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    Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer 
    Ferreira, Manuel A.; Arason, Adalgeir (Springer Science and Business Media LLC, 2019-04-15)
    Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and ...
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    Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank 
    Ólafsdóttir, Thorhildur; Thorleifsson, Gudmar; sulem, patrick; Stefánsson, Ólafur A.; Medek, Helga; Olafsson, Karl; Ingþórsson, Orri; Guðmundsson, Valur; Jonsdottir, Ingileif; Halldorsson, Gisli; Kristjansson, Ragnar; Frigge, Michael L.; Stefánsdóttir, Lilja; Sigurðsson, Jón K.; Oddsson, Asmundur; Sigurðsson, Ásgeir; Eggertsson, Hannes P.; Melsted, Páll; Halldórsson, Bjarni; Lund, Sigrún Helga; Styrkarsdottir, Unnur; Steinthorsdottir, Valgerdur; Gudmundsson, Julius; Holm, Hilma; Tragante do O, Vinicius; Asselbergs, Folkert; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; Jónsdóttir, Kristín; Rafnar, Thorunn; Stefansson, Kari (Springer Science and Business Media LLC, 2020-03-17)
    Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We performed a genome-wide association study of POP using data from Iceland and the UK Biobank, a total ...
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    Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria 
    Teumer, Alexander; Li, Yong; Ghasemi, Sahar; Prins, Bram P.; Wuttke, Matthias; Hermle, Tobias; Giri, Ayush; Sieber, Karsten B.; Qiu, Chengxiang; Kirsten, Holger; Tin, Adrienne; Chu, Audrey Y.; Bansal, Nisha; Feitosa, Mary F.; Wang, Lihua; Chai, Jin-Fang; Cocca, Massimiliano; Fuchsberger, Christian; Gorski, Mathias; Hoppmann, Anselm; Horn, Katrin; Li, Man; Marten, Jonathan; Noce, Damia; Nutile, Teresa; Sedaghat, Sanaz; Sveinbjornsson, Gardar; Tayo, Bamidele O.; van der Most, Peter J.; Xu, Yizhe; Yu, Zhi; Gerstner, Lea; Ärnlöv, Johan; Bakker, Stephan J. L.; Baptista, Daniela; Biggs, Mary L.; Boerwinkle, Eric; Brenner, Hermann; Burkhardt, Ralph; Carroll, Robert J.; Chee, Miao-Li; Chee, Miao-Ling; Chen, Mengmeng; Cheng, Ching-Yu; Cook, James P.; Coresh, Josef; Corre, Tanguy; Danesh, John; de Borst, Martin H.; De Grandi, Alessandro; de Mutsert, Renée; de Vries, Aiko P. J.; Degenhardt, Frauke; Dittrich, Katalin; Divers, Jasmin; Eckardt, Kai-Uwe; Ehret, Georg; Endlich, Karlhans; Felix, Janine F.; Franco, Oscar H.; Franke, Andre; Freedman, Barry I.; Freitag-Wolf, Sandra; Gansevoort, Ron T.; Giedraitis, Vilmantas; Gögele, Martin; Grundner-Culemann, Franziska; Gudbjartsson, Daniel; Gudnason, Vilmundur; Hamet, Pavel; Harris, Tamara B.; Hicks, Andrew A.; Holm, Hilma; Foo, Valencia Hui Xian; Hwang, Shih-Jen; Ikram, M. Arfan; Ingelsson, Erik; Jaddoe, Vincent W. V.; Jakobsdottir, Johanna; Josyula, Navya Shilpa; Jung, Bettina; Kähönen, Mika; Khor, Chiea-Chuen; Kiess, Wieland; Koenig, Wolfgang; Körner, Antje; Kovacs, Peter; Kramer, Holly; Krämer, Bernhard K.; Kronenberg, Florian; Lange, Leslie A.; Langefeld, Carl D.; Lee, Jeannette Jen-Mai; Lehtimäki, Terho; Lieb, Wolfgang; Lim, Su-Chi; Lind, Lars; Lindgren, Cecilia M.; Liu, Jianjun; Loeffler, Markus; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Maranville, Joseph C.; Mascalzoni, Deborah; McMullen, Barbara; Meisinger, Christa; Meitinger, Thomas; Miliku, Kozeta; Mook-Kanamori, Dennis O.; Müller-Nurasyid, Martina; Mychaleckyj, Josyf C.; Nauck, Matthias; Nikus, Kjell; Ning, Boting; Noordam, Raymond; Connell, Jeffrey O’; Olafsson, Isleifur; Palmer, Nicholette D.; Peters, Annette; Podgornaia, Anna I.; Ponte, Belen; Poulain, Tanja; Pramstaller, Peter P.; Rabelink, Ton J.; Raffield, Laura M.; Reilly, Dermot F.; Rettig, Rainer; Rheinberger, Myriam; Rice, Kenneth M.; Rivadeneira, Fernando; Runz, Heiko; Ryan, Kathleen A.; Sabanayagam, Charumathi; Saum, Kai-Uwe; Schöttker, Ben; Shaffer, Christian M.; Shi, Yuan; Smith, Albert Vernon; Strauch, Konstantin; Stumvoll, Michael; Sun, Benjamin B.; Szymczak, Silke; Tai, E-Shyong; Tan, Nicholas Y. Q.; Taylor, Kent D.; Teren, Andrej; Tham, Yih-Chung; Thiery, Joachim; Thio, Chris H. L.; Thomsen, Hauke; Thorsteinsdottir, Unnur; Tönjes, Anke; Tremblay, Johanne; Uitterlinden, André G.; van der Harst, Pim; Verweij, Niek; Vogelezang, Suzanne; Völker, Uwe; Waldenberger, Melanie; Wang, Chaolong; Wilson, Otis D.; Wong, Charlene; Wong, Tien-Yin; Yang, Qiong; Yasuda, Masayuki; Akilesh, Shreeram; Bochud, Murielle; Böger, Carsten A.; Devuyst, Olivier; Edwards, Todd L.; Ho, Kevin; Morris, Andrew P.; Parsa, Afshin; Pendergrass, Sarah A.; Psaty, Bruce M.; Rotter, Jerome I.; Stefansson, Kari; Wilson, James G.; Susztak, Katalin; Snieder, Harold; Heid, Iris M.; Scholz, Markus; Butterworth, Adam S.; Hung, Adriana M.; Pattaro, Cristian; Köttgen, Anna (Springer Science and Business Media LLC, 2019-09-11)
    Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) ...
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    Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria 
    Teumer, Alexander; Li, Yong; Ghasemi, Sahar; Prins, Bram P.; Wuttke, Matthias; Hermle, Tobias; Giri, Ayush; Sieber, Karsten B.; Qiu, Chengxiang; Kirsten, Holger; Tin, Adrienne; Chu, Audrey Y.; Bansal, Nisha; Feitosa, Mary F.; Wang, Lihua; Chai, Jin Fang; Cocca, Massimiliano; Fuchsberger, Christian; Gorski, Mathias; Hoppmann, Anselm; Horn, Katrin; Li, Man; Marten, Jonathan; Noce, Damia; Nutile, Teresa; Sedaghat, Sanaz; Sveinbjornsson, Gardar; Tayo, Bamidele O.; van der Most, Peter J.; Xu, Yizhe; Yu, Zhi; Gerstner, Lea; Ärnlöv, Johan; Bakker, Stephan J.L.; Baptista, Daniela; Biggs, Mary L.; Boerwinkle, Eric; Brenner, Hermann; Burkhardt, Ralph; Carroll, Robert J.; Chee, Miao Li; Chee, Miao Ling; Chen, Mengmeng; Cheng, Ching Yu; Cook, James P.; Coresh, Josef; Corre, Tanguy; Danesh, John; de Borst, Martin H.; De Grandi, Alessandro; de Mutsert, Renée; de Vries, Aiko P.J.; Degenhardt, Frauke; Dittrich, Katalin; Divers, Jasmin; Eckardt, Kai Uwe; Ehret, Georg; Endlich, Karlhans; Felix, Janine F.; Franco, Oscar H.; Franke, Andre; Freedman, Barry I.; Freitag-Wolf, Sandra; Gansevoort, Ron T.; Giedraitis, Vilmantas; Gögele, Martin; Grundner-Culemann, Franziska; Gudbjartsson, Daniel F.; Gudnason, Vilmundur; Hamet, Pavel; Harris, Tamara B.; Hicks, Andrew A.; Holm, Hilma; Foo, Valencia Hui Xian; Hwang, Shih Jen; Ikram, M. Arfan; Ingelsson, Erik; Jaddoe, Vincent W.V.; Jakobsdottir, Johanna; Josyula, Navya Shilpa; Jung, Bettina; Kähönen, Mika; Khor, Chiea Chuen; Kiess, Wieland; Koenig, Wolfgang; Körner, Antje; Kovacs, Peter; Kramer, Holly; Krämer, Bernhard K.; Kronenberg, Florian; Lange, Leslie A.; Langefeld, Carl D.; Lee, Jeannette Jen Mai; Lehtimäki, Terho; Lieb, Wolfgang; Lim, Su Chi; Lind, Lars; Lindgren, Cecilia M.; Liu, Jianjun; Loeffler, Markus; Lyytikäinen, Leo Pekka; Mahajan, Anubha; Maranville, Joseph C.; Mascalzoni, Deborah; McMullen, Barbara; Meisinger, Christa; Meitinger, Thomas; Miliku, Kozeta; Mook-Kanamori, Dennis O.; Müller-Nurasyid, Martina; Mychaleckyj, Josyf C.; Nauck, Matthias; Nikus, Kjell; Ning, Boting; Noordam, Raymond; Connell, Jeffrey O’; Olafsson, Isleifur; Palmer, Nicholette D.; Peters, Annette; Podgornaia, Anna I.; Ponte, Belen; Poulain, Tanja; Pramstaller, Peter P.; Rabelink, Ton J.; Raffield, Laura M.; Reilly, Dermot F.; Rettig, Rainer; Rheinberger, Myriam; Rice, Kenneth M.; Rivadeneira, Fernando; Runz, Heiko; Ryan, Kathleen A.; Sabanayagam, Charumathi; Saum, Kai Uwe; Schöttker, Ben; Shaffer, Christian M.; Shi, Yuan; Smith, Albert V.; Strauch, Konstantin; Stumvoll, Michael; Sun, Benjamin B.; Szymczak, Silke; Tai, E. Shyong; Tan, Nicholas Y.Q.; Taylor, Kent D.; Teren, Andrej; Tham, Yih Chung; Thiery, Joachim; Thio, Chris H.L.; Thomsen, Hauke; Thorsteinsdottir, Unnur; Tönjes, Anke; Tremblay, Johanne; Uitterlinden, André G.; van der Harst, Pim; Verweij, Niek; Vogelezang, Suzanne; Völker, Uwe; Waldenberger, Melanie; Wang, Chaolong; Wilson, Otis D.; Wong, Charlene; Wong, Tien Yin; Yang, Qiong; Yasuda, Masayuki; Akilesh, Shreeram; Bochud, Murielle; Böger, Carsten A.; Devuyst, Olivier; Edwards, Todd L.; Ho, Kevin; Morris, Andrew P.; Parsa, Afshin; Pendergrass, Sarah A.; Psaty, Bruce M.; Rotter, Jerome I.; Stefansson, Kari; Wilson, James G.; Susztak, Katalin; Snieder, Harold; Heid, Iris M.; Scholz, Markus; Butterworth, Adam S.; Hung, Adriana M.; Pattaro, Cristian; Köttgen, Anna (2019-12-01)
    Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) ...
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    Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits 
    van Setten, Jessica; Verweij, Niek; Mbarek, Hamdi; Niemeijer, Maartje N.; Trompet, Stella; Arking, Dan E.; Brody, Jennifer A.; Gandin, Ilaria; Grarup, Niels; Hall, Leanne M.; Hemerich, Daiane; Lyytikäinen, Leo-Pekka; Mei, Hao; Müller-Nurasyid, Martina; Prins, Bram P.; Robino, Antonietta; Smith, Albert Vernon; Warren, Helen R.; Asselbergs, Folkert W.; Boomsma, Dorret I.; Caulfield, Mark J.; Eijgelsheim, Mark; Ford, Ian; Hansen, Torben; Harris, Tamara B.; Heckbert, Susan R.; Hottenga, Jouke-Jan; Iorio, Annamaria; Kors, Jan A.; Linneberg, Allan; MacFarlane, Peter W.; Meitinger, Thomas; Nelson, Christopher P.; Raitakari, Olli T.; Silva Aldana, Claudia T.; Sinagra, Gianfranco; Sinner, Moritz; Soliman, Elsayed Z.; Stoll, Monika; Uitterlinden, Andre; van Duijn, Cornelia M.; Waldenberger, Melanie; Alonso, Alvaro; Gasparini, Paolo; Gudnason, Vilmundur; Jamshidi, Yalda; Kääb, Stefan; Kanters, Jørgen K.; Lehtimäki, Terho; Munroe, Patricia B.; Peters, Annette; Samani, Nilesh J.; Sotoodehnia, Nona; Ulivi, Sheila; Wilson, James G.; de Geus, Eco J. C.; Jukema, J. Wouter; Stricker, Bruno; van der Harst, Pim; de Bakker, Paul I. W.; Isaacs, Aaron (Springer Science and Business Media LLC, 2019-01-24)
    Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR interval). In the current study, ...
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    Genome-wide association meta-analysis of single-nucleotide polymorphisms and symptomatic venous thromboembolism during therapy for acute lymphoblastic leukemia and lymphoma in caucasian children 
    Mateos, Marion K.; Tulstrup, Morten; Quinn, Michael C.J.; Tuckuviene, Ruta; Marshall, Glenn M.; Gupta, Ramneek; Mayoh, Chelsea; Wolthers, Benjamin O.; Barbaro, Pasquale M.; Ruud, Ellen; Sutton, Rosemary; Huttunen, Pasi; Revesz, Tamas; Trakymiene, Sonata S.; Barbaric, Draga; Tedgård, Ulf; Giles, Jodie E.; Alvaro, Frank; Jonsson, Olafur G.; Mechinaud, Françoise; Saks, Kadri; Catchpoole, Daniel; Kotecha, Rishi S.; Dalla-Pozza, Luciano; Chenevix-Trench, Georgia; Trahair, Toby N.; Macgregor, Stuart; Schmiegelow, Kjeld (2020-05-19)
    Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied. Methods: We ...
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    Genome-wide association meta-analysis yields 20 loci associated with gallstone disease 
    Ferkingstad, Egil; Oddsson, Asmundur; Gretarsdottir, Solveig; Benonisdottir, Stefania; Thorleifsson, Gudmar; Deaton, Aimee M.; Jónsson, Stefán; Stefánsson, Ólafur A.; Norðdahl, Guðmundur L.; Zink, Florian; Arnadottir, Gudny; Gunnarsson, Bjarni; Halldorsson, Gisli; Helgadottir, Anna; Jensson, Brynjar Örn; Kristjánsson, Ragnar P.; Sveinbjornsson, Gardar; Sverrisson, Davíð A.; Másson, Gísli; Olafsson, Isleifur; Eyjólfsson, Guðmundur I.; Sigurðardóttir, Ólöf; Holm, Hilma; Jonsdottir, Ingileif; Ólafsson, Sigurður; Steingrimsdottir, Thora; Rafnar, Thorunn; Björnsson, Einar Stefán; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel; sulem, patrick; Stefansson, Kari (Springer Science and Business Media LLC, 2018-11-30)
    Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genomewide association studies of gallstone disease in Iceland and the UK, totaling ...
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    A genome-wide association study identifies genetic loci associated with specific lobar brain volumes 
    van der Lee, Sven J.; Knol, Maria J.; Chauhan, Ganesh; Satizabal, Claudia L.; Smith, Albert Vernon; Hofer, Edith; Bis, Joshua C.; Hibar, Derrek P.; Hilal, Saima; van den Akker, Erik B.; Arfanakis, Konstantinos; Bernard, Manon; Yanek, Lisa R.; Amin, Najaf; Crivello, Fabrice; Cheung, Josh W.; Harris, Tamara B.; Saba, Yasaman; Lopez, Oscar L.; Li, Shuo; van der Grond, Jeroen; Yu, Lei; Paus, Tomas; Roshchupkin, Gennady V.; Amouyel, Philippe; Jahanshad, Neda; Taylor, Kent D.; Yang, Qiong; Mathias, Rasika A.; Boehringer, Stefan; Mazoyer, Bernard; Rice, Ken; Cheng, Ching Yu; Maillard, Pauline; van Heemst, Diana; Wong, Tien Yin; Niessen, Wiro J.; Beiser, Alexa S.; Beekman, Marian; Zhao, Wanting; Nyquist, Paul A.; Chen, Christopher; Launer, Lenore J.; Psaty, Bruce M.; Ikram, M. Kamran; Vernooij, Meike W.; Schmidt, Helena; Pausova, Zdenka; Becker, Diane M.; De Jager, Philip L.; Thompson, Paul M.; van Duijn, Cornelia M.; Bennett, David A.; Slagboom, P. Eline; Schmidt, Reinhold; Longstreth, W. T.; Ikram, M. Arfan; Seshadri, Sudha; Debette, Stéphanie; Gudnason, Vilmundur; Adams, Hieab H. H.; DeCarli, Charles (Springer Science and Business Media LLC, 2019-08-02)
    Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We ...
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    Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity 
    Mbarek, Hamdi; Gordon, Scott D.; Duffy, David L.; Hubers, Nikki; Mortlock, Sally; Beck, Jeffrey J.; Hottenga, Jouke Jan; Pool, René; Dolan, Conor V.; Actkins, Ky'Era V.; Gerring, Zachary F.; Van Dongen, Jenny; Ehli, Erik A.; Iacono, William G.; Mcgue, Matt; Chasman, Daniel I.; Gallagher, C. Scott; Schilit, Samantha L.P.; Morton, Cynthia C.; Paré, Guillaume; Willemsen, Gonneke; Whiteman, David C.; Olsen, Catherine M.; Derom, Catherine; Vlietinck, Robert; Gudbjartsson, Daniel; Cannon-Albright, Lisa; Krapohl, Eva; Plomin, Robert; Magnusson, Patrik K.E.; Pedersen, Nancy L.; Hysi, Pirro; Mangino, Massimo; Spector, Timothy D.; Palviainen, Teemu; Milaneschi, Yuri; Penninnx, Brenda W.; Campos, Adrian I.; Ong, Ken K.; Perry, John R.B.; Lambalk, Cornelis B.; Kaprio, Jaakko; Ólafsson, Ísleifur; Duroure, Karine; Revenu, Céline; Rentería, Miguel E.; Yengo, Loic; Davis, Lea; Derks, Eske M.; Medland, Sarah E.; Stefansson, Hreinn; Stefánsson, Kári; Del Bene, Filippo; Reversade, Bruno; Montgomery, Grant W.; Boomsma, Dorret I.; Martin, Nicholas G. (2024-01-01)
    STUDY QUESTION: Which genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins? SUMMARY ANSWER: We identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB and SMAD3. ...
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    Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume 
    Vojinovic, Dina; Adams, Hieab H.; Jian, Xueqiu; Yang, Qiong; Smith, Albert Vernon; Bis, Joshua C.; Teumer, Alexander; Scholz, Markus; Armstrong, Nicola J.; Hofer, Edith; Saba, Yasaman; Luciano, Michelle; Bernard, Manon; Trompet, Stella; Yang, Jingyun; Gillespie, Nathan A.; van der Lee, Sven J.; Neumann, Alexander; Ahmad, Shahzad; Andreassen, Ole A.; Ames, David; Amin, Najaf; Arfanakis, Konstantinos; Bastin, Mark E.; Becker, Diane M.; Beiser, Alexa S.; Beyer, Frauke; Brodaty, Henry; Bryan, R. Nick; Bülow, Robin; Dale, Anders M.; De Jager, Philip L.; Deary, Ian J.; DeCarli, Charles; Fleischman, Debra A.; Gottesman, Rebecca F.; van der Grond, Jeroen; Gudnason, Vilmundur; Harris, Tamara B.; Homuth, Georg; Knopman, David S.; Kwok, John B.; Lewis, Cora E.; Li, Shuo; Loeffler, Markus; Lopez, Oscar L.; Maillard, Pauline; El Marroun, Hanan; Mather, Karen A.; Mosley, Thomas H.; Muetzel, Ryan L.; Nauck, Matthias; Nyquist, Paul A.; Panizzon, Matthew S.; Pausova, Zdenka; Psaty, Bruce M.; Rice, Ken; Rotter, Jerome I.; Royle, Natalie; Satizabal, Claudia L.; Schmidt, Reinhold; Schofield, Peter R.; Schreiner, Pamela J.; Sidney, Stephen; Stott, David J.; Thalamuthu, Anbupalam; Uitterlinden, Andre G.; Valdés Hernández, Maria C.; Vernooij, Meike W.; Wen, Wei; White, Tonya; Witte, A. Veronica; Wittfeld, Katharina; Wright, Margaret J.; Yanek, Lisa R.; Tiemeier, Henning; Kremen, William S.; Bennett, David A.; Jukema, J. Wouter; Paus, Tomas; Wardlaw, Joanna M.; Schmidt, Helena; Sachdev, Perminder S.; Villringer, Arno; Grabe, Hans Jörgen; Longstreth, W T; van Duijn, Cornelia M.; Launer, Lenore J.; Seshadri, Sudha; Ikram, M Arfan; Fornage, Myriam (Springer Science and Business Media LLC, 2018-09-26)
    The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic ...
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    Genome-wide association study of circulating interleukin 6 levels identifies novel loci 
    Ahluwalia, Tarunveer S.; Prins, Bram P.; Abdollahi, Mohammadreza; Armstrong, Nicola J.; Aslibekyan, Stella; Bain, Lisa; Jefferis, Barbara; Baumert, Jens; Beekman, Marian; Ben-Shlomo, Yoav; Bis, Joshua C.; Mitchell, Braxton D.; De Geus, Eco; Delgado, Graciela E.; Marek, Diana; Eriksson, Joel; Kajantie, Eero; Kanoni, Stavroula; Kemp, John P.; Lu, Chen; Marioni, Riccardo E.; McLachlan, Stela; Milaneschi, Yuri; Nolte, Ilja M.; Petrelis, Alexandros M.; Porcu, Eleonora; Sabater-Lleal, Maria; Naderi, Elnaz; Seppälä, Ilkka; Shah, Tina; Singhal, Gaurav; Standl, Marie; Teumer, Alexander; Thalamuthu, Anbupalam; Thiering, Elisabeth; Trompet, Stella; Ballantyne, Christie M.; Benjamin, Emelia J.; Casas, Juan P.; Toben, Catherine; Dedoussis, George; Deelen, Joris; Durda, Peter; Engmann, Jorgen; Feitosa, Mary F.; Grallert, Harald; Hammarstedt, Ann; Harris, Sarah E.; Homuth, Georg; Guðnason, Vilmundur G. (2021-01-30)
    Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease ...
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    Genome-wide association study of posttraumatic stress disorder among childhood cancer survivors : results from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort 
    Lu, Donghao; Sapkota, Yadav; Valdimarsdóttir, Unnur A.; Koenen, Karestan C.; Li, Nan; Leisenring, Wendy M.; Gibson, Todd; Wilson, Carmen L.; Robison, Leslie L.; Hudson, Melissa M.; Armstrong, Gregory T.; Krull, Kevin R.; Yasui, Yutaka; Bhatia, Smita; Recklitis, Christopher J. (2022-08-23)
    Genetic influence shapes who develops posttraumatic stress disorder (PTSD) after traumatic events. However, the genetic variants identified for PTSD may in fact be associated with traumatic exposures (e.g., interpersonal violence), which appear heritable ...
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    Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis 
    Allen, Richard J.; Guillen-Guio, Beatriz; Oldham, Justin M.; Ma, Shwu-Fan; Dressen, Amy; Paynton, Megan L.; Kraven, Luke M.; Obeidat, Ma'en; Li, Xuan; Ng, Michael; Braybrooke, Rebecca; Molina-Molina, Maria; Hobbs, Brian D.; Putman, Rachel K.; Sakornsakolpat, Phuwanat; Booth, Helen L.; Fahy, William A.; Hart, Simon P.; Hill, Mike R.; Hirani, Nik; Hubbard, Richard B.; McAnulty, Robin J.; Millar, Ann B.; Navaratnam, Vidyia; Oballa, Eunice; Parfrey, Helen; Saini, Gauri; Whyte, Moira K. B.; Zhang, Yingze; Kaminski, Naftali; Adegunsoye, Ayodeji; Strek, Mary E.; Neighbors, Margaret; Sheng, Xuting R.; Guðmundsson, Gunnar; Gudnason, Vilmundur; Hatabu, Hiroto; Lederer, David J.; Manichaikul, Ani; Newell, John D.; O’Connor, George T.; Ortega, Victor E.; Xu, Hanfei; Fingerlin, Tasha E.; Bossé, Yohan; Hao, Ke; Joubert, Philippe; Nickle, David C.; Sin, Don D.; Timens, Wim; Furniss, Dominic; Morris, Andrew P.; Zondervan, Krina T.; Hall, Ian P.; Sayers, Ian; Tobin, Martin D.; Maher, Toby M.; Cho, Michael H.; Hunninghake, Gary M.; Schwartz, David A.; Yaspan, Brian L.; Molyneaux, Philip L.; Flores, Carlos; Noth, Imre; Jenkins, R. Gisli; Wain, Louise V. (American Thoracic Society, 2020-03-01)
    Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of ...
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    A genome-wide association study yields five novel thyroid cancer risk loci 
    Guðmundsson, Júlíus; Þorleifsson, Guðmar; Sigurðsson, Jón K.; Stefánsdóttir, Lilja; Jónasson, Jón G.; Guðjónsson, Sigurjón Axel; Gudbjartsson, Daniel; Másson, Gísli; Jóhannsdóttir, Hrefna; Halldórsson, Gísli H.; Stacey, Simon N.; Helgason, Hannes; sulem, patrick; Senter, Leigha; He, Huiling; Liyanarachchi, Sandya; Ringel, Matthew D.; Aguillo, Esperanza; Panadero, Angeles; Prats, Enrique; Garcia-Castaño, Almudena; De Juan, Ana; Rivera, Fernando; Xu, Li; Kiemeney, Lambertus A.; Eyjólfsson, Guðmundur I.; Sigurðardóttir, Ólöf; Ólafsson, Ísleifur; Kristvinsson, Höskuldur; Netea-Maier, Romana T.; Jónsson, Þorvaldur; Mayordomo, Jose I.; Plantinga, Theo S.; Hjartarson, Hannes; Hrafnkelsson, Jón; Sturgis, Erich M.; Þorsteinsdóttir, Unnur; Rafnar, Thorunn; de la Chapelle, Albert; Stefansson, Kari (Springer Nature, 2017-02-14)
    The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European ...
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    Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA 
    Gudmundsson, Julius; Sigurðsson, Jón K.; Stefánsdóttir, Lilja; Agnarsson, Bjarni A.; Ísaksson, Helgi J.; Stefánsson, Ólafur A.; Guðjónsson, Sigurjón Axel; Gudbjartsson, Daniel; Másson, Gísli; Frigge, Michael L.; Stacey, Simon N.; sulem, patrick; Halldorsson, Gisli; Tragante, Vinicius; Holm, Hilma; Eyjólfsson, Guðmundur I.; Sigurðardóttir, Ólöf; Olafsson, Isleifur; Jónsson, Þorvaldur; Jónsson, Eirikur; Barkardottir, Rosa Bjork; Hilmarsson, Rafn; Asselbergs, Folkert W.; Geirsson, Guðmundur; Thorsteinsdottir, Unnur; Rafnar, Thorunn; Thorleifsson, Gudmar; Stefansson, Kari (Springer Science and Business Media LLC, 2018-11-08)
    Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients ...
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    A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine 
    Guo, Yanjun; Stefansson, Kari (Springer Science and Business Media LLC, 2020-07-06)
    Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP ...
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    Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning 
    Lahti, Jari; Tuominen, Samuli; Yang, Qiong; Pergola, Giulio; Ahmad, Shahzad; Amin, Najaf; Armstrong, Nicola J.; Beiser, Alexa; Bey, Katharina; Bis, Joshua C.; Boerwinkle, Eric; Bressler, Jan; Campbell, Archie; Campbell, Harry; Chen, Qiang; Corley, Janie; Cox, Simon R.; Davies, Gail; De Jager, Philip L.; Derks, Eske M.; Faul, Jessica D.; Fitzpatrick, Annette L.; Fohner, Alison E.; Ford, Ian; Fornage, Myriam; Gerring, Zachary; Grabe, Hans J.; Grodstein, Francine; Gudnason, Vilmundur; Simonsick, Eleanor; Holliday, Elizabeth G.; Joshi, Peter K.; Kajantie, Eero; Kaprio, Jaakko; Karell, Pauliina; Kleineidam, Luca; Knol, Maria J.; Kochan, Nicole A.; Kwok, John B.; Leber, Markus; Lam, Max; Lee, Teresa; Li, Shuo; Loukola, Anu; Luck, Tobias; Marioni, Riccardo E.; Mather, Karen A.; Medland, Sarah; Mirza, Saira S.; Nalls, Mike A. (2022-08-16)
    Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke ...
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    A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome 
    DBDS Genetic Consortium (2022-03-24)
    Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and has a largely unknown underlying biology. In a genome-wide association study of CTS (48,843 cases and 1,190,837 controls), we found 53 sequence variants at 50 loci associated ...
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    Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma 
    Sarin, Kavita Y.; Lin, Yuan; Daneshjou, Roxana; Ziyatdinov, Andrey; Thorleifsson, Gudmar; Rubin, Adam; Pardo, Luba M.; Wu, Wenting; Khavari, Paul A.; Uitterlinden, Andre; Nijsten, Tamar; Toland, Amanda E.; Ólafsson, Jón H.; Sigurgeirsson, Bárður; Þórisdóttir, Kristín; Jorgensen, Eric; Whittemore, Alice S.; Kraft, Peter; Stacey, Simon; Stefansson, Kari; Asgari, Maryam M.; Han, Jiali (Springer Science and Business Media LLC, 2020-02-10)
    Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in the United States. Previous genome-wide association studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associated with cutaneous SCC. Here, we report the ...
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    Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits 
    Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S.; Ahluwalia, Tarunveer S.; Chu, Audrey Y.; Heard-Costa, Nancy L.; Lim, Elise; Perez, Jeremiah; Eicher, John D.; Kutalik, Zoltán; Xue, Luting; Mahajan, Anubha; Renström, Frida; Wu, Joseph; Qi, Qibin; Ahmad, Shafqat; Alfred, Tamuno; Amin, Najaf; Bielak, Lawrence F.; Bonnefond, Amélie; Bragg, Jennifer; Cadby, Gemma; Chittani, Martina; Coggeshall, Scott; Corre, Tanguy; Direk, Nese; Eriksson, Joel; Fischer, Krista; Gorski, Mathias; Neergaard Harder, Marie; Horikoshi, Momoko; Huang, Tao; Huffman, Jennifer E.; Jackson, Anne U.; Justesen, Johanne Marie; Kanoni, Stavroula; Kinnunen, Leena; Kleber, Marcus E.; Komulainen, Pirjo; Kumari, Meena; Lim, Unhee; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Middelberg, Rita P. S.; Müller-Nurasyid, Martina; Navarro, Pau; Pérusse, Louis; Pervjakova, Natalia; Sarti, Cinzia; Smith, Albert Vernon; Smith, Jennifer A.; Stančáková, Alena; Strawbridge, Rona J.; Stringham, Heather M.; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W.; van der Most, Peter J.; Van Vliet-Ostaptchouk, Jana V.; Vedantam, Sailaja L.; Verweij, Niek; Vink, Jacqueline M.; Vitart, Veronique; Wu, Ying; Yengo, Loic; Zhang, Weihua; Hua Zhao, Jing; Zimmermann, Martina E.; Zubair, Niha; Abecasis, Gonçalo R.; Adair, Linda S.; Afaq, Saima; Afzal, Uzma; Bakker, Stephan J. L.; Bartz, Traci M.; Beilby, John; Bergman, Richard N.; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L.; Bottinger, Erwin; Braga, Daniele; Buckley, Brendan M.; Buyske, Steve; Campbell, Harry; Chambers, John C.; Collins, Francis; Curran, Joanne E.; de Borst, Gert J.; de Craen, Anton J. M.; de Geus, Eco J. C.; Dedoussis, George; Delgado, Graciela E.; den Ruijter, Hester M.; Eiríksdóttir, Guðný; Eriksson, Anna L.; Esko, Tõnu; Faul, Jessica D.; Ford, Ian; Forrester, Terrence; Gertow, Karl; Gigante, Bruna; Glorioso, Nicola; Gong, Jian; Grallert, Harald; Grammer, Tanja B.; Grarup, Niels; Haitjema, Saskia; Hallmans, Göran; Hamsten, Anders; Hansen, Torben; Harris, Tamara B.; Hartman, Catharina A.; Hassinen, Maija; Hastie, Nicholas D.; Heath, Andrew C.; Hernandez, Dena; Hindorff, Lucia; Hocking, Lynne J.; Hollensted, Mette; Holmen, Oddgeir L.; Homuth, Georg; Jan Hottenga, Jouke; Huang, Jie; Hung, Joseph; Hutri-Kähönen, Nina; Ingelsson, Erik; James, Alan L.; Jansson, John-Olov; Jarvelin, Marjo-Riitta; Jhun, Min A.; Jørgensen, Marit E.; Juonala, Markus; Kähönen, Mika; Karlsson, Magnus; Koistinen, Heikki A.; Kolcic, Ivana; Kolovou, Genovefa; Kooperberg, Charles; Krämer, Bernhard K.; Kuusisto, Johanna; Kvaløy, Kirsti; Lakka, Timo; Langenberg, Claudia; Launer, Lenore J.; Leander, Karin; Lee, Nanette R.; Lind, Lars; Lindgren, Cecilia; Linneberg, Allan; Lobbens, Stephane; Loh, Marie; Lorentzon, Mattias; Luben, Robert; Lubke, Gitta; Ludolph-Donislawski, Anja; Lupoli, Sara; Madden, Pamela A. F.; Männikkö, Reija; Marques-Vidal, Pedro; Martin, Nicholas G.; McKenzie, Colin A.; McKnight, Barbara; Mellström, Dan; Menni, Cristina; Montgomery, Grant W.; Musk, A.W.; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M.; Oldehinkel, Albertine J.; Olden, Matthias; Ong, Ken K.; Padmanabhan, Sandosh; Peyser, Patricia A.; Pisinger, Charlotta; Porteous, David J.; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rasmussen-Torvik, Laura J.; Rawal, Rajesh; Rice, Treva; Ridker, Paul M.; Rose, Lynda M.; Bien, Stephanie A.; Rudan, Igor; Sanna, Serena; Sarzynski, Mark A.; Sattar, Naveed; Savonen, Kai; Schlessinger, David; Scholtens, Salome; Schurmann, Claudia; Scott, Robert A.; Sennblad, Bengt; Siemelink, Marten A.; Silbernagel, Günther; Slagboom, P Eline; Snieder, Harold; Staessen, Jan A.; Stott, David J.; Swertz, Morris A.; Swift, Amy J.; Taylor, Kent D.; Tayo, Bamidele O.; Thorand, Barbara; Thuillier, Dorothée; Tuomilehto, Jaakko; Uitterlinden, André G.; Vandenput, Liesbeth; Vohl, Marie-Claude; Völzke, Henry; Vonk, Judith M.; Waeber, Gérard; Waldenberger, Melanie; Westendorp, R. G. J.; Wild, Sarah; Willemsen, Gonneke; Wolffenbuttel, Bruce H. R.; Wong, Andrew; Wright, Alan F.; Zhao, Wei; Zillikens, M Carola; Baldassarre, Damiano; Balkau, Beverley; Bandinelli, Stefania; Böger, Carsten A.; Boomsma, Dorret I.; Bouchard, Claude; Bruinenberg, Marcel; Chasman, Daniel I.; Chen, Yii-DerIda; Chines, Peter S.; Cooper, Richard S.; Cucca, Francesco; Cusi, Daniele; Faire, Ulf de; Ferrucci, Luigi; Franks, Paul W.; Froguel, Philippe; Gordon-Larsen, Penny; Grabe, Hans Jörgen; Gudnason, Vilmundur; Haiman, Christopher A.; Hayward, Caroline; Hveem, Kristian; Johnson, Andrew D.; Wouter Jukema, J; Kardia, Sharon L. R.; Kivimaki, Mika; Kooner, Jaspal S.; Kuh, Diana; Laakso, Markku; Lehtimäki, Terho; Marchand, Loic Le; März, Winfried; McCarthy, Mark I.; Metspalu, Andres; Morris, Andrew P.; Ohlsson, Claes; Palmer, Lyle J.; Pasterkamp, Gerard; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Psaty, Bruce M.; Qi, Lu; Rauramaa, Rainer; Smith, Blair H.; Sørensen, Thorkild I. A.; Strauch, Konstantin; Tiemeier, Henning; Tremoli, Elena; van der Harst, Pim; Vestergaard, Henrik; Vollenweider, Peter; Wareham, Nicholas J.; Weir, David R.; Whitfield, John B.; Wilson, James F.; Tyrrell, Jessica; Frayling, Timothy M.; Barroso, Inês; Boehnke, Michael; Deloukas, Panagiotis; Fox, Caroline S.; Hirschhorn, Joel N.; Hunter, David J.; Spector, Tim D.; Strachan, David P.; van Duijn, Cornelia M.; Heid, Iris M.; Mohlke, Karen L.; Marchini, Jonathan; Loos, Ruth J. F.; Kilpeläinen, Tuomas O.; Liu, Ching-Ti; Borecki, Ingrid; North, Kari E.; Cupples, L Adrienne (Springer Nature, 2017-04-26)
    Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 ...