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Fletta eftir höfundi "Hansen, Kasper D."

Fletta eftir höfundi "Hansen, Kasper D."

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    Coexpression patterns define epigenetic regulators associated with neurological dysfunction 
    Boukas, Leandros; Havrilla, James M.; Hickey, Peter F.; Quinlan, Aaron R.; Bjornsson, Hans; Hansen, Kasper D. (Cold Spring Harbor Laboratory, 2019-03-11)
    Coding variants in epigenetic regulators are emerging as causes of neurological dysfunction and cancer. However, a comprehensive effort to identify disease candidates within the human epigenetic machinery (EM) has not been performed; it is unclear ...
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    A mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibition 
    Gao, Christine W.; Lin, Wan Ying; Riddle, Ryan C.; Kushwaha, Priyanka; Boukas, Leandros; Björnsson, Hans Tómas; Hansen, Kasper D.; Fahrner, Jill A. (2024-01-09)
    Weaver syndrome is a Mendelian disorder of the epigenetic machinery (MDEM) caused by germline pathogenic variants in EZH2, which encodes the predominant H3K27 methyltransferase and key enzymatic component of Polycomb repressive complex 2 (PRC2). Weaver ...
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    Universal prediction of cell-cycle position using transfer learning 
    Zheng, Shijie C.; Stein-O’Brien, Genevieve; Augustin, Jonathan J.; Slosberg, Jared; Carosso, Giovanni A.; Winer, Briana; Shin, Gloria; Björnsson, Hans Tómas; Goff, Loyal A.; Hansen, Kasper D. (2022-01-31)
    Background: The cell cycle is a highly conserved, continuous process which controls faithful replication and division of cells. Single-cell technologies have enabled increasingly precise measurements of the cell cycle both as a biological process of ...