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Browsing by Author "Saha, Subham"

Browsing by Author "Saha, Subham"

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    Advancement of covalent and noncovalent nitroxide spin-labeling of RNA 
    Saha, Subham (University of Iceland, School of Engineering and Natural Sciences, Faculty of Physical Sciences, 2017-06)
    Electron paramagnetic resonance (EPR) spectroscopy is routinely used to study the structure and dynamics of nucleic acids, to obtain information about their functions. A prerequisite for most EPR studies of nucleic acids is the incorporation of ...
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    Noncovalent spin-labeling of RNA: the aptamer approach 
    Saha, Subham; Hetzke, Thilo; Prisner, Thomas F.; Sigurdsson, Snorri (Royal Society of Chemistry (RSC), 2018)
    In the first example of site-directed spin-labeling of unmodified RNA, a pyrrolidine-nitroxide derivative of tetramethylrosamine (TMR) was shown to bind with high affinity to the malachite green (MG) aptamer, as determined by continuous-wave (CW) ...
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    Site-directed spin labeling of 2′-amino groups in RNA with isoindoline nitroxides that are resistant to reduction 
    Saha, Subham; Jagtap, Anil P.; Sigurdsson, Snorri (Royal Society of Chemistry (RSC), 2015)
    Two aromatic isothiocyanates, derived from isoindoline nitroxides, were synthesized and selectively reacted with 2′-amino groups in RNA. The spin labels displayed limited mobility in RNA, making them promising candidates for distance measurements by ...