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Fletta eftir höfundi "Kricker, Jennifer"

Fletta eftir höfundi "Kricker, Jennifer"

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    Azithromycin ameliorates sulfur dioxide-induced airway epithelial damage and inflammatory responses 
    Jóelsson, Jón Pétur; Kricker, Jennifer; Arason, Ari Jon; Sigurdsson, Snaevar; Valdimarsdóttir, Bryndís; Garðarsson, Friðrik Rúnar; Page, Clive P.; Lehmann, Fredrik; Gudjonsson, Thorarinn; Ingthorsson, Saevar (Springer Science and Business Media LLC, 2020-09-10)
    Background: The airway epithelium (AE) forms the first line of defence against harmful particles and pathogens. Barrier failure of the airway epithelium contributes to exacerbations of a range of lung diseases that are commonly treated with Azithromycin ...
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    Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia 
    Arason, Ari Jon; Jóelsson, Jón Pétur; Valdimarsdóttir, Bryndís; Sigurdsson, Snaevar; Guðjónsson, Alexander; Halldorsson, Skarphedinn; Jóhannsson, Freyr; Rolfsson, Óttar; Lehmann, Fredrik; Ingthorsson, Saevar; Cherek, Paulina; Gudmundsson, Gudmundur H; Garðarsson, Friðrik R.; Page, Clive P.; Baldursson, Ólafur; Gudjonsson, Thorarinn; Kricker, Jennifer (Springer Science and Business Media LLC, 2019-06-24)
    BACKGROUND: Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity or other ...
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    Context-Dependent Function of Myoepithelial Cells in Breast Morphogenesis and Neoplasia 
    Ingþórsson, Sævar; Hilmarsdóttir, Bylgja; Kricker, Jennifer; Magnússon, Magnús Karl; Guðjónsson, Þórarinn (2015)
    Myoepithelial cells (MEPs) are specialized cells derived from epithelial progenitor cells, yet they also express the contractile machinery of smooth muscle cells. MEPs are prominent in glandular tissues where their function is to help expel secretions ...
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    Inhibition of PTP1B disrupts cell–cell adhesion and induces anoikis in breast epithelial cells 
    Hilmarsdóttir, Bylgja; Briem, Eiríkur; Halldórsson, Skarphéðinn; Kricker, Jennifer; Ingthorsson, Saevar; Gústafsdóttir, Sigrún; Mælandsmo, Gunhild M; Magnusson, Magnus Karl; Gudjonsson, Thorarinn (Springer Nature, 2017-05-11)
    Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as ...
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    Melflufen, a peptide‐conjugated alkylator, is an efficient anti‐neo‐plastic drug in breast cancer cell lines 
    Schepsky, Alexander; Traustadóttir, Gunnhildur Ásta; Jóelsson, Jón Pétur; Ingþórsson, Sævar; Kricker, Jennifer; Bergthorsson, Jon Thor; Ásbjarnarson, Árni; Gudjonsson, Thorkell; Nupponen, Nina; Slipicevic, Ana; Lehmann, Fredrik; Gudjonsson, Thorarinn (Wiley, 2020-07-27)
    Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide-conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells, where it is ...
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    MiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasin 
    Briem, Eiríkur; Budkova, Zuzana; Sigurðardóttir, Anna Karen; Hilmarsdóttir, Bylgja; Kricker, Jennifer; Timp, Winston; Magnusson, Magnus Karl; Traustadottir, Gunnhildur Asta; Gudjonsson, Thorarinn (Elsevier BV, 2019-02)
    MicroRNAs regulate developmental events such as branching morphogenesis, epithelial to mesenchymal transition (EMT) and its reverse process mesenchymal to epithelial transition (MET). In this study, we performed small RNA sequencing of a breast epithelial ...
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    Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model 
    Jóelsson, Jón Pétur; Ásbjarnarson, Árni; Sigurðsson, Snævar; Kricker, Jennifer; Valdimarsdottir, Bryndis; Thorarinsdottir, Holmfridur; Starradottir, Eir; Guðjónsson, Þórarinn; Ingþórsson, Sævar; Kárason, Sigurbergur (2022-07-22)
    BACKGROUND: Mechanical ventilation is a life-saving therapy for critically ill patients, providing rest to the respiratory muscles and facilitating gas exchange in the lungs. Ventilator-induced lung injury (VILI) is an unfortunate side effect of ...
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    YKL-40/CHI3L1 facilitates migration and invasion in HER2 overexpressing breast epithelial progenitor cells and generates a niche for capillary-like network formation 
    Morera, Erika; Steinhäuser, Sarah Sophie; Budkova, Zuzana; Ingthorsson, Saevar; Kricker, Jennifer; Krueger, Aileen; Traustadottir, Gunnhildur Asta; Gudjonsson, Thorarinn (Springer Science and Business Media LLC, 2019-09-03)
    Epithelial to mesenchymal transition (EMT) is a developmental event that is hijacked in some diseases such as fibrosis and cancer. In cancer, EMT has been linked to increased invasion and metastasis and is generally associated with a poor prognosis. ...