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Fletta eftir efnisorði "Brjóstakrabbamein"
Atriði 21-40 af 44
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(Springer Science and Business Media LLC, 2019-04-15)Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and ... -
(University of Iceland, School of Health Sciences, Faculty of Medicine, 2016-12)Background and aims: Previous studies in geothermal and volcanic areas have shown high risk of certain types of cancers. The aim was to study the association between residence in geothermal areas and the incidence and mortality of cancer in ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-08)The microenvironment is increasingly being recognized as a key player in supporting cancer progression. Therefore, investigating heterotypic interactions between cancer cells and their microenvironment is important for improving our understanding ...
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(Public Library of Science (PLoS), 2019-08-23)Background: Fusion genes result from genomic structural changes, which can lead to alterations in gene expression that supports tumor development. The aim of the study was to use fusion genes as a tool to identify new breast cancer (BC) genes with a ...
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(2021-11-19)Breast cancer is the cancer most often diagnosed in women. MicroRNAs (MIRs) are short RNA molecules that bind mRNA resulting in their downregulation. MIR21 has been shown to be an oncomiR in most cancer types, including breast cancer. Most of the effects ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2021-06-15)Breast cancer is the most common type of cancer in women worldwide. It is also a highly heterogeneous disease that is characterized by an array of genetic rearrangements, including copy number alterations (CNA), translocations, inversions, ...
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(Springer Nature, 2017-05-11)Protein tyrosine phosphatase 1B (PTP1B) is a well-known inhibitor of insulin signaling pathways and inhibitors against PTP1B are being developed as promising drug candidates for treatment of obesity. PTP1B has also been linked to breast cancer both as ...
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(Public Library of Science (PLoS), 2020-04-14)Breast cancer (BC) is the most prevalent type of cancer in women in western countries. BC mortality has not declined despite early detection by screening, indicating the need for better informed treatment decisions. Therefore, a novel noninvasive ...
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(Wiley, 2020-07-27)Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide-conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells, where it is ...
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(Elsevier BV, 2017-06)Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes place during EMT are still limited. ...
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Metabolic systems analysis of breast epithelial cells following epithelial-to-mesenchymal transition (University of Iceland, School of Health Sciences, Faculty of Medicine, 2022-02-25)Breast cancer is a heterogenous disease in which the mechanism for signalling, gene expression, metabolism and growth in breast tissue is deranged. Breast cancer is responsible for the death of over 600,000 people worldwide on a yearly basis. By ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2023-03-30)Breast cancer is the most frequently diagnosed cancer today, with approximately 2.3 million new cases for the year 2020. Regardless of gender, these diagnoses represent 11.7% of all cases. For women, breast cancer falls under roughly one-third of cancer ...
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(Springer Science and Business Media LLC, 2020-09-26)Purpose of Review: Long-term survival has increased significantly in breast cancer patients, and cardiovascular side effects are surpassing cancer-related mortality. We summarize risk factors, prevention strategies, detection, and management of ...
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(Springer Science and Business Media LLC, 2020-04-22)Metastatic progression is the leading cause of mortality in breast cancer. Invasive tumor cells develop invadopodia to travel through basement membranes and the interstitial matrix. Substantial efforts have been made to characterize invadopodia molecular ...
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(Springer Science and Business Media LLC, 2019-12-10)Background: An increasing number of women are evaluated for potential breast cancer and may experience mental distress during evaluation. We aim to assess the risks of psychiatric disorders and cardiovascular diseases during the diagnostic workup of ...
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(Wiley, 2020-07-14)Little is known about how health insurance policies, particularly in developing countries, influence breast cancer prognosis. Here, we examined the association between individual health insurance and breast cancer-specific mortality in China. We included ...
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(Oxford University Press (OUP), 2017-09-01)Background: Telephone delivery of genetic counseling is an alternative to in-person genetic counseling because it may extend the reach of genetic counseling. Previous reports have established the noninferiority of telephone counseling on short-term ...
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(University of Iceland, School of Health Sciences, Faculty of Food Science and Nutrition, 2020-02)Background and aims : Previous studies have provided evidence for the importance of early life environment on breast cancer development. The aim of this study was to advance knowledge on the association of growth rate in early life and lifelong ...
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(Springer Science and Business Media LLC, 2020-09-15)An association between schizophrenia and subsequent breast cancer has been suggested; however the risk of schizophrenia following a breast cancer is unknown. Moreover, the driving forces of the link are largely unclear. Here, we report the phenotypic ...
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(Springer Science and Business Media LLC, 2019-01-25)Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 ...
Atriði 21-40 af 44