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Fletta eftir höfundi "Schmiegelow, Kjeld"

Fletta eftir höfundi "Schmiegelow, Kjeld"

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    Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia : phenotypes, risk factors and genotypes 
    Anastasopoulou, Stavroula; Nielsen, Rikke Linnemann; Als-Nielsen, Bodil; Banerjee, Joanna; Eriksson, Mats A.; Helenius, Marianne; Heyman, Mats M.; Johannsdottir, Inga Maria; Jónsson, Ólafur Gísli; MacGregor, Stuart; Mateos, Marion K.; Mayoh, Chelsea; Mikkel, Sirje; Myrberg, Ida Hed; Niinimäki, Riitta; Schmiegelow, Kjeld; Taskinen, Mervi; Vaitkeviciene, Goda; Warnqvist, Anna; Wolthers, Benjamin; Harila-Saari, Arja; Ranta, Susanna (2022-10)
    Central nervous system (CNS) toxicity is common at diagnosis and during treatment of pediatric acute lymphoblastic leukemia (ALL). We studied CNS toxicity in 1, 464 children aged 1.0-17.9 years, diagnosed with ALL and treated according to the Nordic ...
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    Changes in body mass index during treatment of childhood acute lymphoblastic leukemia with the Nordic ALL2008 protocol 
    Egnell, Christina; Närhinen, Hanna; Merker, Andrea; Jónsson, Ólafur Gísli; Lepik, Kristi; Niinimäki, Riitta; Schmiegelow, Kjeld; Stabell, Niklas; Klug Albertsen, Birgitte; Vaitkeviciene, Goda; Ranta, Susanna; Harila-Saari, Arja (2022-12)
    Objectives: Children with acute lymphoblastic leukemia (ALL) have a tendency to gain weight during treatment. As overweight and obesity associate with health problems, prophylactic interventions are warranted. Therefore, it is important to identify the ...
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    Characteristics of white blood cell count in acute lymphoblastic leukemia : A COST LEGEND phenotype-genotype study 
    Helenius, Marianne; Vaitkeviciene, Goda; Abrahamsson, Jonas; Jónsson, Ólafur Gisli; Lund, Bendik; Harila-Saari, Arja; Vettenranta, Kim; Mikkel, Sirje; Stanulla, Martin; Lopez-Lopez, Elixabet; Waanders, Esmé; Madsen, Hans O; Marquart, Hanne Vibeke; Modvig, Signe; Gupta, Ramneek; Schmiegelow, Kjeld; Nielsen, Rikke Linnemann (2022-03-22)
    Background: White blood cell count (WBC) as a measure of extramedullary leukemic cell survival is a well-known prognostic factor in acute lymphoblastic leukemia (ALL), but its biology, including impact of host genome variants, is poorly understood. ...
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    Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial 
    Norén-Nyström, Ulrika; Andersen, Mette K; Barbany, Gisela; Dirse, Vaidas; Eilert-Olsen, Martine; Engvall, Marie; Harila-Saari, Arja; Heyman, Mats; Hovland, Randi; Häikiö, Satu; Jónsson, Jón Jóhannes; Karhu, Ritva; Kjeldsen, Eigil; Norberg, Anna; Preiss, Birgitte S; Pulkkinen, Kati; Quist-Paulsen, Petter; Räsänen, Hannele; Schmiegelow, Kjeld; Seitsonen, Anne; Sjögren, Helene; Tammur, Pille; Johansson, Bertil (2023-05-04)
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    Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children 
    Mateos, Marion K.; Tulstrup, Morten; Quinn, Michael C.J.; Tuckuviene, Ruta; Marshall, Glenn M.; Gupta, Ramneek; Mayoh, Chelsea; Wolthers, Benjamin O.; Barbaro, Pasquale M.; Ruud, Ellen; Sutton, Rosemary; Huttunen, Pasi; Revesz, Tamas; Trakymiene, Sonata S.; Barbaric, Draga; Tedgård, Ulf; Giles, Jodie E.; Alvaro, Frank; Jonsson, Olafur G.; Mechinaud, Françoise; Saks, Kadri; Catchpoole, Daniel; Kotecha, Rishi S.; Dalla-Pozza, Luciano; Chenevix-Trench, Georgia; Trahair, Toby N.; Macgregor, Stuart; Schmiegelow, Kjeld (2020-05-19)
    Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied. Methods: We ...
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    Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia 
    Dam, Merete; Centanni, Maddalena; Friberg, Lena E.; Centanni, Daniel; Karlsson, Mats O.; Stensig Lynggaard, Line; Johannsdottir, Inga Maria; Wik, Hilde Skuterud; Malmros, Johan; Vaitkeviciene, Goda Elizabeta; Griskevicius, Laimonas; Hallböök, Helene; Jónsson, Ólafur Gísli; Overgaard, Ulrik; Schmiegelow, Kjeld; Hansen, Stefan Nygaard; Heyman, Mats; Albertsen, Birgitte Klug (2024)
    Asparaginase is an essential component of acute lymphoblastic leukemia (ALL) therapy, yet its associated toxicities often lead to treatment discontinuation, increasing the risk of relapse. Hypersensitivity reactions include clinical allergies, silent ...
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    Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia 
    Krali, Olga; Marincevic-Zuniga, Yanara; Arvidsson, Gustav; Enblad, Anna Pia; Lundmark, Anders; Sayyab, Shumaila; Zachariadis, Vasilios; Heinäniemi, Merja; Suhonen, Janne; Oksa, Laura; Vepsäläinen, Kaisa; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Lilljebjörn, Henrik; Fioretos, Thoas; Madsen, Hans O.; Marquart, Hanne Vibeke; Flaegstad, Trond; Forestier, Erik; Jónsson, Ólafur Gísli; Kanerva, Jukka; Lohi, Olli; Norén-Nyström, Ulrika; Schmiegelow, Kjeld; Harila, Arja; Heyman, Mats; Lönnerholm, Gudmar; Syvänen, Ann Christine; Nordlund, Jessica (2023-12)
    Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to ...
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    Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia. 
    Egnell, Christina; Heyman, Mats; Jónsson, Ólafur Gísli; Raja, Raheel A; Niinimäki, Riitta; Albertsen, Birgitte Klug; Schmiegelow, Kjeld; Stabell, Niklas; Vaitkeviciene, Goda; Lepik, Kristi; Harila-Saari, Arja; Ranta, Susanna (2022-03)
    Obesity is associated with poor outcomes in childhood acute lymphoblastic leukaemia (ALL). We explored whether severe treatment-related toxicity and treatment delays could explain this observation. This study included 1 443 children aged 2·0-17·9 years ...
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    Thiopurine Enhanced ALL Maintenance (TEAM) : study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol 
    Toksvang, Linea Natalie; Als-Nielsen, Bodil; Bacon, Christopher; Bertasiute, Ruta; Duarte, Ximo; Escherich, Gabriele; Helgadóttir, Elín Anna; Johannsdottir, Inga Rinvoll; Jónsson, Ólafur Gísli; Kozlowski, Piotr; Langenskjöld, Cecilia; Lepik, Kristi; Niinimäki, Riitta; Overgaard, Ulrik Malthe; Punab, Mari; Räty, Riikka; Segers, Heidi; van der Sluis, Inge; Smith, Owen Patrick; Strullu, Marion; Vaitkevičienė, Goda; Wik, Hilde Skuterud; Heyman, Mats; Schmiegelow, Kjeld (2022-05-02)
    Background: A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse. The year-long maintenance phase is essential ...