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Browsing by Author "Quirk, Sigríður Júlía"

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Comparison of Serotype Prevalence of Pneumococci Isolated from Middle Ear, Lower Respiratory Tract and Invasive Disease Prior to Vaccination in Iceland

Hjálmarsdóttir, Martha Ásdís; Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Erlendsdóttir, Helga; Haraldsson, Ásgeir; Kristinsson, Karl G. (Public Library of Science (PLoS), 2017-01-26)

Background Information on pneumococcal serotype distribution before vaccination is a prerequisite for evaluation of vaccine effect. The aim was to investigate the prevalence of pneumococcal serotypes isolated from middle ear (ME), lower respiratory ...
Effect of Vaccination on Pneumococci Isolated from the Nasopharynx of Healthy Children and the Middle Ear of Children with Otitis Media in Iceland

Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Erlendsdóttir, Helga; Hjálmarsdóttir, Martha Ásdís; van Tonder, Andries J.; Hrafnkelsson, Birgir; Sigurdsson, Samuel; Bentley, Stephen D.; Haraldsson, Ásgeir; Brueggemann, Angela B.; Kristinsson, Karl G. (American Society for Microbiology, 2018-09-26)

Vaccination with pneumococcal conjugate vaccines (PCVs) disrupts the pneumococcal population. Our aim was to determine the impact of the 10-valent PCV on the serotypes, genetic lineages, and antimicrobial susceptibility of pneumococci isolated from ...
Genomic Analyses of >3,100 Nasopharyngeal Pneumococci Revealed Significant Differences Between Pneumococci Recovered in Four Different Geographical Regions

van Tonder, Andries J.; Bray, James E.; Jolley, Keith A.; Jansen van Rensburg, Melissa; Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn; Maiden, Martin; Bentley, Stephen D.; Haraldsson, Ásgeir; Erlendsdóttir, Helga; Kristinsson, Karl G.; Brueggemann, Angela B. (Frontiers Media SA, 2019-02-25)

Understanding the structure of a bacterial population is essential in order to understand bacterial evolution. Estimating the core genome (those genes common to all, or nearly all, strains of a species) is a key component of such analyses. The size and ...
Nasopharyngeal competition dynamics are likely to be altered following vaccine introduction : bacteriocin prevalence and diversity among Icelandic and Kenyan pneumococci

Butler, Madeleine E B; Jansen van Rensburg, Melissa J; Karani, Angela; Mvera, Benedict; Akech, Donald; Akter, Asma; Forrest, Calum; van Tonder, Andries J; Quirk, Sigríður Júlía; Haraldsson, Gunnsteinn Ægir; Bentley, Stephen D; Erlendsdóttir, Helga; Haraldsson, Ásgeir; Kristinsson, Karl Gústaf; Scott, J Anthony G; Brueggemann, Angela B (2023-07)

Bacteriocins are antimicrobial peptides produced by bacteria to inhibit other bacteria in the surrounding environment. Streptococcus pneumoniae is a leading cause of disease worldwide and colonises the healthy human nasopharynx, where it competes for ...
Pneumococcal vaccination: Direct and herd effect on carriage of vaccine types and antibiotic resistance in Icelandic children

Sigurdsson, Samuel; Erlendsdóttir, Helga; Quirk, Sigríður Júlía; Kristjánsson, Júlíus; Hauksson, Kristján; Andrésdóttir, Birta Dögg Ingudóttir; Jónsson, Arnar Jan; Halldórsson, Kolbeinn Hans; Saemundsson, Arni; Ólason, Óli Hilmar; Hrafnkelsson, Birgir; Kristinsson, Karl G.; Haraldsson, Ásgeir (Elsevier BV, 2017-09)

Background Since the introduction of pneumococcal conjugate vaccines, vaccine type pneumococcal carriage and disease has decreased world-wide. The aim was to monitor changes in the nasopharyngeal carriage of pneumococci, the distribution of serotypes ...
Reduction of antimicrobial resistant pneumococci seven years after introduction of pneumococcal vaccine in Iceland

Hjálmarsdóttir, Martha Ásdís; Haraldsson, Gunnsteinn Ægir; Quirk, Sigríður Júlía; Haraldsson, Ásgeir; Erlendsdóttir, Helga; Kristinsson, Karl Gústaf (2020)

Background Penicillin non-susceptible (PNSP) and multi-resistant pneumococci have been prevalent in Iceland since early nineties, mainly causing problems in treatment of acute otitis media. The 10-valent protein conjugated pneumococcal vaccine (PHiD-CV) ...
Serotype and molecular epidemiology of pneumococci before and after pneumococcal vaccination

Quirk, Sigríður Júlía (University of Iceland, School of Health Sciences, Faculty of Medicine, 2019-04)

The pneumococcus is a major human pathogen that causes morbidity and mortality worldwide. Pneumococci are normally carried asymptomatically in the nasopharynx of healthy pre-school children. Pneumococcal infections can range from acute otitis media ...

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