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Browsing by Subject "Ónæmisfræði"

Browsing by Subject "Ónæmisfræði"

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  • Aradóttir Pind, Auður Anna; Dubik, Magdalena; Þórsdóttir, Sigrún; Meinke, Andreas; Harandi, Ali M.; Holmgren, Jan; Del Giudice, Giuseppe; Jonsdottir, Ingileif; Bjarnarson, Stefanía P (Frontiers Media SA, 2019-09-26)
    Immaturity of the immune system contributes to poor vaccine responses in early life. Germinal center (GC) activation is limited due to poorly developed follicular dendritic cells (FDC), causing generation of few antibody-secreting cells (ASCs) with ...
  • Hasan, Shakir; Kulkarni, Nikhil Nitin; Asbjarnarson, Arni; Linhartova, Irena; Osicka, Radim; Sebo, Peter; Gudmundsson, Gudmundur H (American Society for Microbiology, 2017-12-04)
    The airway epithelium restricts the penetration of inhaled pathogens into the underlying tissue and plays a crucial role in the innate immune defense against respiratory infections. The whooping cough agent, Bordetella pertussis, adheres to ciliated ...
  • Pardal, Sara; Drews, Anna; Alves, Jose; Ramos, Jaime A.; Westerdahl, Helena (Springer Nature, 2017-05-23)
    The major histocompatibility complex (MHC) encodes proteins that are central for antigen presentation and pathogen elimination. MHC class I (MHC-I) genes have attracted a great deal of interest among researchers in ecology and evolution and have been ...
  • Lemarquis, Andri Leo (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-06-03)
    Sértækur IgA skortur (sIgAD) er algengasti galli í sértæka ónæmiskerfinu. Gallinn er skilgreindur sem algjör skortur á IgA með eðlilegum IgG og IgM styrk í sermi. Tíðni sjúkdóma sem tengjast óeðlilegu ónæmissvari er hærri hjá sIgAD ...
  • Káradóttir, Harpa; Nikhil Nitin, Kulkarn; Guðjónsson, Þórarinn; Karason, Sigurbergur; Guðmundsson, Guðmundur Hrafn (PeerJ, 2015-12-07)
    Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense ...
  • Hjálmarsdóttir, Martha Ásdís (University of Iceland, School of Health Sciences, Faculty of Medcine, 2016-10-14)
    Streptococcus pneumoniae, pneumókokkar, sem ekki voru næmir fyrir penisillíni (PÓP) fundust fyrst á Íslandi 1988 og urðu á fjórum árum 20% allra pneumókokka stofna sem greindust hjá sjúklingum. Flestir voru þeir af hjúpgerð 6Bii/E, CC90. Árið 2011 ...
  • Thorsteinsdottir, Lilja (University of Iceland, School of Health Sciences, Faculty of Medicine, 2020-03)
    Íslenski hesturinn er eini hestastofninn á Íslandi. Hestar voru fluttir hingað við landnám og hafa verið hreinræktaðir síðan. Vegna landfræðilegrar einangrunar er stofninn berskjaldaður fyrir mörgum sjúkdómsvöldum sem herja á hesta í öðrum löndum. ...
  • Jonsdottir-Buch, Sandra Mjoll (University of Iceland, School of Health Sciences, Faculty of Medicine, 2017-09-15)
    Mesenchymal stromal cells (MSC) are promising candidates for cellular therapy due to their ability to regenerate bone and cartilage and modulate immune responses. The use of MSC in cellular therapy is problematic due to the need for fetal bovine serum ...
  • Hendriksen, Rene S.; Thorsteinsdottir, Thorunn Rafnar (Springer Science and Business Media LLC, 2019-03-08)
    Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome ...
  • Arnadottir, Gudny; Norðdahl, Guðmundur L.; Gudmundsdottir, Steinunn; Ágústsdóttir, Arna B.; Sigurðsson, Snævar; Jensson, Brynjar Örn; Bjarnadóttir, Kristbjörg; Theodórs, Fannar; Benonisdottir, Stefania; Ívarsdóttir, Erna V.; Oddsson, Asmundur; Kristjánsson, Ragnar P.; Sulem, Gerald; Alexandersson, Kristján F.; Júlíusdóttir, Þórhildur; Guðmundsson, Kjartan R.; Sæmundsdóttir, Jóna; Jónasdóttir, Aðalbjörg; Jónasdóttir, Áslaug; Sigurðsson, Ásgeir; Manzanillo, Paolo; Guðjónsson, Sigurjón Axel; Thorisson, Gudmundur A.; Magnússon, Ólafur Þ.; Másson, Gísli; Örvar, Kjartan B.; Holm, Hilma; Björnsson, Sigurður; Arngrimsson, Reynir; Gudbjartsson, Daniel; Thorsteinsdottir, Unnur; Jonsdottir, Ingileif; Haraldsson, Ásgeir; Sulem, Patrick; Stefansson, Kari (Springer Science and Business Media LLC, 2018-10-25)
    Mutations in genes encoding subunits of the phagocyte NADPH oxidase complex are recognized to cause chronic granulomatous disease (CGD), a severe primary immunodeficiency. Here we describe how deficiency of CYBC1, a previously uncharacterized protein ...
  • Bergman, Peter; Raqib, Rubhana; Rekha, Rokeya Sultana; Agerberth, Birgitta; Gudmundsson, Gudmundur H (Frontiers Media SA, 2020-06-12)
    The innate immune system constitutes the first line of defense against invading pathogens, regulating the normal microbiota and contributes to homeostasis. Today we have obtained detailed knowledge on receptors, signaling pathways, and effector molecules ...
  • Lemarquis, Andri Leo; Theodors, Fannar; Einarsdottir, Helga K.; Ludviksson, Bjorn (Frontiers Media SA, 2019-03-18)
    Objectives: It has recently been shown that individuals with selective IgA deficiency (sIgAD) have defective B cell responses both to T cell dependent and independent mimicking stimulations. The complex intracellular signaling pathways from different ...
  • Myszor, Iwona T.; Parveen, Zahida; Ottosson, Håkan; Bergman, Peter; Agerberth, Birgitta; Strömberg, Roger; Guðmundsson, Guðmundur H. (Springer Science and Business Media LLC, 2019-05-08)
    Aroylated phenylenediamines (APDs) are novel inducers of innate immunity enhancing cathelicidin gene expression in human bronchial epithelial cell lines. Here we present two newly developed APDs and aimed at defning the response and signaling pathways ...
  • Magnadottir, Bergljot; Hayes, Polly; Gísladóttir, Berglind; Bragason, Birkir; Hristova, Mariya; Nicholas, Anthony P.; Guðmundsdóttir, Sigríður; Lange, Sigrun (Elsevier BV, 2018-10)
    Pentraxins arefluid phase pattern recognition molecules that form an important part of the innate immunedefence and are conserved betweenfish and human. In Atlantic cod (Gadus morhuaL.), two pentraxin-likeproteins have been described, CRP-I and CRP-II. ...
  • Magnadottir, Bergljot; Hayes, Polly; Hristova, Mariya; Bragason, Birkir; Nicholas, Anthony P.; Dodds, Alister W.; Guðmundsdóttir, Sigríður; Lange, Sigrun (Elsevier BV, 2018-10)
    Peptidylarginine deiminases (PADs) are calcium dependent enzymes with physiological and pathophysiologicalroles conserved throughout phylogeny. PADs promote post-translational deimination of protein arginine to ci-trulline, altering the structure and ...
  • Di, Xiaxia (University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2019-01-07)
    A substantial diversity of secondary metabolites from marine invertebrates has been described; however, only a few studies have investigated secondary metabolites of marine invertebrates collected in Icelandic waters. The unique marine environment ...
  • Quirk, Sigríður Júlía (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-04)
    The pneumococcus is a major human pathogen that causes morbidity and mortality worldwide. Pneumococci are normally carried asymptomatically in the nasopharynx of healthy pre-school children. Pneumococcal infections can range from acute otitis media ...
  • Lemarquis, Andri Leo; Einarsdóttir, Helga K.; Kristjansdóttir, Rakel N.; Jonsdottir, Ingileif; Ludviksson, Bjorn (Frontiers Media SA, 2018-04-27)
    Selective IgA deficiency (IgAD) is the most common primary antibody deficiency in the western world with affected individuals suffering from an increased burden of autoimmunity, atopic diseases and infections. It has been shown that IgAD B cells can ...
  • Hanson, Charles; Arnarsson, Arsaell; Harðarson, Þórir; Lindgård, Ann; Daneshvarnaeini, Mandana; Ellerström, Catarina; Bruun, Anita; Stenevi, Ulf (Baishideng Publishing Group Inc., 2017)
    AIM To investigate whether human embryonic stem cells (hESCs) could be made to attach, grow and differentiate on a human Descemet’s membrane (DM). METHODS Spontaneously differentiated hESCs were transferred onto a human corneal button with the ...