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Browsing by Department "Clinical Laboratory Services, Diagnostics and Blood Bank"

Browsing by Department "Clinical Laboratory Services, Diagnostics and Blood Bank"

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  • Rögnvaldsson, Kristján G; Bjarnason, Agnar; Kristinsson, Karl; Bragason, Hörður T; Erlendsdóttir, Helga; Þorgeirsson, Guðmundur; Gottfreðsson, Magnús (2022-08)
    BACKGROUND: Pneumonia is commonly caused by Streptococcus pneumoniae (pneumococcus) and associated with subsequent cardiovascular complications and increased mortality. Potential short-term survival benefits conferred by acetylsalicylic acid (ASA) use ...
  • Miettinen, Juho J.; Kumari, Romika; Traustadóttir, Gunnhildur Ásta; Huppunen, Maiju Emilia; Sergeev, Philipp; Majumder, Muntasir M.; Schepsky, Alexander; Guðjónsson, Þórarinn; Lievonen, Juha; Bazou, Despina; Dowling, Paul; O‘gorman, Peter; Slipicevic, Ana; Anttila, Pekka; Silvennoinen, Raija; Nupponen, Nina N.; Lehmann, Fredrik; Heckman, Caroline A. (2021-03-26)
    Multiple myeloma (MM) is characterized by extensive immunoglobulin production leading to an excessive load on protein homeostasis in tumor cells. Aminopeptidases contribute to proteolysis by catalyzing the hydrolysis of amino acids from proteins or ...
  • Karvelsson, Sigurður Trausti; Wang, Qiong; Hilmarsdóttir, Bylgja; Sigurðsson, Arnar; Moestue, Siver Andreas; Mælandsmo, Gunhild Mari; Halldórsson, Skarphédinn; Guðmundsson, Steinn; Rolfsson, Óttar (2021-09-17)
    Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic phenotypes ...
  • Liyanarachchi, Sandya; Gudmundsson, Julius; Ferkingstad, Egil; He, Huiling; Jónasson, Jón Gunnlaugur; Tragante, Vinicius; Asselbergs, Folkert W.; Xu, Li; Kiemeney, Lambertus A.; Netea-Maier, Romana T.; Mayordomo, Jose I.; Plantinga, Theo S.; Hjartarson, Hannes; Hrafnkelsson, Jón; Sturgis, Erich M.; Brock, Pamela; Nabhan, Fadi; Thorleifsson, Gudmar; Ringel, Matthew D.; Stefansson, Kari; de la Chapelle, Albert (2020-03-17)
    Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed ...
  • on behalf of The Euro-GASP Network (2021-03-18)
    BACKGROUND: The emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae, nationally and internationally, is a serious threat to the management and control of gonorrhoea. Limited and conflicting data regarding the epidemiological ...
  • Burden of AMR Collaborative Group (2019-01)
    Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by ...
  • Isberg, Olof Gerdur; Giunchiglia, Valentina; McKenzie, James S.; Takats, Zoltan; Jonasson, Jon Gunnlaugur; Bodvarsdottir, Sigridur Klara; Thorsteinsdottir, Margret; Xiang, Yuchen (2022-05-18)
    Optical microscopy has long been the gold standard to analyse tissue samples for the diagnostics of various diseases, such as cancer. The current diagnostic workflow is time-consuming and labour-intensive, and manual annotation by a qualified pathologist ...
  • Harðardóttir, Ingibjörg; Anderson, Kimberley Jade; Ósvaldsdóttir, Árný Björg; Atzinger, Birgit; Traustadóttir, Gunnhildur Ásta; Jensen, Kirstine Nolling; Lárusdóttir, Aðalheiður Elín; Bergþórsson, Jón Þór; Magnúsdóttir, Erna (2020-07-09)
    Waldenström’s macroglobulinemia (WM) is a non-Hodgkin lymphoma, resulting in antibody-secreting lymphoplasmacytic cells in the bone marrow and pathologies resulting from high levels of monoclonal immunoglobulin M (IgM) in the blood. Despite the key ...
  • Stefánsson, Ólafur A.; Hilmarsdóttir, Hólmfridur; Ólafsdóttir, Kristrún; Tryggvadóttir, Laufey; Sverrisdóttir, Ásgerdur; Jóhannsson, Óskar Þór; Jónasson, Jón Gunnlaugur; Eyfjörð, Jórunn Erla; Sigurdsson, Stefán Þórarinn (2019-12-11)
    Background: Breast Cancer 1 gene (BRCA1) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in BRCA1 are sensitive to cytotoxic drugs that cause DNA double strand breaks. However, ...
  • GEMO Study Collaborators; EMBRACE Collaborators; kConFab Investigators; HEBON Investigators; Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (2021-07-28)
    BACKGROUND: Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant ...
  • Olafsdottir, Elinborg J.; Borg, Ake; Jensen, Maj Britt; Gerdes, Anne Marie; Johansson, Anna L.V.; Barkardottir, Rosa B.; Johannsson, Oskar T.; Ejlertsen, Bent; Sønderstrup, Ida Marie Heeholm; Hovig, Eivind; Lænkholm, Anne Vibeke; Hansen, Thomas van Overeem; Olafsdottir, Gudridur H.; Rossing, Maria; Jonasson, Jon G.; Sigurdsson, Stefan; Loman, Niklas; Nilsson, Martin P.; Narod, Steven A.; Tryggvadottir, Laufey (2020-11-24)
    Background: The natural history of breast cancer among BRCA2 carriers has not been clearly established. In a previous study from Iceland, positive ER status was a negative prognostic factor. We sought to identify factors that predicted survival after ...
  • Ingþórsson, Sævar; Traustadóttir, Gunnhildur Ásta; Guðjónsson, Þórarinn (2022-10-24)
    The human breast gland is a unique organ as most of its development occurs postnatally between menarche and menopause, a period ranging from 30 to 40 years. During this period, the monthly menstruation cycle drives the mammary gland through phases of ...
  • PSERENADE Team (2021-03-27)
    Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococ-cal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) con-taining ST1 antigen. The Pneumococcal Serotype Replacement and ...
  • Brueggemann, Angela B.; Jansen van Rensburg, Melissa J.; Shaw, David; McCarthy, Noel D.; Jolley, Keith A.; Maiden, Martin C.J.; van der Linden, Mark P.G.; Amin-Chowdhury, Zahin; Bennett, Désirée E.; Borrow, Ray; Brandileone, Maria Cristina C.; Broughton, Karen; Campbell, Ruth; Cao, Bin; Casanova, Carlo; Choi, Eun Hwa; Chu, Yiu Wai; Clark, Stephen A.; Claus, Heike; Coelho, Juliana; Corcoran, Mary; Cottrell, Simon; Cunney, Robert J.; Dalby, Tine; Davies, Heather; de Gouveia, Linda; Deghmane, Ala Eddine; Demczuk, Walter; Desmet, Stefanie; Drew, Richard J.; du Plessis, Mignon; Erlendsdóttir, Helga; Fry, Norman K.; Fuursted, Kurt; Gray, Steve J.; Henriques-Normark, Birgitta; Hale, Thomas; Hilty, Markus; Hoffmann, Steen; Humphreys, Hilary; Ip, Margaret; Jacobsson, Susanne; Johnston, Jillian; Kozakova, Jana; Kristinsson, Karl Gústaf; Krizova, Pavla; Kuch, Alicja; Ladhani, Shamez N.; Lâm, Thiên Trí; Lebedova, Vera; Lindholm, Laura; Litt, David J.; Martin, Irene; Martiny, Delphine; Mattheus, Wesley; McElligott, Martha; Meehan, Mary; Meiring, Susan; Mölling, Paula; Morfeldt, Eva; Morgan, Julie; Mulhall, Robert M.; Muñoz-Almagro, Carmen; Murdoch, David R.; Murphy, Joy; Musilek, Martin; Mzabi, Alexandre; Perez-Argüello, Amaresh; Perrin, Monique; Perry, Malorie; Redin, Alba; Roberts, Richard; Roberts, Maria; Rokney, Assaf; Ron, Merav; Scott, Kevin J.; Sheppard, Carmen L.; Siira, Lotta; Skoczyńska, Anna; Sloan, Monica; Slotved, Hans Christian; Smith, Andrew J.; Song, Joon Young; Taha, Muhamed Kheir; Toropainen, Maija; Tsang, Dominic; Vainio, Anni; van Sorge, Nina M.; Varon, Emmanuelle; Vlach, Jiri; Vogel, Ulrich; Vohrnova, Sandra; von Gottberg, Anne; Zanella, Rosemeire C.; Zhou, Fei (2021-06)
    Background: Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis, which are typically transmitted via respiratory droplets, are leading causes of invasive diseases, including bacteraemic pneumonia and meningitis, and of secondary ...
  • Weiner, January; Lewis, David J.M.; Maertzdorf, Jeroen; Mollenkopf, Hans Joachim; Bodinham, Caroline; Pizzoferro, Kat; Linley, Catherine; Greenwood, Aldona; Mantovani, Alberto; Bottazzi, Barbara; Denoel, Philippe; Leroux-Roels, Geert; Kester, Kent E.; Jonsdottir, Ingileif; van den Berg, Robert; Kaufmann, Stefan H.E.; Del Giudice, Giuseppe (2019-12-01)
    Biomarkers predictive of inflammatory events post-vaccination could accelerate vaccine development. Within the BIOVACSAFE framework, we conducted three identically designed, placebo-controlled inpatient/outpatient clinical studies (NCT01765413/NCT017 ...
  • Hilmarsdóttir, Ingibjörg; Arnardóttir, Eva Mjöll; Jóhannesdóttir, Elísabet Reykdal; Golparian, Daniel; Unemo, Magnus (2021-02)
    The aims of this study were to assess the prevalence of, and risk factors for, Chlamydia trachomatis in at-tendees recruited prospectively from October 2018 to January 2019 at the only sexually transmitted infections clinic in Iceland (in Reykjavík), ...
  • Faundes, Víctor; Goh, Stephanie; Akilapa, Rhoda; Bezuidenhout, Heidre; Björnsson, Hans Tómas; Bradley, Lisa; Brady, Angela F.; Brischoux-Boucher, Elise; Brunner, Han; Bulk, Saskia; Canham, Natalie; Cody, Declan; Dentici, Maria Lisa; Digilio, Maria Cristina; Elmslie, Frances; Fry, Andrew E.; Gill, Harinder; Hurst, Jane; Johnson, Diana; Julia, Sophie; Lachlan, Katherine; Lebel, Robert Roger; Byler, Melissa; Gershon, Eric; Lemire, Edmond; Gnazzo, Maria; Lepri, Francesca Romana; Marchese, Antonia; McEntagart, Meriel; McGaughran, Julie; Mizuno, Seiji; Okamoto, Nobuhiko; Rieubland, Claudine; Rodgers, Jonathan; Sasaki, Erina; Scalais, Emmanuel; Scurr, Ingrid; Suri, Mohnish; van der Burgt, Ineke; Matsumoto, Naomichi; Miyake, Noriko; Benoit, Valérie; Lederer, Damien; Banka, Siddharth (2021-07)
    Purpose: The variant spectrum and the phenotype of X-linked Kabuki syndrome type 2 (KS2) are poorly understood. Methods: Genetic and clinical details of new and published individuals with pathogenic KDM6A variants were compiled and analyzed. Results: ...
  • GEMO Study Collaborators; EMBRACE Collaborators; SWE-BRCA Investigators; kConFab Investigators; HEBON Investigators (2022-10-06)
    The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740 ...
  • Sigurdardottir, Anna Karen; Jonasdottir, Arna Steinunn; Asbjarnarson, Arni; Helgudottir, Hildur Run; Gudjonsson, Thorarinn; Traustadottir, Gunnhildur Asta (2021-12)
    Due to an error during typesetting, an incomplete Supplementary file was originally published with this article. Supplementary figures were missing and this has now been uploaded. The original article has been corrected.
  • Styrkarsdottir, Unnur; Lund, Sigrun H.; Sævarsdóttir, Sædís; Magnusson, Magnus I.; Gunnarsdottir, Kristbjorg; Norddahl, Gudmundur L.; Frigge, Michael L.; Ivarsdottir, Erna V.; Bjornsdottir, Gyda; Holm, Hilma; Thorgeirsson, Gudmundur; Rafnar, Thorunn; Jónsdóttir, Ingileif; Ingvarsson, Þorvaldur; Jónsson, Helgi; Sulem, Patrick; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; Stefansson, Kari (2021-11)
    Objective: Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods: Using ...