atmospheric moisture transport and local surface evaporation from ice-free seas. However, large model uncertainties, limited long-term ...
  • Czamara, Darina; Sigurdsson, Engilbert; Stefansson, Kari (Springer Science and Business Media LLC, 2019-06-11)
    Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions ...
  • Leifsdóttir, Kristín (University of Iceland, School of Health Sciences, Faculty of Medicine, 2022-06)
    Bakgrunnur Ágrip Börn sem verða fyrir súrefnisskorti í fæðingu og börn sem fæðast fyrir fulla meðgöngu eiga á hættu að lifa ekki af eða hljóta varanlegan heilaskaða. Hættan á þessum fylgikvillum hefur ekki minnkað á síðustu áratugum þrátt fyrir miklar ...
  • Oskarsdottir, Thora; Sigurðsson, Martin Ingi; Pálsson, Runólfur; Eythorsson, E. (2022-07-29)
    Objectives: All SARS-CoV-2-positive persons in Iceland were prospectively monitored and those who required outpatient evaluation or were admitted to hospital underwent protocolized evaluation that included a standardized panel of biomarkers. The aim ...
  • García-Descalzo, Laura; Parro, Victorino; García-Villadangos, Miriam; Cockell, Charles S.; Moissl-Eichinger, Christine; Perras, Alex; Rettberg, Petra; Beblo-Vranesevic, Kristina; Bohmeier, Maria; Rabbow, Elke; Westall, Frances; Gaboyer, Frederik; Amils, Ricardo; Malki, Moustafa; Marteinsson, Viggó; Vannier, Pauline; Ehrenfreund, Pascale; Monaghan, Euan; Riedo, Andreas; Cabezas, Patricia; Walter, Nicolas; Gómez, Felipe Gómez (MDPI AG, 2019-09-18)
    One of the main objectives for astrobiology is to unravel and explore the habitability of environments beyond Earth, paying special attention to Mars. If the combined environmental stress factors on Mars are compatible with life or if they were less ...
  • Peolsson, Anneli; Karlsson, Anette; Ghafouri, Bijar; Ebbers, Tino; Engström, Maria; Jönsson, Margaretha; Wåhlén, Karin; Romu, Thobias; Borga, Magnus; Kristjansson, Eythor; Sarig Bahat, Hilla; German, Dmitry; Zsigmond, Peter; Peterson, Gunnel (Springer Science and Business Media LLC, 2019-02-02)
    Background: There is insufficient knowledge of pathophysiological parameters to understand the mechanism behind prolonged whiplash associated disorders (WAD), and it is not known whether or not changes can be restored by rehabilitation. The aims of the ...
  • Drobnjak, Tijana; Jónsdóttir, Anna Margrét; Helgadottir, Helga; Runólfsdóttir, Margrét Soffía; Meiri, Hamutal; Sammar, Marei; Osol, George J.; Mandalà, Maurizio; Huppertz, Berthold; Gizurarson, Sveinbjorn (Informa UK Limited, 2019-03-27)
    Introduction: Reduced concentrations of placental protein 13 (PP13) during the first trimester of human pregnancy are associated with elevated risk for the subsequent development of preeclampsia, which is one of the deadliest obstetrical complications ...
  • Olsen, Sjurdur F.; Halldorsson, Thorhallur; Thorne-Lyman, A.L.; Strøm, M.; Gørtz, S.; Granstrøm, C.; Nielsen, P.H.; Wohlfahrt, J.; Lykke, J.A.; Langhoff-Roos, J.; Cohen, A.S.; Furtado, J.D.; Giovannucci, E.L.; Zhou, W. (Elsevier BV, 2018-09)
    Background: Fish oil supplementation has been shown to delay spontaneous delivery, but the levels and clinical significance remain uncertain. We examined the association between plasma fatty acids quantified in pregnancy and subsequent risk of early ...
  • Fucic, Aleksandra; Galea, Karen; Duca, Radu; El Yamani, Mounia; Frery, Nadine; Godderis, Lode; Halldorsson, Thorhallur; Iavicoli, Ivo; Ndaw, Sophie; Ribeiro, Edna; Viegas, Susana; Moshammer, Hanns (MDPI AG, 2018-06-11)
    Endocrine disruptors (EDs) belong to large and diverse groups of agents that may cause multiple biological effects associated with, for example, hormone imbalance and infertility, chronic diseases such as diabetes, genome damage and cancer. The health ...
  • Eiriksdottir, Thjodbjorg; Ardal, Steinthor; Jonsson, Benedikt A.; Lund, Sigrun H.; Ivarsdottir, Erna V.; Norland, Kristjan; Ferkingstad, Egil; Stefansson, Hreinn; Jónsdóttir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Þorgeirsson, Guðmundur; Gudbjartsson, Daniel F.; Sulem, Patrick; Thorsteinsdottir, Unnur; Stefansson, Kari; Úlfarsson, Magnús Örn (2021-06-18)
    Predicting all-cause mortality risk is challenging and requires extensive medical data. Recently, large-scale proteomics datasets have proven useful for predicting health-related outcomes. Here, we use measurements of levels of 4,684 plasma proteins ...
  • Benonisdottir, Stefania; Kristjansson, Ragnar P; Oddsson, Asmundur; Steinthorsdottir, Valgerdur; Mikaelsdottir, Evgenia; Kehr, Birte; Jensson, Brynjar O; Arnadottir, Gudny A; Sulem, Gerald; Sveinbjornsson, Gardar; Kristmundsdóttir, Snædís; Ívarsdóttir, Erna V.; Tragante, Vinicius; Gunnarsson, Bjarni; Runolfsdottir, Hrafnhildur Linnet; Arthur, Joseph G; Deaton, Aimee M; Eyjolfsson, Gudmundur I; Davidsson, Olafur B; Asselbergs, Folkert W; Hreidarsson, Astradur B; Rafnar, Thorunn; Thorleifsson, Gudmar; Edvardsson, Vidar; Sigurdsson, Gunnar; Helgadottir, Anna; Halldórsson, Bjarni; Masson, Gisli; Holm, Hilma; Önundarson, Páll Torfi; Indridason, Olafur S; Benediktsson, Rafn; Palsson, Runolfur; Gudbjartsson, Daniel F; Olafsson, Isleifur; Thorsteinsdottir, Unnur; sulem, patrick; Stefansson, Kari (Oxford University Press (OUP), 2018-11-24)
    Urine dipstick tests are widely used in routine medical care to diagnose kidney and urinary tract and metabolic diseases. Several environmental factors are known to affect the test results, whereas the effects of genetic diversity are largely unknown. ...
  • Jacob, Deborah; Unnsteinsdóttir Kristensen, Ingunn S.; Aubonnet, Romain; Recenti, Marco; Donisi, Leandro; Ricciardi, Carlo; Svansson, Halldór Á.R.; Agnarsdóttir, Sólveig; Colacino, Andrea; Jónsdóttir, María K.; Kristjánsdóttir, Hafrún; Sigurjónsdóttir, Helga; Cesarelli, Mario; Eggertsdóttir Claessen, Lára Ósk; Hassan, Mahmoud; Petersen, Hannes; Gargiulo, Paolo (2022-05-30)
    Current diagnosis of concussion relies on self-reported symptoms and medical records rather than objective biomarkers. This work uses a novel measurement setup called BioVRSea to quantify concussion status. The paradigm is based on brain and muscle ...
  • Banea, Ovidiu Constantin (2022-01)
    Background: Repetitive transcranial magnetic stimulation (RTMS) has been suggested as a possible therapeutic alternative for patients with schizophrenia (SCZ) and treatment-resistant auditory verbal hallucinations (AVH). The aim of the studies presented ...
  • Curtis, Jeffrey R.; Weinblatt, Michael E.; Shadick, Nancy A.; Brahe, Cecilie H.; Østergaard, Mikkel; Hetland, Merete Lund; Sævarsdóttir, Sædís; Horton, Megan; Mabey, Brent; Flake, Darl D.; Ben-Shachar, Rotem; Sasso, Eric H.; Huizinga, T. W. (2021-01-04)
    BACKGROUND: The multi-biomarker disease activity (MBDA) test measures 12 serum protein biomarkers to quantify disease activity in RA patients. A newer version of the MBDA score, adjusted for age, sex, and adiposity, has been validated in two cohorts ...