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Atriði 451-470 af 4526
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(MDPI AG, 2019-11-01)Mutations in BRCA1 result in predisposal to breast and ovarian cancers, but many variants exist with unknown clinical significance (VUS). One is BRCA1 c.4096+3A>G, which affects production of the full-length BRCA1 transcript, while augmenting transcripts ... -
(2019-12-11)Background: Breast Cancer 1 gene (BRCA1) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in BRCA1 are sensitive to cytotoxic drugs that cause DNA double strand breaks. However, ...
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(University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-11)Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is involved in maintaining genomic stability through its roles in DNA double strand break repair and protection of stalled replication forks. The BRCA2 gene ...
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(Informa UK Limited, 2018-12-07)This self-study, based on research, conducted over five years, focuses on my leadership role employing an inclusion model of education in a school in Iceland serving students from ages 6 to 16. In this article, we examine how Edda’s practice helped ...
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(Elsevier BV, 2020-04)The aim of this study was to examine when children learn to read and how learning to read depends on a foundation of alphabetic knowledge. 356 children aged 5–6 years completed assessments of letter-sound knowledge, i.e. the names and sounds of uppercase ...
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(Wiley, 2020-05-29)Aim: To explore the lived experience of individuals' in chronic pain of participating in a pain rehabilitation programme in Iceland. Design: Phenomenological research. Method: The Vancouver School of Doing Phenomenology. Eleven participants were ...
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(2022-01)BACKGROUND: Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant ...
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(2024-02-08)Although a number of high-risk breast cancer genes have been identified, including BRCA1 and BRCA2, the risk profile of many high-risk families cannot be explained using known breast cancer genes. Previously, we have shown strong indications of new ...
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(2020-11-24)Background: The natural history of breast cancer among BRCA2 carriers has not been clearly established. In a previous study from Iceland, positive ER status was a negative prognostic factor. We sought to identify factors that predicted survival after ...
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(2022-09-08)BACKGROUND: Twins and late preterm (LPT) infants are at an increased risk of being breastfed to a lesser extent than term singletons. This study aimed to describe the initiation and duration of any and exclusive breastfeeding at the breast for mothers ...
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(2022-01-12)Background: Breathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated potential inheritance of ...
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(University of Iceland, School of Engineering and Natural Sciences, Faculty of Earth Sciences, 2020-01)The Breiðdalur volcanic system, eastern Iceland, comprises of a ~600 km3 central volcano, a 30 - 40 km long dyke swarm and plateau basalts erupted from this dyke swarm. The entire volcanic system was active from 10.1 to 7.8 Ma, the central volcano was ...
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(2021-10)Introduction Infections due to COVID-19 can lead to life threatening pneumonia. Accompanying severe disease are more prominent pulmonary changes on Computed Tomography (CT) scan of the chest. The goal of this study was to describe pulmonary CT changes ...
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(2023)Markmið erindisins er að varpa ljósi á samhengi trúarbragða- og lífsskoðanafræðslu á Íslandi. Í fyrsta hluta þess verður fjallað um trúarbragðafræðslu í núgildandi aðalnámskrá og það sem vitað er um kennslu um trúarbrögð í grunnskólum. Kynntar verða ...
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(2016-01-04)Tilgangur: Sýklalyfjanotkun er ein helsta orsök sýklalyfjaónæmis hjá bakteríum og er mikilvægt að draga úr ónauðsynlegri notkun eins og hægt er. Sýklalyfjanotkun, og þá sérstaklega notkun breiðvirkra sýklalyfja, er mikil hér á landi. Markmið rannsóknarinnar ...
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(Guðfræðistofnun Háskóla Íslands, 2017)Meginviðfangsefni þessarar greinar er að rannsaka bréf Nýja testamentisins í ljósi bréfa-skrifta almennt í hinum grísk-rómverska heimi. Fyrst er gefið yfirlit yfir stöðu slíkra rann-sókna sem og yfir helstu einkenni grískra (og latneskra) bréfa í ...
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(University of Sydney, 2010-06)Introduction: CBTpsych.com is a fully functional intervention that aims at bridging the gap between Eliza (Weizenbaum, 1966) and modern internet treatments for anxiety disorders (Helgadottir, Menzies, Onslow, Packman & O‟Brien, 2009a). A Phase I trial ...
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(2021-06-17)While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling ...
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(2010-11-01)Ágrip Tilgangur: Að afla upplýsinga um brunaslys barna sem lögðust inn á Landspítala á níu ára tímabili, meta hvort efla þurfi forvarnir og endurskoða ákveðna þætti í meðferð. Aðferðir: Í þessari afturskyggnu lýsandi rannsókn var upplýsingum safnað úr ...
Atriði 451-470 af 4526