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Browsing by Author "Haraldsson, Gunnsteinn"

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Comparison of Serotype Prevalence of Pneumococci Isolated from Middle Ear, Lower Respiratory Tract and Invasive Disease Prior to Vaccination in Iceland

Hjálmarsdóttir, Martha Ásdís; Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Erlendsdóttir, Helga; Haraldsson, Ásgeir; Kristinsson, Karl G. (Public Library of Science (PLoS), 2017-01-26)

Background Information on pneumococcal serotype distribution before vaccination is a prerequisite for evaluation of vaccine effect. The aim was to investigate the prevalence of pneumococcal serotypes isolated from middle ear (ME), lower respiratory ...
The Effect of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine on H. influenzae in Healthy Carriers and Middle Ear Infections in Iceland

Sveinsdóttir, Hildigunnur; Björnsdóttir, Jana Birta; Erlendsdóttir, Helga; Hjálmarsdóttir, Martha Ásdís; Hrafnkelsson, Birgir; Haraldsson, Ásgeir; Kristinsson, Karl G.; Haraldsson, Gunnsteinn (American Society for Microbiology, 2019-05-08)

Vaccinations with the 10-valent pneumococcal conjugated vaccine (PHiD-CV) started in Iceland in 2011. Protein D (PD) from H. influenzae, which is coded for by the hpd gene, is used as a conjugate in the vaccine and may provide protection against ...
Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland

Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Erlendsdóttir, Helga; Hjálmarsdóttir, Martha Ásdís; van Tonder, Andries J.; Hrafnkelsson, Birgir; Sigurdsson, Samuel; Bentley, Stephen D.; Haraldsson, Ásgeir; Brueggemann, Angela B.; Kristinsson, Karl G. (American Society for Microbiology, 2018-09-26)

Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the serotypes, genetic lineages, and antimicrobial susceptibility of pneumococci isolated from ...
Genomic Analyses of >3,100 Nasopharyngeal Pneumococci Revealed Significant Differences Between Pneumococci Recovered in Four Different Geographical Regions

van Tonder, Andries J.; Bray, James E.; Jolley, Keith A.; Jansen van Rensburg, Melissa; Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Maiden, Martin; Bentley, Stephen D.; Haraldsson, Ásgeir; Erlendsdóttir, Helga; Kristinsson, Karl G.; Brueggemann, Angela B. (Frontiers Media SA, 2019-02-25)

Understanding the structure of a bacterial population is essential in order to understand bacterial evolution. Estimating the core genome (those genes common to all, or nearly all, strains of a species) is a key component of such analyses. The size and ...
Population Genomic Molecular Epidemiological Study of Macrolide-Resistant Streptococcus pyogenes in Iceland, 1995 to 2016: Identification of a Large Clonal Population with a pbp2x Mutation Conferring Reduced In Vitro β-Lactam Susceptibility

Southon, Sara B.; Beres, Stephen B.; Kachroo, Priyanka; Saavedra, Matthew Ojeda; Erlendsdóttir, Helga; Haraldsson, Gunnsteinn; Yerramilli, Prasanti; Pruitt, Layne; Zhu, Luchang; Musser, James M.; Kristinsson, Karl G. (American Society for Microbiology, 2020-06-10)

Resistance to macrolide antibiotics is a global concern in the treatment of Streptococcus pyogenes (group A Streptococcus [GAS]) infections. In Iceland, since the detection of the first macrolide-resistant isolate in 1998, three epidemic waves of ...

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