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Browsing by Author "Kamble, Nilesh Ramesh"

Browsing by Author "Kamble, Nilesh Ramesh"

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    High-resolution EPR distance measurements on RNA and DNA with the non-covalent Ǵ spin label 
    Heinz, Marcel; Erlenbach, Nicole; Stelzl, Lukas S; Thierolf, Grace; Kamble, Nilesh Ramesh; Sigurdsson, Snorri; Prisner, Thomas F.; Hummer, Gerhard (Oxford University Press (OUP), 2019-11-28)
    Pulsed electron paramagnetic resonance (EPR) experiments, among them most prominently pulsed electron-electron double resonance experiments (PELDOR/DEER), resolve the conformational dynamics of nucleic acids with high resolution. The wide application ...
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    Noncovalent and site-directed spin labeling of duplex RNA 
    Kamble, Nilesh Ramesh; Gränz, Markus; Prisner, Thomas F.; Sigurdsson, Snorri (Royal Society of Chemistry (RSC), 2016)
    An isoindoline-nitroxide derivative of guanine (G, "G-spin") was shown to bind specifically and effectively to abasic sites in duplex RNAs. Distance measurements on a G-labeled duplex RNA with PELDOR (DEER) showed a strong orientation dependence. Thus, ...
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    Noncovalent Spin‐Labeling of DNA and RNA Triplexes 
    Kamble, Nilesh Ramesh; Wolfrum, Manpreet; Halbritter, Thomas; Sigurdsson, Snorri; Richert, Clemens (Wiley, 2020-01-21)
    Studying nucleic acids often requires labeling. Many labeling approaches require covalent bonds between the nucleic acid and the label, which complicates experimental procedures. Noncovalent labeling avoids the need for highly specific reagents and ...
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    Purine-derived nitroxides for noncovalent spin labeling of abasic sites in duplex nucleic acids 
    Kamble, Nilesh Ramesh (University of Iceland, School of Engineering and Natural Sciences, Faculty of Physical Sciences, 2017-12-21)
    Electron paramagnetic resonance (EPR) spectroscopy is a well known technique that is routinely used to investigate the structure and dynamics of nucleic acids. EPR requires incorporation of paramagnetic centers at specific sites, called site-directed ...