Browsing by Author "Schipper, Nicolaas"

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Preparative Synthesis of an RP-Guanosine-3′,5′-Cyclic Phosphorothioate Analogue, a Drug Candidate for the Treatment of Retinal Degenerations

Pérez, Oswaldo; Schipper, Nicolaas; Bollmark, Martin (American Chemical Society, 2021-10-19)

Cyclic guanosine monophosphorothioate analogue 1a is currently showing potential as a drug for the treatment of inherited retinal neurodegenerations. To support ongoing preclinical and clinical work, we have developed a diastereoselective synthesis via ...
Structural Characterization Study of a Lipid Nanocapsule Formulation Intended for Drug Delivery Applications Using Small-Angle Scattering Techniques

Urimi, Dileep; Hellsing, Maja; Mahmoudi, Najet; Söderberg, Christopher; Widenbring, Ronja; Gedda, Lars; Edwards, Katarina; Loftsson, Thorsteinn; Schipper, Nicolaas (2022-02-28)

Lipid nanocapsules (LNCs) are increasingly being used for various drug delivery applications due to their versatile nature and ability to carry a wide variety of therapeutic drug molecules. In the present investigation, small-angle X-ray (SAXS) and ...

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