Opin vísindi

Browsing by Department "Biomedical Center (UI)"

Browsing by Department "Biomedical Center (UI)"

Sort by: Order: Results:

  • Plomp, Kimberly A.; Dobney, Keith; Weston, Darlene A.; Viðarsdóttir, Una Strand; Collard, Mark (Springer Science and Business Media LLC, 2019-12-16)
    Background: Recently we proposed an evolutionary explanation for a spinal pathology that afflicts many people, intervertebral disc herniation (Plomp et al. [2015] BMC Evolutionary Biology 15, 68). Using 2D data, we found that the bodies and pedicles ...
  • Di, Xiaxia; Rouger, Caroline; Hardardottir, Ingibjorg; Freysdottir, Jona; Molinski, Tadeusz; Tasdemir, Deniz; Omarsdottir, Sesselja (MDPI AG, 2018-11-08)
    An UPLC-qTOF-MS-based dereplication study led to the targeted isolation of seven bromoindole alkaloids from the sub-Arctic sponge Geodia barretti. This includes three new metabolites, namely geobarrettin A–C (1–3) and four known compounds, barettin ...
  • Arason, Adalgeir; Agnarsson, Bjarni A.; Jóhannesdóttir, Gudrún; Jóhannsson, Óskar Th; Hilmarsdóttir, Bylgja; Reynisdóttir, Inga; Barkardottir, Rosa Bjork (MDPI AG, 2019-11-01)
    Mutations in BRCA1 result in predisposal to breast and ovarian cancers, but many variants exist with unknown clinical significance (VUS). One is BRCA1 c.4096+3A>G, which affects production of the full-length BRCA1 transcript, while augmenting transcripts ...
  • Ísberg, Ólöf Gerður; Kim, Jiyoung; Fridriksdottir, Agla; Morsing, Mikkel; Timmermans-Wielenga, Vera; Rønnov-Jessen, Lone; Petersen, Ole W.; Villadsen, René (Springer Science and Business Media LLC, 2019-10-16)
    Human breast cancer is believed to arise in luminal progenitors within the normal breast. A subset of these are double positive (DP) for basal and luminal keratins and localizes to a putative stem cell zone within ducts. We here present a new protocol ...
  • Káradóttir, Harpa; Nikhil Nitin, Kulkarn; Guðjónsson, Þórarinn; Karason, Sigurbergur; Guðmundsson, Guðmundur Hrafn (PeerJ, 2015-12-07)
    Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense ...
  • Pashay Ahi, Ehsan; Steinhäuser, Sophie S.; Palsson, Arnar; Franzdottir, Sigridur Rut; Snorrason, Sigurdur S.; Maier, Valerie H.; Jónsson, Zophonías Oddur (Springer Nature, 2015-09-16)
    Background The developmental basis of craniofacial morphology hinges on interactions of numerous signalling systems. Extensive craniofacial variation in the polymorphic Arctic charr, a member of the salmonid family, from Lake Thingvallavatn (Iceland), ...
  • Guðbrandsson, Jóhannes; Franzdottir, Sigridur Rut; Kristjansson, Bjarni K.; Pashay Ahi, Ehsan; Maier, Valerie H.; Kapralova, Kalina; Snorrason, Sigurdur S; Jónsson, Zophonías Oddur; Palsson, Arnar (PeerJ, 2018-02-07)
    Phenotypic differences between closely related taxa or populations can arise through genetic variation or be environmentally induced, leading to altered transcription of genes during development. Comparative developmental studies of closely related ...
  • Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Erlendsdóttir, Helga; Hjálmarsdóttir, Martha Ásdís; van Tonder, Andries J.; Hrafnkelsson, Birgir; Sigurdsson, Samuel; Bentley, Stephen D.; Haraldsson, Ásgeir; Brueggemann, Angela B.; Kristinsson, Karl G. (American Society for Microbiology, 2018-09-26)
    Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the serotypes, genetic lineages, and antimicrobial susceptibility of pneumococci isolated from ...
  • Piqué, Laia; Martinez de Paz, Alexia; Piñeyro, David; Martínez-Cardús, Anna; Castro de Moura, Manuel; Llinàs-Arias, Pere; Setien, Fernando; Gomez-Miragaya, Jorge; Gonzalez-Suarez, Eva; Sigurdsson, Stefan; Jónasson, Jón G.; Villanueva, Alberto; Vidal, August; Davalos, Veronica; Esteller, Manel (Springer Science and Business Media LLC, 2019-08-13)
    Human tumors show altered patterns of protein isoforms that can be related to the dysregulation of messenger RNA alternative splicing also observed in transformed cells. Although somatic mutations in core spliceosome components and their associated ...
  • Guðbrandsson, Jóhannes; Kapralova, Kalina; Franzdottir, Sigridur Rut; Bergsveinsdóttir, Þóra Margrét; Hafstað, Völundur; Jónsson, Zophonías Oddur; Snorrason, Sigurður S.; Palsson, Arnar (Wiley, 2019-09-12)
    The availability of diverse ecological niches can promote adaptation of trophic specializations and related traits, as has been repeatedly observed in evolutionary radiations of freshwater fish. The role of genetics, environment, and history in ...
  • Figlioli, Gisella; Agnarsson, Bjarni A.; Barkardottir, Rosa Bjork (Springer Science and Business Media LLC, 2019-11-01)
    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has ...
  • Gudmundsson, Julius; Sigurðsson, Jón K.; Stefánsdóttir, Lilja; Agnarsson, Bjarni A.; Ísaksson, Helgi J.; Stefánsson, Ólafur A.; Guðjónsson, Sigurjón Axel; Gudbjartsson, Daniel; Másson, Gísli; Frigge, Michael L.; Stacey, Simon N.; Sulem, Patrick; Halldorsson, Gisli; Tragante, Vinicius; Holm, Hilma; Eyjólfsson, Guðmundur I.; Sigurðardóttir, Ólöf; Olafsson, Isleifur; Jónsson, Þorvaldur; Jónsson, Eirikur; Barkardóttir, Rósa B.; Hilmarsson, Rafn; Asselbergs, Folkert W.; Geirsson, Guðmundur; Thorsteinsdottir, Unnur; Rafnar, Thorunn; Thorleifsson, Gudmar; Stefansson, Kari (Springer Science and Business Media LLC, 2018-11-08)
    Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients ...
  • Rekha, Rokeya Sultana; Mily, Akhirunnesa; Sultana, Tajnin; Haq, Ahsanul; Ahmed, Sultan; Mostafa Kamal, S. M.; van Schadewijk, Annemarie; Hiemstra, Pieter S.; Guðmundsson, Guðmundur Hrafn; Agerberth, Birgitta; Raqib, Rubhana (Springer Nature, 2018-07-04)
    Background We have previously shown that 8 weeks’ treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D3 (vitD3) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum culture conversion and increased ...
  • Pan, Li-Long; Deng, Yuan-Yuan; Wang, Ruxing; Wu, Chengfei; Li, Jiahong; Niu, Wenying; Yang, Qin; Bhatia, Madhav; Guðmundsson, Guðmundur Hrafn; Agerberth, Birgitta; Diana, Julien; Sun, Jia (Frontiers Media SA, 2018-04-17)
    Acute pancreatitis (AP) is one common clinical acute abdominal disease, for which specific pharmacological or nutritional therapies remain elusive. Lactose, a macronutrient and an inducer of host innate immune responses, possesses immune modulatory ...
  • Halldorsson, Skarphedinn; Rohatgi, Neha; Magnúsdóttir, Manuela; Choudhary, Kumari Sonal; Gudjonsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdóttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild M.; Guðmundsson, Steinn; Rolfsson, Óttar (Elsevier BV, 2017-06)
    Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
  • García-Llorca, Andrea; Gudmundsdottir Aspelund, Snaefridur; Ogmundsdottir, Margret H; Steingrimsson, Eirikur; Eysteinsson, Thor (Springer Science and Business Media LLC, 2019-10-28)
    Mutations in the microphthalmia-associated transcription factor (Mitf) gene can cause retinal pigment epithelium (RPE) and retinal dysfunction and degeneration. We examined retinal and RPE structure and function in 3 month old mice homo- or heterozygous ...
  • Möller, Katrin; Sigurbjornsdottir, Sara; Arnþórsson, Ásgeir O.; Pogenberg, Vivian; Dilshat, Ramile; Fock, Valerie; Brynjólfsdóttir, Sólveig Hlín; Bindesboll, Christian; Bessadóttir, Margrét; Ögmundsdóttir, Helga M.; Simonsen, Anne; Larue, Lionel; Wilmanns, Matthias; Thorsson, Vésteinn; Steingrimsson, Eirikur; Ogmundsdottir, Margret H (Springer Science and Business Media LLC, 2019-01-31)
    The MITF transcription factor is a master regulator of melanocyte development and a critical factor in melanomagenesis. The related transcription factors TFEB and TFE3 regulate lysosomal activity and autophagy processes known to be important in ...
  • Zhang, T.; Zhou, Q.; Ogmundsdottir, Margret H; Möller, Katrín; Siddaway, R.; Larue, L.; Hsing, M.; Kong, S. W.; Goding, C. R.; Palsson, Arnar; Steingrimsson, Eirikur; Pignoni, F. (The Company of Biologists, 2015-06-19)
    The v-ATPase is a fundamental eukaryotic enzyme that is central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well documented, our knowledge of mechanisms that regulate v-ATPase activity is limited. Here, we ...
  • Myszor, Iwona T.; Parveen, Zahida; Ottosson, Håkan; Bergman, Peter; Agerberth, Birgitta; Strömberg, Roger; Guðmundsson, Guðmundur H. (Springer Science and Business Media LLC, 2019-05-08)
    Aroylated phenylenediamines (APDs) are novel inducers of innate immunity enhancing cathelicidin gene expression in human bronchial epithelial cell lines. Here we present two newly developed APDs and aimed at defning the response and signaling pathways ...
  • Teitsdóttir, Unnur Diljá; Arnardóttir, Erna Sif; Björnsdóttir, Erla; Gíslason, Þórarinn; Petersen, Petur Henry (Springer Nature, 2018-10-11)
    Purpose The inflammatory markers chitinase-3-like protein 1 (CHI3L1) and chitotriosidase (CHIT1) have both been associated with cardiovascular complications. The aim of this preliminary observational study was to assess the roles and interaction ...