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Fletta eftir höfundi "Jóelsson, Jón Pétur"

Fletta eftir höfundi "Jóelsson, Jón Pétur"

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    Azithromycin ameliorates sulfur dioxide-induced airway epithelial damage and inflammatory responses 
    Jóelsson, Jón Pétur; Kricker, Jennifer; Arason, Ari Jon; Sigurdsson, Snaevar; Valdimarsdóttir, Bryndís; Garðarsson, Friðrik Rúnar; Page, Clive P.; Lehmann, Fredrik; Gudjonsson, Thorarinn; Ingthorsson, Saevar (Springer Science and Business Media LLC, 2020-09-10)
    Background: The airway epithelium (AE) forms the first line of defence against harmful particles and pathogens. Barrier failure of the airway epithelium contributes to exacerbations of a range of lung diseases that are commonly treated with Azithromycin ...
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    Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia 
    Arason, Ari Jon; Jóelsson, Jón Pétur; Valdimarsdóttir, Bryndís; Sigurdsson, Snaevar; Guðjónsson, Alexander; Halldorsson, Skarphedinn; Jóhannsson, Freyr; Rolfsson, Óttar; Lehmann, Fredrik; Ingthorsson, Saevar; Cherek, Paulina; Gudmundsson, Gudmundur H; Garðarsson, Friðrik R.; Page, Clive P.; Baldursson, Ólafur; Gudjonsson, Thorarinn; Kricker, Jennifer (Springer Science and Business Media LLC, 2019-06-24)
    BACKGROUND: Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other ...
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    Melflufen, a peptide‐conjugated alkylator, is an efficient anti‐neo‐plastic drug in breast cancer cell lines 
    Schepsky, Alexander; Traustadóttir, Gunnhildur Ásta; Jóelsson, Jón Pétur; Ingþórsson, Sævar; Kricker, Jennifer; Bergthorsson, Jon Thor; Ásbjarnarson, Árni; Gudjonsson, Thorkell; Nupponen, Nina; Slipicevic, Ana; Lehmann, Fredrik; Gudjonsson, Thorarinn (Wiley, 2020-07-27)
    Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide-conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells, where it is ...
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    Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model 
    Jóelsson, Jón Pétur; Ásbjarnarson, Árni; Sigurðsson, Snævar; Kricker, Jennifer; Valdimarsdottir, Bryndis; Thorarinsdottir, Holmfridur; Starradottir, Eir; Guðjónsson, Þórarinn; Ingþórsson, Sævar; Kárason, Sigurbergur (2022-07-22)
    BACKGROUND: Mechanical ventilation is a life-saving therapy for critically ill patients, providing rest to the respiratory muscles and facilitating gas exchange in the lungs. Ventilator-induced lung injury (VILI) is an unfortunate side effect of ...