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Browsing by Author "Jónsson, Ólafur Gísli"

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Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia : phenotypes, risk factors and genotypes

Anastasopoulou, Stavroula; Nielsen, Rikke Linnemann; Als-Nielsen, Bodil; Banerjee, Joanna; Eriksson, Mats A.; Helenius, Marianne; Heyman, Mats M.; Johannsdottir, Inga Maria; Jónsson, Ólafur Gísli; MacGregor, Stuart; Mateos, Marion K.; Mayoh, Chelsea; Mikkel, Sirje; Myrberg, Ida Hed; Niinimäki, Riitta; Schmiegelow, Kjeld; Taskinen, Mervi; Vaitkeviciene, Goda; Warnqvist, Anna; Wolthers, Benjamin; Harila-Saari, Arja; Ranta, Susanna (2022-10)

Central nervous system (CNS) toxicity is common at diagnosis and during treatment of pediatric acute lymphoblastic leukemia (ALL). We studied CNS toxicity in 1, 464 children aged 1.0-17.9 years, diagnosed with ALL and treated according to the Nordic ...
Changes in body mass index during treatment of childhood acute lymphoblastic leukemia with the Nordic ALL2008 protocol

Egnell, Christina; Närhinen, Hanna; Merker, Andrea; Jónsson, Ólafur Gísli; Lepik, Kristi; Niinimäki, Riitta; Schmiegelow, Kjeld; Stabell, Niklas; Klug Albertsen, Birgitte; Vaitkeviciene, Goda; Ranta, Susanna; Harila-Saari, Arja (2022-12)

Objectives: Children with acute lymphoblastic leukemia (ALL) have a tendency to gain weight during treatment. As overweight and obesity associate with health problems, prophylactic interventions are warranted. Therefore, it is important to identify the ...
Fusion transcript analysis reveals slower response kinetics than multiparameter flow cytometry in childhood acute myeloid leukaemia

Karlsson, Lene; Nyvold, Charlotte Guldborg; Soboli, Anastasia; Johansson, Pegah; Palmqvist, Lars; Tierens, Anne; Hasle, Henrik; Lausen, Birgitte; Jónsson, Ólafur Gísli; Jürgensen, Gitte Wulff; Ebbesen, Lene Hyldahl; Abrahamsson, Jonas; Fogelstrand, Linda (2022-12)

Introduction: Analysis of measurable residual disease (MRD) is increasingly being implemented in the clinical care of children and adults with acute myeloid leukaemia (AML). However, MRD methodologies differ and discordances in results lead to difficulties ...
Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia

Dam, Merete; Centanni, Maddalena; Friberg, Lena E.; Centanni, Daniel; Karlsson, Mats O.; Stensig Lynggaard, Line; Johannsdottir, Inga Maria; Wik, Hilde Skuterud; Malmros, Johan; Vaitkeviciene, Goda Elizabeta; Griskevicius, Laimonas; Hallböök, Helene; Jónsson, Ólafur Gísli; Overgaard, Ulrik; Schmiegelow, Kjeld; Hansen, Stefan Nygaard; Heyman, Mats; Albertsen, Birgitte Klug (2024)

Asparaginase is an essential component of acute lymphoblastic leukemia (ALL) therapy, yet its associated toxicities often lead to treatment discontinuation, increasing the risk of relapse. Hypersensitivity reactions include clinical allergies, silent ...
Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia

Krali, Olga; Marincevic-Zuniga, Yanara; Arvidsson, Gustav; Enblad, Anna Pia; Lundmark, Anders; Sayyab, Shumaila; Zachariadis, Vasilios; Heinäniemi, Merja; Suhonen, Janne; Oksa, Laura; Vepsäläinen, Kaisa; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Lilljebjörn, Henrik; Fioretos, Thoas; Madsen, Hans O.; Marquart, Hanne Vibeke; Flaegstad, Trond; Forestier, Erik; Jónsson, Ólafur Gísli; Kanerva, Jukka; Lohi, Olli; Norén-Nyström, Ulrika; Schmiegelow, Kjeld; Harila, Arja; Heyman, Mats; Lönnerholm, Gudmar; Syvänen, Ann Christine; Nordlund, Jessica (2023-12)

Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to ...
Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia.

Egnell, Christina; Heyman, Mats; Jónsson, Ólafur Gísli; Raja, Raheel A; Niinimäki, Riitta; Albertsen, Birgitte Klug; Schmiegelow, Kjeld; Stabell, Niklas; Vaitkeviciene, Goda; Lepik, Kristi; Harila-Saari, Arja; Ranta, Susanna (2022-03)

Obesity is associated with poor outcomes in childhood acute lymphoblastic leukaemia (ALL). We explored whether severe treatment-related toxicity and treatment delays could explain this observation. This study included 1 443 children aged 2·0-17·9 years ...
Sequelae and post-thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol

Dam, Merete; Lynggaard, Line Stensig; Jónsson, Ólafur Gísli; Saulyte Trakymiene, Sonata; Palk, Katrin; Jarvis, Kirsten; Andrés-Jensen, Liv; Tuckuviene, Ruta; Albertsen, Birgitte Klug (2024-06)

The treatment of acute lymphoblastic leukemia (ALL) is frequently complicated by toxicity, including venous thromboembolism (VTE) affecting roughly 8% of patients. VTE can lead to post-thrombotic syndrome (PTS), a group of signs and symptoms developed ...
Thiopurine Enhanced ALL Maintenance (TEAM) : study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol

Toksvang, Linea Natalie; Als-Nielsen, Bodil; Bacon, Christopher; Bertasiute, Ruta; Duarte, Ximo; Escherich, Gabriele; Helgadóttir, Elín Anna; Johannsdottir, Inga Rinvoll; Jónsson, Ólafur Gísli; Kozlowski, Piotr; Langenskjöld, Cecilia; Lepik, Kristi; Niinimäki, Riitta; Overgaard, Ulrik Malthe; Punab, Mari; Räty, Riikka; Segers, Heidi; van der Sluis, Inge; Smith, Owen Patrick; Strullu, Marion; Vaitkevičienė, Goda; Wik, Hilde Skuterud; Heyman, Mats; Schmiegelow, Kjeld (2022-05-02)

Background: A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse. The year-long maintenance phase is essential ...

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