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Browsing by Subject "Mice, Inbred C57BL"

Browsing by Subject "Mice, Inbred C57BL"

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    BRN2 is a non-canonical melanoma tumor-suppressor 
    Hamm, Michael; Sohier, Pierre; Petit, Valérie; Raymond, Jérémy H.; Delmas, Véronique; Le Coz, Madeleine; Gesbert, Franck; Kenny, Colin; Aktary, Zackie; Pouteaux, Marie; Rambow, Florian; Sarasin, Alain; Charoenchon, Nisamanee; Bellacosa, Alfonso; Sanchez-del-Campo, Luis; Mosteo, Laura; Lauss, Martin; Meijer, Dies; Steingrímsson, Eiríkur; Jönsson, Göran B.; Cornell, Robert A.; Davidson, Irwin; Goding, Colin R.; Larue, Lionel (2021-06-17)
    While the major drivers of melanoma initiation, including activation of NRAS/BRAF and loss of PTEN or CDKN2A, have been identified, the role of key transcription factors that impose altered transcriptional states in response to deregulated signaling ...
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    Emu Oil and Saireito in combination reduce tumour development and clinical indicators of disease in a mouse model of colitis-associated colorectal cancer 
    Chartier, Lauren C.; Fujino, Junko; Howarth, Gordon S.; Freysdóttir, Jóna; Harðardóttir, Ingibjörg; Mashtoub, Suzanne (2021-06)
    BACKGROUND: Emu Oil (EO) previously demonstrated therapeutic potential in a mouse model of colitis-associated CRC (CA-CRC). Saireito, a traditional Japanese medicine, has not been investigated in CA-CRC. AIM: To determine whether EO and Saireito could ...
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    KMT2D regulates activation, localization, and integrin expression by T-cells 
    Potter, Sarah J.; Zhang, Li; Kotliar, Michael; Wu, Yuehong; Schafer, Caitlin; Stefan, Kurtis; Boukas, Leandros; Qu’d, Dima; Bodamer, Olaf; Simpson, Brittany N.; Barski, Artem; Lindsley, Andrew W.; Björnsson, Hans Tómas (2024-05-03)
    Individuals with Kabuki syndrome present with immunodeficiency; however, how pathogenic variants in the gene encoding the histone-modifying enzyme lysine methyltransferase 2D (KMT2D) lead to immune alterations remain poorly understood. Following up on ...
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    Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature 
    Daníelsson, Stefán Broddi; García-Llorca, Andrea; Reynisson, Hallur; Eysteinsson, Thor (2022-03-29)
    Purpose: Mice carrying pathogenic variants in the microphthalmia transcription factor (Mitf) gene show structural and functional changes in the retina and retinal pigment epithelium. The purpose of this study was to assess the vascular changes in Mitf ...