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Browsing by Subject "Aged"

Browsing by Subject "Aged"

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  • Thórsson, Bolli; Guðmundsson, Elías Freyr; Sigurðsson, Gunnar; Aspelund, Thor; Guðnason, Vilmundur G. (2021-05)
    INTRODUCTION: The number of people with type 2 diabetes has increased in Iceland in the last few decades. We utilized the national database on prescribed medication from the Directorate of Health to estimate the prevalence and incidence of type 2 ...
  • Hjaltadóttir, Ingibjörg; Sigurdardottir, Arun K. (Læknafélag Íslands, 2015-02)
    Inngangur: Sykursýki er vaxandi vandamál meðal eldra fólks og einn af áhættuþáttum fyrir flutning á hjúkrunarheimili. Ennfremur er sjúkdómabyrði og lyfjanotkun þeirra sem eru með sykursýki oft meiri. Tilgangur rannsóknarinnar var að skoða algengi ...
  • Lárusdóttir, Katrín Júniána; Guðmundsson, Hjalti; Johnsen, Árni; Sigurðsson, Martin Ingi; Guðbjartsson, Tómas; Guomundsdóttir, Ingibjörg Jóna (2021-03)
    INTRODUCTION: Surgical aortic valve replacement (SAVR) has been the standard of treatment for aortic stenosis but transcatheter aortic valve implantation (TAVI) is increasingly used as treatment in Iceland and elsewhere. Our objective was to assess the ...
  • Halldórsson, Arnljótur Björn; Axelsson, Gísli Þór; Jónsson, Helgi Már; Ísaksson, Jóhann Davíð; Harðardóttir, Hrönn; Guðmundsson, Gunnar; Hansdóttir, Sif (2021-10)
    Introduction Infections due to COVID-19 can lead to life threatening pneumonia. Accompanying severe disease are more prominent pulmonary changes on Computed Tomography (CT) scan of the chest. The goal of this study was to describe pulmonary CT changes ...
  • Teitsdóttir, Unnur Diljá; Halldórsson, Skarphéðinn; Rolfsson, Óttar; Lund, Sigrún H.; Jónsdóttir, María Kristín; Snædal, Jón G.; Petersen, Pétur Henry (2021-05-04)
    BACKGROUND: Understanding how dysregulation in lipid metabolism relates to the severity of Alzheimer's disease (AD) pathology might be critical in developing effective treatments. OBJECTIVE: To identify lipid species in cerebrospinal fluid (CSF) ...
  • Kristinsdóttir, Inga Valgerður; Jónsson, Pálmi V.; Hjaltadóttir, Ingibjörg; Björnsdóttir, Kristín (2021-10-29)
    Background: Policymakers advocate extended residence in private homes as people age, rather than relocation to long-term care facilities. Consequently, it is expected that older people living in their own homes will be frailer and have more complex ...
  • Grönwall, Caroline; Liljefors, Lisa; Bang, Holger; Hensvold, Aase H.; Hansson, Monika; Mathsson-Alm, Linda; Israelsson, Lena; Joshua, Vijay; Svärd, Anna; Stålesen, Ragnhild; Titcombe, Philip J.; Steen, Johanna; Piccoli, Luca; Sherina, Natalia; Clavel, Cyril; Svenungsson, Elisabet; Gunnarsson, Iva; Sævarsdóttir, Sædís; Kastbom, Alf; Serre, Guy; Alfredsson, Lars; Malmström, Vivianne; Rönnelid, Johan; Catrina, Anca I.; Lundberg, Karin; Klareskog, Lars (2021-05-20)
    Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities. Yet, other serum anti-modified protein autoantibodies (AMPA), e.g. ...
  • Smaradottir, Maria Isabel; Andersen, Karl; Gudnason, Vilmundur; Näsman, Per; Rydén, Lars; Mellbin, Linda Garcia (2021-07)
    BACKGROUND: Elevated copeptin, a marker for vasopressin release, has been associated with impaired prognosis in acute myocardial infarction (MI). The aim was to investigate whether this association extends beyond the acute phase and whether it is related ...
  • Styrkarsdottir, Unnur; Lund, Sigrun H.; Sævarsdóttir, Sædís; Magnusson, Magnus I.; Gunnarsdottir, Kristbjorg; Norddahl, Gudmundur L.; Frigge, Michael L.; Ivarsdottir, Erna V.; Bjornsdottir, Gyda; Holm, Hilma; Thorgeirsson, Gudmundur; Rafnar, Thorunn; Jónsdóttir, Ingileif; Ingvarsson, Þorvaldur; Jónsson, Helgi; Sulem, Patrick; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; Stefansson, Kari (2021-11)
    Objective: Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods: Using ...
  • Chew, Michelle S.; Kattainen, Salla; Haase, Nicolai; Buanes, Eirik A.; Kristinsdóttir, Linda B.; Hofsø, Kristin; Laake, Jon Henrik; Kvåle, Reidar; Hästbacka, Johanna; Reinikainen, Matti; Bendel, Stepani; Varpula, Tero; Walther, Sten; Perner, Anders; Flaatten, Hans K.; Sigurðsson, Martin Ingi (2022-01)
    Background: We sought to provide a description of surge response strategies and characteristics, clinical management and outcomes of patients with severe COVID-19 in the intensive care unit (ICU) during the first wave of the pandemic in Denmark, Finland, ...
  • Brynjólfsson, Siggeir Fannar; Sigurgrímsdóttir, Hildur; Einarsdóttir, Elín D.; Björnsdóttir, Guðrún Ása; Ármannsdóttir, Brynja; Baldvinsdóttir, Guðrún E.; Bjarnason, Agnar; Guðlaugsson, Ólafur; Guðmundsson, Sveinn Viðar; Sigurðardóttir, Sigurveig T.; Löve, Arthur; Kristinsson, Karl Gústaf; Lúðvíksson, Björn Rúnar (2021-06-10)
    A detailed understanding of the antibody response against SARS-CoV-2 is of high importance, especially with the emergence of novel vaccines. A multiplex-based assay, analyzing IgG, IgM, and IgA antibodies against the receptor binding domain (RBD), spike ...
  • Kristiansen, Martin; Lindén, Christina; Qvarlander, Sara; Wåhlin, Anders; Ambarki, Khalid; Hallberg, Per; Eklund, Anders; Jóhannesson, Gauti (2020-11-19)
    Purpose: To examine feasibility of phase-contrast magnetic resonance imaging (PCMRI) and to assess blood flow rate in the ophthalmic artery (OA) in patients with normal tension glaucoma (NTG) compared with healthy controls. Methods: Sixteen patients ...
  • Nicoletti, Paola; Devarbhavi, Harshad; Goel, Ashish; Venkatesan, Radha; Eapen, Chundamannil E.; Grove, Jane I.; Zafer, Samreen; Björnsson, Einar Stefán; Lucena, M. Isabel; Andrade, Raul J.; Pirmohamed, Munir; Wadelius, Mia; Larrey, Dominique; Maitland-van der Zee, Anke Hilse; Ibanez, Luisa; Watkins, Paul B.; Daly, Ann K.; Aithal, Guruprasad P. (2021-04)
    Drug-induced liver injury (DILI) is a complication of treatment with antituberculosis (TB) drugs, especially in isoniazid (INH)-containing regimens. To investigate genetic risk factors, we performed a genomewide association study (GWAS) involving anti-TB ...
  • Konradsen, Hanne; Brødsgaard, Anne; Østergaard, Birte; Svavarsdóttir, Erla Kolbrún; Dieperink, Karin B.; Imhof, Lorenz; Luttik, Marie Louise; Mahrer-Imhof, Romy; García-Vivar, Cristina (2020-04-14)
    Introduction: In Europe, cancer is one of the predominant causes of mortality and morbidity among older people aged over 65. A diagnosis of cancer can imply a negative impact on the quality of life of the older patients and their families. Despite ...
  • Blondal, B S; Geirsdottir, O G; Halldorsson, T I; Beck, A M; Jónsson, Pálmi V; Ramel, A (2022-04)
    BACKGROUND AND AIMS: Malnutrition is common among older adults and is related to quality of life, cognitive function, and depression. To what extent nutrition interventions can improve these outcomes remains unclear. The aim of this study was to ...
  • Skuladottir, Astros Th; Bjornsdottir, Gyda; Thorleifsson, Gudmar; Walters, G. Bragi; Nawaz, Muhammad Sulaman; Moore, Kristjan Helgi Swerford; Olason, Pall I.; Thorgeirsson, Thorgeir E.; Sigurpalsdottir, Brynja; Sveinbjornsson, Gardar; Eggertsson, Hannes P.; Magnusson, Sigurdur H.; Oddsson, Asmundur; Bjornsdottir, Anna; Vikingsson, Arnor; Sveinsson, Olafur A.; Hrafnsdottir, Maria G.; Sigurdardottir, Gudrun R.; Halldorsson, Bjarni V.; Hansen, Thomas Folkmann; Paarup, Helene; Erikstrup, Christian; Nielsen, Kaspar; Klokker, Mads; Bruun, Mie Topholm; Sorensen, Erik; Banasik, Karina; Burgdorf, Kristoffer S.; Pedersen, Ole Birger; Ullum, Henrik; Jonsdottir, Ingileif; Stefansson, Hreinn; Stefansson, Kari (2021-02-18)
    Bell’s palsy is the most common cause of unilateral facial paralysis and is defined as an idiopathic and acute inability to control movements of the facial muscles on the affected side. While the pathogenesis remains unknown, previous studies have ...
  • Rögnvaldsson, Sæmundur; Eythorsson, Elias; Thorsteinsdottir, Sigrun; Vidarsson, Brynjar; Önundarson, Páll Torfi; Agnarsson, Bjarni Agnar; Sigurdardottir, Margret; Thorsteinsdóttir, Ingunn; Ólafsson, Ísleifur; Runólfsdóttir, Hrafnhildur L.; Helgason, Dadi; Emilsdóttir, Arna Rut; Ágústsson, Arnar Snær; Björnsson, Aron Hjalti; Kristjánsdóttir, Gudrún; Thordardottir, Asdis Rosa; Indridason, Olafur Skuli; Jónsson, Ásbjörn; Gislason, Gauti Kjartan; Olafsson, Andri; Steingrímsdóttir, Hlíf; Kampanis, Petros; Hultcrantz, Malin; Durie, Brian G.M.; Harding, Stephen; Landgren, Ola; Palsson, Runolfur; Love, Thorvarður Jon; Kristinsson, Sigurdur Yngvi (2021-12-01)
    Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of ...
  • the Chronic Kidney Disease Epidemiology Collaboration (2021-11-04)
    BACKGROUND: Current equations for estimated glomerular filtration rate (eGFR) that use serum creatinine or cystatin C incorporate age, sex, and race to estimate measured GFR. However, race in eGFR equations is a social and not a biologic construct. ...
  • Shen, Qing; Sjölander, Arvid; Sloan, Erica K.; Walker, Adam K.; Fall, Katja; Valdimarsdóttir, Unnur Anna; Sparén, Pär; Smedby, Karin E.; Fang, Fang (2022-01-17)
    Background: Cancer patients experience increased risk of death from accident and suicide. Cognitive impairment induced by cancer-related inflammation and stress-related psychiatric symptoms may be underlying mechanisms. We therefore studied the association ...
  • Eiriksdottir, Thjodbjorg; Ardal, Steinthor; Jonsson, Benedikt A.; Lund, Sigrun H.; Ivarsdottir, Erna V.; Norland, Kristjan; Ferkingstad, Egil; Stefansson, Hreinn; Jónsdóttir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Þorgeirsson, Guðmundur; Gudbjartsson, Daniel F.; Sulem, Patrick; Thorsteinsdottir, Unnur; Stefansson, Kari; Úlfarsson, Magnús Örn (2021-06-18)
    Predicting all-cause mortality risk is challenging and requires extensive medical data. Recently, large-scale proteomics datasets have proven useful for predicting health-related outcomes. Here, we use measurements of levels of 4,684 plasma proteins ...