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Browsing by Author "Tryggvadóttir, Laufey"

Browsing by Author "Tryggvadóttir, Laufey"

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    Brca1 promoter methylation status in 1031 primary breast cancers predicts favorable outcomes following chemotherapy 
    Stefánsson, Ólafur A.; Hilmarsdóttir, Hólmfridur; Ólafsdóttir, Kristrún; Tryggvadóttir, Laufey; Sverrisdóttir, Ásgerdur; Jóhannsson, Óskar Þór; Jónasson, Jón Gunnlaugur; Eyfjörð, Jórunn Erla; Sigurdsson, Stefán Þórarinn (2019-12-11)
    Background: Breast Cancer 1 gene (BRCA1) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in BRCA1 are sensitive to cytotoxic drugs that cause DNA double strand breaks. However, ...
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    CpG promoter hypo-methylation and up-regulation of microRNA-190b in hormone receptor-positive breast cancer 
    Frick, Elisabet; Gudjonsson, Thorkell; Eyfjörð, Jórunn Erla; Jonasson, Jon; Tryggvadóttir, Laufey; Stefansson, Olafur; Sigurdsson, Stefan (Impact Journals, LLC, 2019-07-23)
    Estrogen receptor-positive breast cancer is subdivided into subtypes LuminalA and LuminalB, based on different expression patterns. MicroRNA-190b has been reported to be up-regulated in estrogen receptor-positive breast cancers. In this study we aimed ...
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    Samanburður á greiningu og meðferð ífarandi brjóstakrabbameina milli Íslands og Svíþjóðar 
    Gísladóttir, Lilja Dögg; Birgisson, Helgi; Agnarsson, Bjarni Agnar; Jónsson, Þorvaldur; Tryggvadóttir, Laufey; Sverrisdóttir, Ásgerður (2020-09)
    TILGANGUR Rannsóknin var liður í innleiðingu gæðaskráningar brjóstakrabbameina á Íslandi og markmiðið að bera saman greiningu og meðferð ífarandi brjóstakrabbameina á Íslandi og í Svíþjóð. EFNIVIÐUR OG AÐFERÐIR Upplýsingar um alla einstaklinga sem ...
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    Skimun fyrir krabbameinum í ristli og endaþarmi : Yfirlitsgrein um nýgengi, dánartíðni, kostnað og árangur 
    Birgisson, Helgi; Ólafsdóttir, Elínborg J.; Sverrisdóttir, Anna; Einarsson, Sigurður; Smáradóttir, Agnes; Tryggvadóttir, Laufey (2021-09-03)
    In this article the incidence and mortality for cancer of the colon and rectum in Iceland is discussed. The two most common screening methods, faecal immunochemical test (FIT) and colonoscopy are compared and an estimate of cost and benefits for the ...
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    Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination 
    Steinþórsdóttir, Valgerður; Halldórsson, Bjarni Vilhjálmur; Jónsson, Hákon; Palsson, Gunnar; Oddsson, Ásmundur; Westergaard, David; Arnadottir, Gudny A.; Stefánsdóttir, Lilja; Banasik, Karina; Esplin, M. Sean; Hansen, Thomas Folkmann; Brunak, Søren; Nyegaard, Mette; Ostrowski, Sisse Rye; Pedersen, Ole Birger Vesterager; Erikstrup, Christian; Thorleifsson, Gudmar; Nadauld, Lincoln D.; Haraldsson, Ásgeir; Steingrímsdóttir, Þóra; Tryggvadóttir, Laufey; Jónsdóttir, Ingileif; Gudbjartsson, Daniel F.; Hoffmann, Eva R.; Sulem, Patrick; Hólm, Hilma; Nielsen, Henriette Svarre; Stefánsson, Kári (2024-01-29)
    Two-thirds of all human conceptions are lost, in most cases before clinical detection. The lack of detailed understanding of the causes of pregnancy losses constrains focused counseling for future pregnancies. We have previously shown that a missense ...