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Fletta eftir efnisorði "Ónæmisfræði"

Fletta eftir efnisorði "Ónæmisfræði"

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    Host Directed Therapy Against Infection by Boosting Innate Immunity 
    Bergman, Peter; Raqib, Rubhana; Rekha, Rokeya Sultana; Agerberth, Birgitta; Gudmundsson, Gudmundur H (Frontiers Media SA, 2020-06-12)
    The innate immune system constitutes the first line of defense against invading pathogens, regulating the normal microbiota and contributes to homeostasis. Today we have obtained detailed knowledge on receptors, signaling pathways, and effector molecules ...
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    Mapping of Signaling Pathways Linked to sIgAD Reveals Impaired IL-21 Driven STAT3 B-Cell Activation 
    Lemarquis, Andri Leo; Theodors, Fannar; Einarsdottir, Helga K.; Ludviksson, Bjorn (Frontiers Media SA, 2019-03-18)
    Objectives: It has recently been shown that individuals with selective IgA deficiency (sIgAD) have defective B cell responses both to T cell dependent and independent mimicking stimulations. The complex intracellular signaling pathways from different ...
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    Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study) : A protocol for an observational longitudinal case-control study 
    Asbjornsdottir, Birna; Lauth, Bertrand; Fasano, Alessio; Thorsdottir, Inga; Karlsdottir, Ingibjorg; Gudmundsson, Larus S.; Gottfredsson, Magnus; Smarason, Orri; Sigurðardóttir, Sigurveig Þ; Halldorsson, Thorhallur I.; Marteinsson, Viggo Thor; Gudmundsdottir, Valborg; Birgisdottir, Bryndis Eva (2022-09-01)
    Recent studies indicate that the interplay between diet, intestinal microbiota composition, and intestinal permeability can impact mental health. More than 10% of children and adolescents in Iceland suffer from mental disorders, and rates of psychotropics ...
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    Modulation of immune responses using adjuvants to facilitate therapeutic vaccination 
    Schijns, Virgil; Fernández‐Tejada, Alberto; Barjaktarović, Žarko; Bouzalas, Ilias; Brimnes, Jens; Chernysh, Sergey; Gizurarson, Sveinbjorn; Gursel, Ihsan; Jakopin, Žiga; Lawrenz, Maria; Nativi, Cristina; Paul, Stephane; Pedersen, Gabriel Kristian; Rosano, Camillo; Ruiz‐de‐Angulo, Ane; Slütter, Bram; Thakur, Aneesh; Christensen, Dennis; Lavelle, Ed C. (Wiley, 2020-06-28)
    Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non-infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination can at least in principle be ...
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    Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset 
    Sævarsdóttir, Sædís; Stefansdottir, Lilja; Sulem, P.; Thorleifsson, G.; Ferkingstad, E.; Rutsdottir, G.; Glintborg, B.; Westerlind, H.; Gröndal, Gerður María; Loft, I.C.; Sorensen, S.B.; Lie, B.A.; Brink, M.; Arlestig, L.; Arnthorsson, A.O.; Baecklund, E.; Banasik, K.; Bank, S.; Bjorkman, L.I.; Ellingsen, T.; Erikstrup, C.; Frei, O.; Gjertsson, I.; Gudbjartsson, D.F.; Gudjonsson, S.A.; Halldorsson, G.H.; Hendricks, O.; Hillert, J.; Hogdall, E.; Jacobsen, Sø; Jensen, D.V.; Jonsson, Helgi; Kastbom, A.; Kockum, I.; Kristensen, S.; Kristjansdottir, Helga; Larsen, M.H.; Linauskas, A.; Hauge, E.-M.; Loft, A.G.; Lúðvíksson, Björn Rúnar; Lund, S.H.; Markusson, Þorsteinn; Masson, G.; Melsted, P.; Moore, K.H.S.; Munk, H.; Nielsen, K.R.; Norddahl, G.L.; Oddsson, A.; Olafsdottir, T.A.; Olason, P.I.; Olsson, T.; Ostrowski, S.R.; Hørslev-Petersen, K.; Rognvaldsson, S.; Sanner, H.; Silberberg, G.N.; Stefansson, H.; Sørensen, E.; Sørensen, I.J.; Turesson, C.; Bergman, T.; Alfredsson, L.; Kvien, T.K.; Brunak, Sø; Steinsson, K.; Andersen, V.; Andreassen, O.A.; Rantapää-Dahlqvist, S.; Hetland, M.L.; Klareskog, L.; Askling, J.; Padyukov, L.; Pedersen, O.B.V.; Thorsteinsdottir, U.; Jonsdottir, I.; Stefánsson, Kári (2022-04-25)
    Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and ∼1 million ...
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    Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis 
    Guðmundsdóttir, Judith Amalía; Thorgeirsdottir, Sigridur; Lundbäck, Veroniqa; Göngrich, Christina; Lingman Framme, Jenny; Kindgren, Erik; Rydenman, Karin; Lúðvíksson, Björn Rúnar; Bjarnadóttir, Helga; Runarsdottir, Saga; Nilsson, Staffan; Zetterström, Rolf H.; Ekwall, Olov; Lindgren, Susanne (2023-04)
    Objective: Dysregulated central tolerance predisposes to autoimmune diseases. Reduced thymic output as well as compromised central B cell tolerance checkpoints have been proposed in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of ...
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    Pentraxins CRP-I and CRP-II are post-translationally deiminated and differ in tissue specificity in cod (Gadus morhua L.) ontogeny 
    Magnadottir, Bergljot; Hayes, Polly; Gísladóttir, Berglind; Bragason, Birkir; Hristova, Mariya; Nicholas, Anthony P.; Guðmundsdóttir, Sigríður; Lange, Sigrun (Elsevier BV, 2018-10)
    Pentraxins arefluid phase pattern recognition molecules that form an important part of the innate immunedefence and are conserved betweenfish and human. In Atlantic cod (Gadus morhuaL.), two pentraxin-likeproteins have been described, CRP-I and CRP-II. ...
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    Post-translational protein deimination in cod (Gadus morhua L.) ontogeny novel roles in tissue remodelling and mucosal immune defences? 
    Magnadottir, Bergljot; Hayes, Polly; Hristova, Mariya; Bragason, Birkir; Nicholas, Anthony P.; Dodds, Alister W.; Guðmundsdóttir, Sigríður; Lange, Sigrun (Elsevier BV, 2018-10)
    Peptidylarginine deiminases (PADs) are calcium dependent enzymes with physiological and pathophysiologicalroles conserved throughout phylogeny. PADs promote post-translational deimination of protein arginine to ci-trulline, altering the structure and ...
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    Rauðkyrningabólga í vélinda í börnum - tvö sjúkratilfelli 
    Sigurdsson, Lúther; Agnarsson, Úlfur; Axelsson, Ari Víðir (2013-12)
    Ágrip Rauðkyrningabólga í vélinda er tiltölulega nýr sjúkdómur, fyrst lýst 1978, en hefur hlotið aukna athygli síðastliðinn áratug. Í fyrstu aðallega í börnum og unglingum en síðan einnig í fullorðnum. Í yngri börnum eru vanþrif og uppköst aðaleinkenni ...
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    Searching for immunomodulatory compounds from Icelandic marine invertebrates 
    Di, Xiaxia (University of Iceland, School of Health Sciences, Faculty of Pharmaceutical Sciences, 2019-01-07)
    A substantial diversity of secondary metabolites from marine invertebrates has been described; however, only a few studies have investigated secondary metabolites of marine invertebrates collected in Icelandic waters. The unique marine environment ...
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    Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria 
    Kristjansson, Ragnar P.; Oskarsson, Gudjon R.; Skuladottir, Astros; Oddsson, Asmundur; Rognvaldsson, Solvi; Sveinbjornsson, Gardar; Lund, Sigrun H.; Jensson, Brynjar O.; Styrmisdottir, Edda L.; Halldorsson, Gisli H.; Ferkingstad, Egil; Eldjarn, Grimur Hjorleifsson; Beyter, Doruk; Kristmundsdottir, Snædis; Juliusson, Kristinn; Fridriksdottir, Run; Arnadottir, Gudny A.; Katrinardottir, Hildigunnur; Snorradottir, Margret H.; Tragante, Vinicius; Stefansdottir, Lilja; Ivarsdottir, Erna V.; Bjornsdottir, Gyda; Halldorsson, Bjarni V.; Thorleifsson, Gudmar; Lúðvíksson, Björn Rúnar; Önundarson, Páll Torfi; Sævarsdóttir, Sædís; Melsted, Pall; Norddahl, Gudmundur L.; Björnsdóttir, Unnur Steina; Olafsdottir, Thorunn; Gudbjartsson, Daniel F.; Thorsteinsdottir, Unnur; Jonsdottir, Ingileif; Sulem, Patrick; Stefansson, Kari (2023-07-10)
    Urticaria is a skin disorder characterized by outbreaks of raised pruritic wheals. In order to identify sequence variants associated with urticaria, we performed a meta-analysis of genome-wide association studies for urticaria with a total of 40,694 ...
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    Serotype and molecular epidemiology of pneumococci before and after pneumococcal vaccination 
    Quirk, Sigríður Júlía (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-04)
    The pneumococcus is a major human pathogen that causes morbidity and mortality worldwide. Pneumococci are normally carried asymptomatically in the nasopharynx of healthy pre-school children. Pneumococcal infections can range from acute otitis media ...
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    Transitional B Cells and TLR9 Responses Are Defective in Selective IgA Deficiency 
    Lemarquis, Andri Leo; Einarsdóttir, Helga K.; Kristjansdóttir, Rakel N.; Jonsdottir, Ingileif; Ludviksson, Bjorn (Frontiers Media SA, 2018-04-27)
    Selective IgA deficiency (IgAD) is the most common primary antibody deficiency in the western world with affected individuals suffering from an increased burden of autoimmunity, atopic diseases and infections. It has been shown that IgAD B cells can ...
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    Transplanting embryonic stem cells onto damaged human corneal endothelium 
    Hanson, Charles; Arnarsson, Arsaell; Harðarson, Þórir; Lindgård, Ann; Daneshvarnaeini, Mandana; Ellerström, Catarina; Bruun, Anita; Stenevi, Ulf (Baishideng Publishing Group Inc., 2017)
    AIM To investigate whether human embryonic stem cells (hESCs) could be made to attach, grow and differentiate on a human Descemet’s membrane (DM). METHODS Spontaneously differentiated hESCs were transferred onto a human corneal button with the ...