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Fletta eftir höfundi "Jónasson, Jón Gunnlaugur"
Atriði 1-14 af 14
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(2020-03-17)Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed ... -
(2022-05-18)Optical microscopy has long been the gold standard to analyse tissue samples for the diagnostics of various diseases, such as cancer. The current diagnostic workflow is time-consuming and labour-intensive, and manual annotation by a qualified pathologist ...
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(2019-12-11)Background: Breast Cancer 1 gene (BRCA1) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in BRCA1 are sensitive to cytotoxic drugs that cause DNA double strand breaks. However, ...
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(Springer Nature, 2017-05-03)Lynch syndrome, caused by germline mutations in the mismatch repair genes, is associated with increased cancer risk. Here using a large whole-genome sequencing data bank, cancer registry and colorectal tumour bank we determine the prevalence of Lynch ...
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(Springer Nature, 2017-07-05)Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E. coli AlkB homologs ...
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(2021-11)Background: Metabolites, especially lipids, have been shown to be promising therapeutic targets. In conjugation with genes and proteins they can be used to identify phenotypes of disease and support the development of targeted treatments. The majority ...
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(2023-11-30)Estrogen receptor-positive (ER+) breast cancer generally confers a more favorable prognosis than ER-negative cancer, however, a different picture is emerging for BRCA2 mutation carriers and young patients. We used nationwide data from population-based ...
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(2016-03-02)Inngangur: Magakrabbamein var algengasta krabbameinið á Íslandi upp úr miðri 20. öld en er nú einungis 2-3% krabbameina. Markmið þessarar rannsóknar var að gera faraldsfræðilegan samanburð á tveimur meginflokkum kirtilfrumukrabbameina í maga samkvæmt ...
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(2019-09)INNGANGUR Frumkomin trefjunargallgangabólga er langvinnur bólgusjúkdómur í gallvegum innan og/eða utan lifrar sem getur valdið skorpulifur, lokastigs lifrarbilun og leitt til lifrarígræðslu. Bólgusjúkdómar í meltingarvegi, fyrst og fremst sáraristilbólga, ...
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(2023-10-19)Background: The TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include histopathological assessments of the tumour, tumour mutations and proteins in the blood. As some of these factors ...
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(2020)Lifrarbólga E er veirusjúkdómur sem berst yfirleitt með menguðu vatni og gengur oftast yfir án sértækra inngripa. Hann er algengur á Indlandi og hefur valdið faröldrum, til að mynda í Asíu, Afríku og Mexíkó, en er sjaldséður á Íslandi. Hér er lýst ...
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(2022-09-08)INNGANGUR Krabbamein í lifur, gallgangakerfi innan lifrar og gallblöðru ásamt meinvörpum í lifur, eru illvígir sjúkdómar með slæmar horfur. Skurðaðgerð er mikilvægasta meðferðin, sé hún gerð í læknandi tilgangi. Markmið rannsóknarinnar var að kanna ...
Atriði 1-14 af 14