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Dirk Smith, Hannes Helgason, Patrick Sulem, Unnur Steina Bjornsdottir, Ai Ching Lim, Gardar Sveinbjornsson, Haruki Hasegawa, Michael Brown, Randal R. Ketchem, Monica Gavala, Logan Garrett, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson, Olafur T. Magnusson, Gudmundur I. Eyjolfsson, Isleifur Olafsson, Pall Torfi Onundarson, Olof Sigurdardottir, David Gislason, Thorarinn Gislason, Bjorn Runar Ludviksson, Dora Ludviksdottir, H. Marike Boezen, Andrea Heinzmann, Marcus Krueger, Celeste Porsbjerg, Tarunveer S. Ahluwalia, Johannes Waage, Vibeke Backer, Klaus A. Deichmann, Gerard H. Koppelman, Klaus Bønnelykke, Hans Bisgaard, Gisli Masson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, James A. Johnston, Ingileif Jonsdottir, Kari Stefansson
A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
www.plosgenetics.org
www.plosgenetics.org
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Q
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(19)Tj
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(exon7:c.487-1G)Tj
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-0.005 Tc
(C,)Tj
/F17 1 Tf
8.1239 0 Td
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q
1 j
1 J
0 w
7.4999 0 0 6.6659 286.1291 484.3275 cm
BT
/F10 1 Tf
1 TL
-0.0067 Tc
0 0 Td
(adj)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 297.411 485.9716 cm
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/F10 1 Tf
1 TL
-0.005 Tc
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(=)Tj
0.7993 0 Td
(-0.21)Tj
2.2167 0 Td
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[()]TJ
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1 J
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7.4999 0 0 6.6659 349.5685 484.3275 cm
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1 TL
-0.0067 Tc
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(adj)Tj
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q
1 j
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1 TL
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(=)Tj
0.7993 0 Td
(2.5)Tj
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[()]TJ
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(10)Tj
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7.4999 0 0 6.6659 395.7732 490.4503 cm
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1 TL
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(16)Tj
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(\()Tj
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1 J
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7.4999 0 0 6.6659 355.9181 445.3228 cm
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1 TL
-0.0067 Tc
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(adj)Tj
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Q
q
1 j
1 J
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-0.005 Tc
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(=)Tj
0.7936 0 Td
(0.051)Tj
2.3414 0 Td
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[()]TJ
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1 J
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7.4999 0 0 6.6659 420.4913 445.3228 cm
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1 TL
-0.0067 Tc
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(adj)Tj
ET
Q
q
1 j
1 J
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1 TL
-0.005 Tc
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(=)Tj
0.7936 0 Td
(3.6)Tj
/F18 1 Tf
[()]TJ
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(10)Tj
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1 J
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7.4999 0 0 6.6659 466.6393 451.4456 cm
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1 TL
-0.0067 Tc
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(27)Tj
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Q
q
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1 J
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(and)Tj
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7.4999 0 0 6.6659 269.7448 438.4629 cm
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(2)Tj
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Q
q
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1 j
1 J
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7.4999 0 0 6.6659 347.1307 406.3181 cm
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1 TL
-0.0067 Tc
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(adj)Tj
ET
Q
q
1 j
1 J
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1 TL
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(=)Tj
0.7993 0 Td
(-0.023)Tj
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[()]TJ
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1 J
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7.4999 0 0 6.6659 415.3322 406.3181 cm
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1 TL
-0.0067 Tc
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(adj)Tj
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Q
q
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1 J
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(5.7)Tj
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[()]TJ
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(10)Tj
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7.4999 0 0 6.6659 461.537 412.4409 cm
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1 TL
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(7)Tj
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Q
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[()]TJ
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7.4999 0 0 6.6659 315.3826 399.4582 cm
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(6)Tj
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(20)Tj
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7.4999 0 0 6.6659 469.5307 386.4188 cm
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(2)Tj
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(0.02\))Tj
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7.4999 0 0 6.6659 228.5858 256.422 cm
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(2)Tj
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(S7)Tj
1.5137 0 Td
(Table)Tj
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(two)Tj
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