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    Genetic and geographic influence on phenotypic variation in European sarcoidosis patients 
    Freitag-Wolf, Sandra; Schupp, Jonas C.; Frye, Björn C.; Fischer, Annegret; Anwar, Raihanatul; Kieszko, Robert; Mihailović-Vučinić, Violeta; Milanowski, Janusz; Jovanovic, Dragana; Zissel, Gernot; Bargagli, Elena; Rottoli, Paola; Bumbacea, Dragos; Jonkers, René; Ho, Ling Pei; Gaede, Karoline I.; Dubaniewicz, Anna; Marshall, Ben G.; Günther, Andreas; Petrek, Martin; Keane, Michael P.; Haraldsdóttir, Sigríður Ólína; Bonella, Francesco; Grah, Christian; Peroš-Golubičić, Tatjana; Kadija, Zamir; Pabst, Stefan; Grohé, Christian; Strausz, János; Safrankova, Martina; Millar, Ann; Homolka, Jiří; Wuyts, Wim A.; Spencer, Lisa G.; Pfeifer, Michael; Valeyre, Dominique; Poletti, Venerino; Wirtz, Hubertus; Prasse, Antje; Schreiber, Stefan; Dempfle, Astrid; Müller-Quernheim, Joachim (2023-08-09)
    Introduction: Sarcoidosis is a highly variable disease in terms of organ involvement, type of onset and course. Associations of genetic polymorphisms with sarcoidosis phenotypes have been observed and suggest genetic signatures. Methods: After obtaining ...
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    Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting 
    Chauhan, Ganesh; Adams, Hieab H.H.; Satizabal, Claudia L.; Bis, Joshua C.; Teumer, Alexander; Sargurupremraj, Muralidharan; Hofer, Edith; Trompet, Stella; Hilal, Saima; Smith, Albert Vernon; Jian, Xueqiu; Malik, Rainer; Traylor, Matthew; Pulit, Sara L.; Amouyel, Philippe; Mazoyer, Bernard; Zhu, Yi-Cheng; Kaffashian, Sara; Schilling, Sabrina; Beecham, Gary W.; Montine, Thomas J.; Schellenberg, Gerard D.; Kjartansson, Olafur; Gudnason, Vilmundur; Knopman, David S.; Griswold, Michael E.; Windham, B. Gwen; Gottesman, Rebecca F.; Mosley, Thomas H.; Schmidt, Reinhold; Saba, Yasaman; Schmidt, Helena; Takeuchi, Fumihiko; Yamaguchi, Shuhei; Nabika, Toru; Kato, Norihiro; Rajan, Kumar B.; Aggarwal, Neelum T.; De Jager, Philip L.; Evans, Denis A.; Psaty, Bruce M.; Rotter, Jerome I.; Rice, Kenneth; Lopez, Oscar L.; Liao, Jiemin; Chen, Christopher; Cheng, Ching-Yu; Wong, Tien Y.; Ikram, Mohammad K.; van der Lee, Sven J.; Amin, Najaf; Chouraki, Vincent; DeStefano, Anita L.; Aparicio, Hugo J.; Romero, Jose R.; Maillard, Pauline; DeCarli, Charles; Wardlaw, Joanna M.; Hernández, Maria del C. Valdés; Luciano, Michelle; Liewald, David; Deary, Ian J.; Starr, John M.; Bastin, Mark E.; Muñoz Maniega, Susana; Slagboom, P. Eline; Beekman, Marian; Deelen, Joris; Uh, Hae-Won; Lemmens, Robin; Brodaty, Henry; Wright, Margaret J.; Ames, David; Boncoraglio, Giorgio B.; Hopewell, Jemma C.; Beecham, Ashley H.; Blanton, Susan H.; Wright, Clinton B.; Sacco, Ralph L.; Wen, Wei; Thalamuthu, Anbupalam; Armstrong, Nicola J.; Chong, Elizabeth; Schofield, Peter R.; Kwok, John B.; van der Grond, Jeroen; Stott, David J.; Ford, Ian; Jukema, J. Wouter; Vernooij, Meike W.; Hofman, Albert; Uitterlinden, André G.; van der Lugt, Aad; Wittfeld, Katharina; Grabe, Hans J.; Hosten, Norbert; von Sarnowski, Bettina; Völker, Uwe; Levi, Christopher; Jimenez-Conde, Jordi; Sharma, Pankaj; Sudlow, Cathie L.M.; Rosand, Jonathan; Woo, Daniel; Cole, John W.; Meschia, James F.; Slowik, Agnieszka; Thijs, Vincent; Lindgren, Arne; Melander, Olle; Grewal, Raji P.; Rundek, Tatjana; Rexrode, Kathy; Rothwell, Peter M.; Arnett, Donna K.; Jern, Christina; Johnson, Julie A.; Benavente, Oscar R.; Wasssertheil-Smoller, Sylvia; Lee, Jin-Moo; Wong, Quenna; Mitchell, Braxton D.; Rich, Stephen S.; McArdle, Patrick F.; Geerlings, Mirjam I.; van der Graaf, Yolanda; de Bakker, Paul I.W.; Asselbergs, Folkert W.; Srikanth, Velandai; Thomson, Russell; McWhirter, Rebekah; Moran, Chris; Callisaya, Michele; Phan, Thanh; Rutten-Jacobs, Loes C.A.; Bevan, Steve; Tzourio, Christophe; Mather, Karen A.; Sachdev, Perminder S.; van Duijn, Cornelia M.; Worrall, Bradford B.; Dichgans, Martin; Kittner, Steven J.; Markus, Hugh S.; Ikram, Mohammad A.; Fornage, Myriam; Launer, Lenore J.; Seshadri, Sudha; Longstreth, W.T.; Debette, Stéphanie (Ovid Technologies (Wolters Kluwer Health), 2019-01-29)
    Objective: To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. Methods We performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors ...
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    Genetic architecture of band neutrophil fraction in Iceland 
    Oskarsson, Gudjon R.; Magnússon, Magnús Karl; Oddson, Ásmundur; Jensson, Brynjar O; Friðriksdóttir, Rún; Arnadottir, Gudny A; Katrinardottir, Hildigunnur; Rögnvaldsson, Sölvi; Halldórsson, Gísli Hreinn; Sveinbjörnsson, Gardar; Ivarsdottir, Erna V.; Stefánsdóttir, Lilja; Ferkingstad, Egil; Norland, Kristjan; Tragante, Vinicius; Sæmundsdóttir, Jóna; Jónasdóttir, Áslaug; Jonasdottir, Adalbjorg; Sigurjonsdottir, Svanhvit; Petursdottir, Karen O.; Davidsson, Olafur B; Rafnar, Thorunn; Hólm, Hilma; Ólafsson, Ísleifur; Önundarson, Páll Torfi; Viðarsson, Brynjar; Sigurdardottir, Olof G.; Másson, Gísli; Gudbjartsson, Daniel Fannar; Jónsdóttir, Ingileif; Norddahl, Gudmundur L.; Þorsteinsdóttir, Unnur; Sulem, Patrick; Stefánsson, Kári (2022-06-01)
    The characteristic lobulated nuclear morphology of granulocytes is partially determined by composition of nuclear envelope proteins. Abnormal nuclear morphology is primarily observed as an increased number of hypolobulated immature neutrophils, called ...
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    Genetic architecture of childhood neuropsychiatric and involuntary movement disorders 
    Nawaz, Muhammad Sulaman (University of Iceland, School of Health Sciences, Faculty of Medicine, 2022-12)
    Neurodevelopmental disorders on the impulsivity-compulsivity spectrum are chronic disabling conditions with an early onset. High rates of comorbidity have been reported between Tourette syndrome (TS), Tics disorder (Tics), obsessive compulsive ...
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    Genetic association of gemcitabine/carboplatin-induced leukopenia and neutropenia in non-small cell lung cancer patients using whole-exome sequencing 
    Svedberg, Anna; Björn, Niclas; Sigurgeirsson, Benjamín; Pradhananga, Sailendra; Brandén, Eva; Koyi, Hirsh; Lewensohn, Rolf; De Petris, Luigi; Apellániz-Ruiz, María; Rodríguez-Antona, Cristina; Lundeberg, Joakim; Gréen, Henrik (Elsevier BV, 2020-09)
    Objectives: Gemcitabine/carboplatin treatment is known to cause severe adverse drug reactions which can lead to the need for reduction or cessation of chemotherapy. It would be beneficial to identify patients at risk of severe hematological toxicity ...
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    Genetic effects on the timing of parturition and links to fetal birth weight 
    Early Growth Genetics Consortium; Steingrímsdóttir, Þóra (2023-04-03)
    The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 ...
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    Genetic epidemiology of cancer in Romania 
    Iordache, Paul (2019-02)
    In Romania, there is a lack of quantitative data associating cancer risk with genetic characteristics. The aim of this thesis is to evaluate genetic risk factors associated with two major cancer types, prostate cancer and colorectal cancer. The first ...
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    Genetic insight into sick sinus syndrome 
    DBDS Genomic Consortium (2021-02-13)
    Aims: The aim of this study was to use human genetics to investigate the pathogenesis of sick sinus syndrome (SSS) and the role of risk factors in its development. Methods and results: We performed a genome-wide association study of 6469 SSS cases and ...
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    Genetic insights into resting heart rate and its role in cardiovascular disease 
    DCCT/EDIC Research Group; Arnar, Davíð Ottó (2023-08-02)
    Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further ...
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    Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium 
    Weng, Lu-Chen; Lunetta, Kathryn L.; Müller-Nurasyid, Martina; Smith, Albert Vernon; Thériault, Sébastien; Weeke, Peter E.; Barnard, John; Bis, Joshua C.; Lyytikäinen, Leo-Pekka; Kleber, Marcus E.; Martinsson, Andreas; Lin, Henry J.; Rienstra, Michiel; Trompet, Stella; Krijthe, Bouwe P.; Dörr, Marcus; Klarin, Derek; Chasman, Daniel I.; Sinner, Moritz F.; Waldenberger, Melanie; Launer, Lenore J.; Harris, Tamara B.; Soliman, Elsayed Z.; Alonso, Alvaro; Paré, Guillaume; Teixeira, Pedro L.; Denny, Joshua C.; Shoemaker, M. Benjamin; Van Wagoner, David R.; Smith, Jonathan D.; Psaty, Bruce M.; Sotoodehnia, Nona; Taylor, Kent D.; Kähönen, Mika; Nikus, Kjell; Delgado, Graciela E.; Melander, Olle; Engström, Gunnar; Yao, Jie; Guo, Xiuqing; Christophersen, Ingrid E.; Ellinor, Patrick T.; Geelhoed, Bastiaan; Verweij, Niek; Macfarlane, Peter; Ford, Ian; Heeringa, Jan; Franco, Oscar H.; Uitterlinden, André G.; Völker, Uwe; Teumer, Alexander; Rose, Lynda M.; Kääb, Stefan; Gudnason, Vilmundur; Arking, Dan E.; Conen, David; Roden, Dan M.; Chung, Mina K.; Heckbert, Susan R.; Benjamin, Emelia J.; Lehtimäki, Terho; März, Winfried; Smith, J. Gustav; Rotter, Jerome I.; van der Harst, Pim; Jukema, J. Wouter; Stricker, Bruno H.; Felix, Stephan B.; Albert, Christine M.; Lubitz, Steven A. (Springer Nature, 2017-09-12)
    It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. ...
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    Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies 
    Lifelines Cohort Study (2022-09)
    Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain ...
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    Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium 
    Hahn, Julie; Fu, Yi Ping; Brown, Michael R.; Bis, Joshua C.; de Vries, Paul S.; Feitosa, Mary F.; Yanek, Lisa R.; Weiss, Stefan; Giulianini, Franco; Smith, Albert Vernon; Guo, Xiuqing; Bartz, Traci M.; Becker, Diane M.; Becker, Lewis C.; Boerwinkle, Eric; Brody, Jennifer A.; Chen, Yii Der Ida; Franco, Oscar H.; Grove, Megan; Harris, Tamara B.; Hofman, Albert; Hwang, Shih Jen; Kral, Brian G.; Launer, Lenore J.; Markus, Marcello R.P.; Rice, Kenneth M.; Rich, Stephen S.; Ridker, Paul M.; Rivadeneira, Fernando; Rotter, Jerome I.; Sotoodehnia, Nona; Taylor, Kent D.; Uitterlinden, André G.; Völker, Uwe; Völzke, Henry; Yao, Jie; Chasman, Daniel I.; Dörr, Marcus; Gudnason, Vilmundur; Mathias, Rasika A.; Post, Wendy; Psaty, Bruce M.; Dehghan, Abbas; O’Donnell, Christopher J.; Morrison, Alanna C. (2020-11)
    Background Genome-wide association studies have identified multiple genomic loci associated with coronary artery disease, but most are common variants in non-coding regions that provide limited information on causal genes and etiology of the disease. ...
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    Genetic parameters for Icelandic dairy cows using a random regression test-day model 
    Eiríksson, Jón Hjalti; Sigurdsson, Agust; Jóhannesson, Guðmundur; Eythorsdottir, Emma (Agricultural University of Iceland, 2019)
    A total of 480,495 test-day yield records of 33,052 cows were used to estimate the genetic parameters for daily milk yield (MY), fat yield (FY), protein yield (PY) and somatic cell score (SCS) of Icelandic dairy cows in the first three lactations with ...
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    A Genetic Polymorphism in CTLA-4 Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma 
    Liu, Xiaoyan; Swen, Jesse J.; Diekstra, Meta H.M.; Boven, Epie; Castellano, Daniel; Gelderblom, Hans; Mathijssen, Ron H.J.; Vermeulen, Sita H.; Oosterwijk, Egbert; Junker, Kerstin; Roessler, Max; Alexiusdottir, Kristin; Sverrisdóttir, Ásgerður; Radu, Marius T.; Ambert, Valentin; Eisen, Tim; Warren, Anne; Rodríguez-Antona, Cristina; García-Donas, Jesus; Böhringer, Stefan; Koudijs, Karel K.M.; Kiemeney, Lambertus A.L.M.; Rini, Brian I.; Guchelaar, Henk-Jan (2018-05-15)
    Purpose: The survival of patients with clear cell metastatic renal cell carcinoma (cc-mRCC) has improved substantially since the introduction of tyrosine kinase inhibitors (TKI). With the fact that TKIs interact with immune responses, we investigated ...
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    Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus 
    Van Zuydam, Natalie R.; Ladenvall, Claes; Voight, Benjamin F.; Strawbridge, Rona J.; Fernandez-Tajes, Juan; Rayner, N. William; Robertson, Neil R.; Mahajan, Anubha; Vlachopoulou, Efthymia; Goel, Anuj; Kleber, Marcus E.; Nelson, Christopher P.; Kwee, Lydia Coulter; Esko, Tõnu; Mihailov, Evelin; Mägi, Reedik; Milani, Lili; Fischer, Krista; Kanoni, Stavroula; Kumar, Jitender; Song, Ci; Hartiala, Jaana A.; Pedersen, Nancy L.; Perola, Markus; Gieger, Christian; Peters, Annette; Qu, Liming; Willems, Sara M.; Doney, Alex S.F.; Morris, Andrew D.; Zheng, Yan; Sesti, Giorgio; Hu, Frank B.; Qi, Lu; Laakso, Markku; Thorsteinsdottir, Unnur; Grallert, Harald; Van Duijn, Cornelia; Reilly, Muredach P.; Ingelsson, Erik; Deloukas, Panos; Kathiresan, Sek; Metspalu, Andres; Shah, Svati H.; Sinisalo, Juha; Salomaa, Veikko; Hamsten, Anders; Samani, Nilesh J.; März, Winfried; Hazen, Stanley L. (2020-12-01)
    Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of ...
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    Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women 
    FINNPEC Consortium; GOPEC Consortium; Thorsteinsdottir, Unnur (2020-12)
    Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal ...
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    Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens 
    Nicoletti, Paola; Devarbhavi, Harshad; Goel, Ashish; Venkatesan, Radha; Eapen, Chundamannil E.; Grove, Jane I.; Zafer, Samreen; Björnsson, Einar Stefán; Lucena, M. Isabel; Andrade, Raul J.; Pirmohamed, Munir; Wadelius, Mia; Larrey, Dominique; Maitland-van der Zee, Anke Hilse; Ibanez, Luisa; Watkins, Paul B.; Daly, Ann K.; Aithal, Guruprasad P. (2021-04)
    Drug-induced liver injury (DILI) is a complication of treatment with antituberculosis (TB) drugs, especially in isoniazid (INH)-containing regimens. To investigate genetic risk factors, we performed a genomewide association study (GWAS) involving anti-TB ...
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    The genetic structure of Norway 
    Mattingsdal, Morten; Ebenesersdóttir, Sigríður Sunna; Moore, Kristjan Helgi Swerford; Andreassen, Ole A.; Hansen, Thomas Folkmann; Werge, Thomas M.; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Helgason, Agnar Sturla; Stefánsson, Kári; Hovig, Eivind (2021-11)
    The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based ...
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    Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial 
    Norén-Nyström, Ulrika; Andersen, Mette K; Barbany, Gisela; Dirse, Vaidas; Eilert-Olsen, Martine; Engvall, Marie; Harila-Saari, Arja; Heyman, Mats; Hovland, Randi; Häikiö, Satu; Jónsson, Jón Jóhannes; Karhu, Ritva; Kjeldsen, Eigil; Norberg, Anna; Preiss, Birgitte S; Pulkkinen, Kati; Quist-Paulsen, Petter; Räsänen, Hannele; Schmiegelow, Kjeld; Seitsonen, Anne; Sjögren, Helene; Tammur, Pille; Johansson, Bertil (2023-05-04)
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    Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease 
    Helgadottir, Anna; Thorleifsson, Gudmar; Alexandersson, Kristjan F; Tragante, Vinicius; Þorsteinsdóttir, Margrét; Eiriksson, Finnur Freyr; Grétarsdóttir, Sólveig; Björnsson, Eyþór; Magnússon, Ólafur; Sveinbjornsson, Gardar; Jonsdottir, Ingileif; Steinthorsdottir, Valgerdur; Ferkingstad, Egil; Jensson, Brynjar Ö; Stefansson, Hreinn; Olafsson, Isleifur; Christensen, Alex H; Torp-Pedersen, Christian; Køber, Lars; Pedersen, Ole B; Erikstrup, Christian; Sørensen, Erik; Brunak, Søren; Banasik, Karina; Hansen, Thomas F; Nyegaard, Mette; Eyjólfsson, Guðmundur I.; Sigurdardottir, Olof; Þórarinsson, Björn L; Matthíasson, Stefán E.; Steingrimsdottir, Thora; Björnsson, Einar Stefán; Danielsen, Ragnar; Asselbergs, Folkert W.; Arnar, David O; Ullum, Henrik; Bundgaard, Henning; sulem, patrick; Thorsteinsdottir, Unnur; Thorgeirsson, Gudmundur; Holm, Hilma; Gudbjartsson, Daniel; Stefansson, Kari (Oxford University Press (OUP), 2020-07-21)
    Aims: To explore whether variability in dietary cholesterol and phytosterol absorption impacts the risk of coronary artery disease (CAD) using as instruments sequence variants in the ABCG5/8 genes, key regulators of intestinal absorption of dietary ...